ID   E3T1W4_PIG              Unreviewed;       459 AA.
AC   E3T1W4;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   07-OCT-2020, entry version 38.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297};
DE            EC=7.1.1.2 {ECO:0000256|RuleBase:RU003297};
GN   Name=ND4 {ECO:0000313|EMBL:ACZ44406.1};
OS   Sus scrofa taivanus.
OG   Mitochondrion {ECO:0000313|EMBL:ACZ44406.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=310261 {ECO:0000313|EMBL:ACZ44406.1};
RN   [1] {ECO:0000313|EMBL:ACZ44406.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ju Y.T., Wu C.Y., Jiang Y.N.;
RT   "Intra-population genetic structure of Lan-Yu pig (Sus scrofa) by analysis
RT   of mitochondrial genomic sequences.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|RuleBase:RU003297}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000766,
CC         ECO:0000256|RuleBase:RU003297};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       membrane {ECO:0000256|ARBA:ARBA00004225,
CC       ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU003297}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC       {ECO:0000256|ARBA:ARBA00009025, ECO:0000256|RuleBase:RU003297}.
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DR   EMBL; GU147934; ACZ44406.1; -; Genomic_DNA.
DR   RefSeq; YP_004021584.1; NC_014692.1.
DR   GeneID; 9978381; -.
DR   CTD; 4538; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR000260; NADH4_N.
DR   InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   PANTHER; PTHR43507; PTHR43507; 1.
DR   Pfam; PF01059; Oxidored_q5_N; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
DR   TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|RuleBase:RU003297};
KW   Membrane {ECO:0000256|RuleBase:RU003297};
KW   Mitochondrion {ECO:0000256|RuleBase:RU003297, ECO:0000313|EMBL:ACZ44406.1};
KW   NAD {ECO:0000256|RuleBase:RU003297};
KW   Respiratory chain {ECO:0000256|RuleBase:RU003297};
KW   Transmembrane {ECO:0000256|RuleBase:RU003297};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU003297};
KW   Transport {ECO:0000256|RuleBase:RU003297};
KW   Ubiquinone {ECO:0000256|RuleBase:RU003297}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        61..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        92..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        116..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        145..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        193..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        223..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        256..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        309..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        351..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        389..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003297"
FT   DOMAIN          1..109
FT                   /note="Oxidored_q5_N"
FT                   /evidence="ECO:0000259|Pfam:PF01059"
FT   DOMAIN          112..403
FT                   /note="Proton_antipo_M"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
SQ   SEQUENCE   459 AA;  51863 MW;  57ED6F89388E8935 CRC64;
     MLKIIIPTTM LLPMTWMSKH NMIWINATVH SLLISLISLS LLNQLGENSL NFSLTFFSDS
     LSAPLLVLTT WLLPLMLMAS QSHLSKETTT RKKLYITMLI LLQLFLIMTF TATELILFYI
     LFEATLVPTL IIITRWGNQT ERLNAGLYFL FYTLAGSLPL LVALVYIQNT TGSLNFLIIH
     YWSHPLSNSW SNIFMWLACI MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG
     YGMMRITTIL NPLTNYMAYP FLMLSMWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
     IMIQTPWSFM GATALMIAHG LTSSMLFCLA NTNYERVHSR TMILARGLQT LLPLMATWWL
     MASLTNLALP PSINLIGELF IITASFSWSN ITIILMGMNM MITALYSLYM LIITQRGKYT
     HHINNIKPSF TRENALMALH ILPLLLLTLN PKMILGPLY
//