ID E4TLS4_MARTH Unreviewed; 177 AA. AC E4TLS4; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 27-MAR-2024, entry version 58. DE RecName: Full=Protoporphyrinogen IX oxidase {ECO:0000256|ARBA:ARBA00017504, ECO:0000256|HAMAP-Rule:MF_02239}; DE Short=PPO {ECO:0000256|HAMAP-Rule:MF_02239}; DE EC=1.3.99.- {ECO:0000256|HAMAP-Rule:MF_02239, ECO:0000256|PIRNR:PIRNR004638}; GN OrderedLocusNames=Ftrac_3379 {ECO:0000313|EMBL:ADR23353.1}; OS Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 OS / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus). OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Marivirgaceae; Marivirga. OX NCBI_TaxID=643867 {ECO:0000313|EMBL:ADR23353.1, ECO:0000313|Proteomes:UP000008720}; RN [1] {ECO:0000313|EMBL:ADR23353.1, ECO:0000313|Proteomes:UP000008720} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / RC H-43 {ECO:0000313|Proteomes:UP000008720}; RX PubMed=21677852; DOI=10.4056/sigs.1623941; RA Pagani I., Chertkov O., Lapidus A., Lucas S., Del Rio T.G., Tice H., RA Copeland A., Cheng J.F., Nolan M., Saunders E., Pitluck S., Held B., RA Goodwin L., Liolios K., Ovchinikova G., Ivanova N., Mavromatis K., Pati A., RA Chen A., Palaniappan K., Land M., Hauser L., Jeffries C.D., Detter J.C., RA Han C., Tapia R., Ngatchou-Djao O.D., Rohde M., Goker M., Spring S., RA Sikorski J., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., RA Klenk H.P., Kyrpides N.C.; RT "Complete genome sequence of Marivirga tractuosa type strain (H-43)."; RL Stand. Genomic Sci. 4:154-162(2011). CC -!- FUNCTION: Catalyzes the oxidation of protoporphyrinogen IX to CC protoporphyrin IX. {ECO:0000256|HAMAP-Rule:MF_02239, CC ECO:0000256|PIRNR:PIRNR004638}. CC -!- CATALYTIC ACTIVITY: CC Reaction=3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX; CC Xref=Rhea:RHEA:62000, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499, CC ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; CC Evidence={ECO:0000256|ARBA:ARBA00001093, ECO:0000256|HAMAP- CC Rule:MF_02239, ECO:0000256|PIRNR:PIRNR004638}; CC -!- COFACTOR: CC Name=heme b; Xref=ChEBI:CHEBI:60344; CC Evidence={ECO:0000256|HAMAP-Rule:MF_02239, CC ECO:0000256|PIRNR:PIRNR004638}; CC Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. CC {ECO:0000256|HAMAP-Rule:MF_02239, ECO:0000256|PIRNR:PIRNR004638}; CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX CC biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. CC {ECO:0000256|ARBA:ARBA00005073, ECO:0000256|HAMAP-Rule:MF_02239, CC ECO:0000256|PIRNR:PIRNR004638}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_02239}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|HAMAP-Rule:MF_02239}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_02239}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the HemJ family. {ECO:0000256|ARBA:ARBA00006501, CC ECO:0000256|HAMAP-Rule:MF_02239, ECO:0000256|PIRNR:PIRNR004638}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002349; ADR23353.1; -; Genomic_DNA. DR RefSeq; WP_013455495.1; NC_014759.1. DR AlphaFoldDB; E4TLS4; -. DR STRING; 643867.Ftrac_3379; -. DR KEGG; mtt:Ftrac_3379; -. DR eggNOG; COG1981; Bacteria. DR HOGENOM; CLU_125006_0_0_10; -. DR OrthoDB; 9800824at2; -. DR UniPathway; UPA00251; UER00324. DR Proteomes; UP000008720; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0070818; F:protoporphyrinogen oxidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule. DR HAMAP; MF_02239; HemJ; 1. DR InterPro; IPR005265; HemJ-like. DR PANTHER; PTHR40255:SF1; PROTOPORPHYRINOGEN IX OXIDASE; 1. DR PANTHER; PTHR40255; UPF0093 MEMBRANE PROTEIN SLR1790; 1. DR Pfam; PF03653; UPF0093; 1. DR PIRSF; PIRSF004638; UCP004638; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP- KW Rule:MF_02239}; KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|HAMAP-Rule:MF_02239}; KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_02239}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02239}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_02239}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP- KW Rule:MF_02239}; Reference proteome {ECO:0000313|Proteomes:UP000008720}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_02239}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_02239}. FT TRANSMEM 6..28 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" FT TRANSMEM 58..81 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" FT TRANSMEM 87..104 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" FT TRANSMEM 125..143 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" FT TRANSMEM 149..170 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" FT BINDING 9 FT /ligand="heme" FT /ligand_id="ChEBI:CHEBI:30413" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" FT BINDING 90 FT /ligand="heme" FT /ligand_id="ChEBI:CHEBI:30413" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02239" SQ SEQUENCE 177 AA; 21103 MW; 5ED30076D4C73070 CRC64; MYLYLKSLHI IFVVTWFAGL FYIVRLFIYQ TEALQKTEPE KSILHNQLSK MARLLWKVIT WPSAIITLIL ASSLLILQPF WLQQPFMHIK LTFVFFLYLY HFSCHYIYKK LQKGEIKYSS TQLRIWNEVA TLFLVAVVFL IVLKNELNWI WGTLGFISFG ILLMAAIKIY KALREKR //