ID E5FGM8_MIOTA Unreviewed; 748 AA. AC E5FGM8; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 05-JUN-2019, entry version 28. DE SubName: Full=Nibrin {ECO:0000313|EMBL:ADQ01171.1}; DE Flags: Fragment; GN Name=NBN {ECO:0000313|EMBL:ADQ01171.1}; OS Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Miopithecus. OX NCBI_TaxID=36231 {ECO:0000313|EMBL:ADQ01171.1}; RN [1] {ECO:0000313|EMBL:ADQ01171.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=20975951; DOI=10.1371/journal.pgen.1001169; RA Demogines A., East A.M., Lee J.H., Grossman S.R., Sabeti P.C., RA Paull T.T., Sawyer S.L.; RT "Ancient and recent adaptive evolution of primate non-homologous end RT joining genes."; RL PLoS Genet. 6:E1001169-E1001169(2010). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM486835; ADQ01171.1; -; mRNA. DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro. DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro. DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint; IEA:InterPro. DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro. DR CDD; cd00027; BRCT; 1. DR CDD; cd00060; FHA; 1. DR Gene3D; 3.40.50.10190; -; 1. DR InterPro; IPR001357; BRCT_dom. DR InterPro; IPR036420; BRCT_dom_sf. DR InterPro; IPR013908; DNA-repair_Nbs1_C. DR InterPro; IPR000253; FHA_dom. DR InterPro; IPR040227; Nibrin-rel. DR InterPro; IPR032429; Nibrin_BRCT2. DR InterPro; IPR016592; Nibrin_met. DR InterPro; IPR008984; SMAD_FHA_dom_sf. DR PANTHER; PTHR12162; PTHR12162; 1. DR Pfam; PF00498; FHA; 1. DR Pfam; PF08599; Nbs1_C; 1. DR Pfam; PF16508; NIBRIN_BRCT_II; 1. DR PIRSF; PIRSF011869; Nibrin_animal; 1. DR SMART; SM00240; FHA; 1. DR SMART; SM01348; Nbs1_C; 1. DR SUPFAM; SSF49879; SSF49879; 1. DR SUPFAM; SSF52113; SSF52113; 1. DR PROSITE; PS50006; FHA_DOMAIN; 1. PE 2: Evidence at transcript level; FT DOMAIN 24 83 FHA. {ECO:0000259|PROSITE:PS50006}. FT REGION 326 345 Disordered. {ECO:0000256|MobiDB-lite: FT E5FGM8}. FT REGION 426 480 Disordered. {ECO:0000256|MobiDB-lite: FT E5FGM8}. FT REGION 504 552 Disordered. {ECO:0000256|MobiDB-lite: FT E5FGM8}. FT COMPBIAS 330 345 Polar. {ECO:0000256|MobiDB-lite:E5FGM8}. FT COMPBIAS 426 460 Polar. {ECO:0000256|MobiDB-lite:E5FGM8}. FT COMPBIAS 461 477 Polyampholyte. {ECO:0000256|MobiDB-lite: FT E5FGM8}. FT COMPBIAS 504 538 Polar. {ECO:0000256|MobiDB-lite:E5FGM8}. FT NON_TER 748 748 {ECO:0000313|EMBL:ADQ01171.1}. SQ SEQUENCE 748 AA; 84305 MW; 7E600DE2205ACF74 CRC64; MWKLLPVAGP AGGEPYRLLT GVEYVVGRKN CALLIENDQS ISRNHAVLTA NFSVTNLSQT DEIPVLTLKD NSKYGTFVNE EKMQNGFSRT LKSGDGITFG VFESKFRVEY EPLVACSSCL DVSGKTALNQ AILQLGGFTV NNWTEECTHL VMVSVKVTIK TICALICGRP IVKPEYFTEF LKAVQSKKQP PQIESFYPPL DEPSIGSKNV DLSGRQERKQ IFKGKTFIFL SAKQHKKLSS AVVFGGGEAR LITEENEEEH NLFLAPETCV VDTGITNSQT LIPDSQKKWI QSIMDMLQRQ GLRPIPEAEI GLAVIFMTTK NYCDPRGHPS TGLKTTTPGP SLSQGLSVDE KLMPSTPVNA TTCVADTESE QADTWDLSER PKEIKVSKME QKIRMLSQDT PTIKESCKTS SNNNSMVSNT LAKMRIPNYQ LSPTKLPSIN KSKDRASQQQ QTNSIRNYFQ PSTKKRERDE ENQEVSSCKS ARIEMSCSVL EQTQPATPSL WKNKEQHLSQ NEPVDTNSDD NLFTDTDLKS SVKNSASKSH ASEKLRSNKK REMDDVAIED EVLEQLFKDT KPELETVVKV QKQEEDVNIR KRPRMDIETN DTFSDEAVPE SSKISQENEI GKKRELKEGS LWSTKEEISD DSEMLPRKLL LTEFRSLVIE NSTSRNPSGI NDYGQLNNFK KFKKVTYPGA GKLPHIIGGS DLIPHHARKN TELEEWLRQE MEVQNQHAKE ESLADDLFRY NPYLKRRR //