ID   E7ENA5_HUMAN            Unreviewed;       558 AA.
AC   E7ENA5; E7ETL4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   12-AUG-2020, entry version 65.
DE   SubName: Full=Deleted in azoospermia protein 4 {ECO:0000313|Ensembl:ENSP00000371869};
GN   Name=DAZ4 {ECO:0000313|Ensembl:ENSP00000371869};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371869, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000371869, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000371869}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AC006338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; E7ENA5; -.
DR   PRIDE; E7ENA5; -.
DR   ProteomicsDB; 17115; -.
DR   Antibodypedia; 5164; 137 antibodies.
DR   Ensembl; ENST00000382432; ENSP00000371869; ENSG00000205916.
DR   UCSC; uc065cvy.1; human.
DR   EuPathDB; HostDB:ENSG00000205916.11; -.
DR   HGNC; HGNC:15966; DAZ4.
DR   OpenTargets; ENSG00000205916; -.
DR   GeneTree; ENSGT00530000063480; -.
DR   OMA; QPNPHTR; -.
DR   ChiTaRS; DAZ4; human.
DR   Proteomes; UP000005640; Chromosome Y.
DR   Bgee; ENSG00000205916; Expressed in stomach and 13 other tissues.
DR   ExpressionAtlas; E7ENA5; baseline.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR   CDD; cd12672; RRM_DAZL; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR037366; BOULE/DAZ.
DR   InterPro; IPR034778; DAZ1-4.
DR   InterPro; IPR037551; DAZ_RRM_vert.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR11176; PTHR11176; 11.
DR   PANTHER; PTHR11176:SF8; PTHR11176:SF8; 11.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW   Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT   DOMAIN          40..115
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  63142 MW;  9F9037A212053E62 CRC64;
     MSAANPETPN STISREASTQ SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF
     GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC
     ARHVQPRPLV VNPPPPPQFQ NVWRNPNTET YLQPQITPNP VTQHVQAYSA YPHSPGQVIT
     GCQLLVYNYQ EYPTYPDSAF QVTTGYQLPV YNYQPFPAYP RSPFQVTAGY QLPVYNYQAF
     PAYPNSPFQV ATGYQFPVYN YQPFPAYPSS PFQVTAGYQL PVYNYQAFPA YPNSPFQVAT
     GYQFPVYNYQ AFPAYPNSPV QVTTGYQLPV YNYQAFPAYP NSPFQVATGY QFPVYNYQAF
     PAYPNSPVQV TTGYQLPVYN YQAFPAYPSS PFQVTTGYQL PVYNYQAFPA YPSSPFQVTT
     GYQLPVYNYQ AFPAYPSSPF QVTTGYQLPV YNYQAFPAYP SSPFQVTTGY QLPVYNYQAF
     PAYPSSPFQV TTGYQLPVYN YQAFPAYPNS AVQVTTGYQF HVYNYQMPPQ CPVGEQRRNL
     WTEAYKWWYL VCLIQRRD
//