ID E5FGM8_MIOTA Unreviewed; 748 AA. AC E5FGM8; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 11-DEC-2013, entry version 12. DE RecName: Full=Nibrin; DE Flags: Fragment; GN Name=NBN; OS Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Miopithecus. OX NCBI_TaxID=36231; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=20975951; DOI=10.1371/journal.pgen.1001169; RA Demogines A., East A.M., Lee J.H., Grossman S.R., Sabeti P.C., RA Paull T.T., Sawyer S.L.; RT "Ancient and recent adaptive evolution of primate non-homologous end RT joining genes."; RL PLoS Genet. 6:E1001169-E1001169(2010). CC -!- FUNCTION: Component of the MRE11-RAD50-NBN (MRN complex) which CC plays a critical role in the cellular response to DNA damage and CC the maintenance of chromosome integrity. The complex is involved CC in double-strand break (DSB) repair, DNA recombination, CC maintenance of telomere integrity, cell cycle checkpoint control CC and meiosis (By similarity). CC -!- SUBUNIT: Component of the MRN complex (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM486835; ADQ01171.1; -; mRNA. DR Gene3D; 2.60.200.20; -; 1. DR Gene3D; 3.40.50.10190; -; 1. DR InterPro; IPR001357; BRCT_dom. DR InterPro; IPR013908; DNA-repair_Nbs1_C. DR InterPro; IPR000253; FHA_dom. DR InterPro; IPR016592; Nibrin_met. DR InterPro; IPR008984; SMAD_FHA_domain. DR Pfam; PF00498; FHA; 1. DR Pfam; PF08599; Nbs1_C; 1. DR PIRSF; PIRSF011869; Nibrin_animal; 1. DR SMART; SM00292; BRCT; 1. DR SMART; SM00240; FHA; 1. DR SUPFAM; SSF49879; SSF49879; 1. DR SUPFAM; SSF52113; SSF52113; 1. DR PROSITE; PS50006; FHA_DOMAIN; 1. PE 2: Evidence at transcript level; KW Cell cycle; Chromosome; DNA damage; DNA repair; Meiosis; Nucleus; KW Telomere. FT NON_TER 748 748 SQ SEQUENCE 748 AA; 84305 MW; 7E600DE2205ACF74 CRC64; MWKLLPVAGP AGGEPYRLLT GVEYVVGRKN CALLIENDQS ISRNHAVLTA NFSVTNLSQT DEIPVLTLKD NSKYGTFVNE EKMQNGFSRT LKSGDGITFG VFESKFRVEY EPLVACSSCL DVSGKTALNQ AILQLGGFTV NNWTEECTHL VMVSVKVTIK TICALICGRP IVKPEYFTEF LKAVQSKKQP PQIESFYPPL DEPSIGSKNV DLSGRQERKQ IFKGKTFIFL SAKQHKKLSS AVVFGGGEAR LITEENEEEH NLFLAPETCV VDTGITNSQT LIPDSQKKWI QSIMDMLQRQ GLRPIPEAEI GLAVIFMTTK NYCDPRGHPS TGLKTTTPGP SLSQGLSVDE KLMPSTPVNA TTCVADTESE QADTWDLSER PKEIKVSKME QKIRMLSQDT PTIKESCKTS SNNNSMVSNT LAKMRIPNYQ LSPTKLPSIN KSKDRASQQQ QTNSIRNYFQ PSTKKRERDE ENQEVSSCKS ARIEMSCSVL EQTQPATPSL WKNKEQHLSQ NEPVDTNSDD NLFTDTDLKS SVKNSASKSH ASEKLRSNKK REMDDVAIED EVLEQLFKDT KPELETVVKV QKQEEDVNIR KRPRMDIETN DTFSDEAVPE SSKISQENEI GKKRELKEGS LWSTKEEISD DSEMLPRKLL LTEFRSLVIE NSTSRNPSGI NDYGQLNNFK KFKKVTYPGA GKLPHIIGGS DLIPHHARKN TELEEWLRQE MEVQNQHAKE ESLADDLFRY NPYLKRRR //