ID E7ENA5_HUMAN Unreviewed; 558 AA. AC E7ENA5; E7ETL4; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 02-JUN-2021, entry version 70. DE SubName: Full=Deleted in azoospermia protein 4 {ECO:0000313|Ensembl:ENSP00000371869}; GN Name=DAZ4 {ECO:0000313|Ensembl:ENSP00000371869}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371869, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000371869, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12815422; DOI=10.1038/nature01722; RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.; RT "The male-specific region of the human Y chromosome is a mosaic of discrete RT sequence classes."; RL Nature 423:825-837(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000371869} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC006338; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC006982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC010089; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; E7ENA5; -. DR ProteomicsDB; 17115; -. DR Antibodypedia; 5164; 138 antibodies. DR Ensembl; ENST00000382432; ENSP00000371869; ENSG00000205916. DR UCSC; uc065cvy.1; human. DR HGNC; HGNC:15966; DAZ4. DR OpenTargets; ENSG00000205916; -. DR VEuPathDB; HostDB:ENSG00000205916.11; -. DR GeneTree; ENSGT00530000063480; -. DR OMA; QPNPHTR; -. DR ChiTaRS; DAZ4; human. DR Proteomes; UP000005640; Chromosome Y. DR Bgee; ENSG00000205916; Expressed in stomach and 13 other tissues. DR ExpressionAtlas; E7ENA5; baseline. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. DR CDD; cd12672; RRM_DAZL; 1. DR Gene3D; 3.30.70.330; -; 1. DR InterPro; IPR037366; BOULE/DAZ. DR InterPro; IPR034778; DAZ1-4. DR InterPro; IPR043628; DAZ_dom. DR InterPro; IPR037551; DAZ_RRM_vert. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR PANTHER; PTHR11176; PTHR11176; 11. DR PANTHER; PTHR11176:SF8; PTHR11176:SF8; 11. DR Pfam; PF18872; Daz; 15. DR Pfam; PF00076; RRM_1; 1. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; SSF54928; 1. DR PROSITE; PS51890; DAZ; 15. DR PROSITE; PS50102; RRM; 1. PE 4: Predicted; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW Differentiation {ECO:0000256|ARBA:ARBA00022782}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00176}; Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}. FT DOMAIN 40..115 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 167..190 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 191..214 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 215..238 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 239..262 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 263..286 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 287..310 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 311..334 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 335..358 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 359..382 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 383..406 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 407..430 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 431..454 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 455..478 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 479..502 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT DOMAIN 503..526 FT /note="DAZ" FT /evidence="ECO:0000259|PROSITE:PS51890" FT REGION 1..27 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 558 AA; 63142 MW; 9F9037A212053E62 CRC64; MSAANPETPN STISREASTQ SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC ARHVQPRPLV VNPPPPPQFQ NVWRNPNTET YLQPQITPNP VTQHVQAYSA YPHSPGQVIT GCQLLVYNYQ EYPTYPDSAF QVTTGYQLPV YNYQPFPAYP RSPFQVTAGY QLPVYNYQAF PAYPNSPFQV ATGYQFPVYN YQPFPAYPSS PFQVTAGYQL PVYNYQAFPA YPNSPFQVAT GYQFPVYNYQ AFPAYPNSPV QVTTGYQLPV YNYQAFPAYP NSPFQVATGY QFPVYNYQAF PAYPNSPVQV TTGYQLPVYN YQAFPAYPSS PFQVTTGYQL PVYNYQAFPA YPSSPFQVTT GYQLPVYNYQ AFPAYPSSPF QVTTGYQLPV YNYQAFPAYP SSPFQVTTGY QLPVYNYQAF PAYPSSPFQV TTGYQLPVYN YQAFPAYPNS AVQVTTGYQF HVYNYQMPPQ CPVGEQRRNL WTEAYKWWYL VCLIQRRD //