ID E2RK30_CANLF Unreviewed; 4074 AA. AC E2RK30; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 28-FEB-2018, entry version 55. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000003171}; GN Name=PKHD1 {ECO:0000313|Ensembl:ENSCAFP00000003171}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000003171, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000003171, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000003171, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000003171} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000003171}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000003171}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAEX03008386; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAEX03008387; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAEX03008388; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005627522.1; XM_005627465.1. DR STRING; 9615.ENSCAFP00000003171; -. DR PaxDb; E2RK30; -. DR Ensembl; ENSCAFT00000003416; ENSCAFP00000003171; ENSCAFG00000002165. DR GeneID; 474934; -. DR CTD; 5314; -. DR eggNOG; ENOG410IEIF; Eukaryota. DR eggNOG; ENOG410XQ01; LUCA. DR GeneTree; ENSGT00780000121902; -. DR InParanoid; E2RK30; -. DR OMA; WVAGIKV; -. DR OrthoDB; EOG091G00JT; -. DR TreeFam; TF329582; -. DR Proteomes; UP000002254; Chromosome 12. DR Bgee; ENSCAFG00000002165; -. DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl. DR GO; GO:0005813; C:centrosome; IEA:Ensembl. DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl. DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl. DR GO; GO:0001822; P:kidney development; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl. DR GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl. DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl. DR Gene3D; 2.160.20.10; -; 1. DR Gene3D; 2.60.40.10; -; 5. DR InterPro; IPR019316; G8_domain. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR002909; IPT_dom. DR InterPro; IPR037524; PA14/GLEYA. DR InterPro; IPR011658; PA14_dom. DR InterPro; IPR006626; PbH1. DR InterPro; IPR012334; Pectin_lyas_fold. DR InterPro; IPR011050; Pectin_lyase_fold/virulence. DR InterPro; IPR028839; PKHD1. DR PANTHER; PTHR45107; PTHR45107; 1. DR Pfam; PF10162; G8; 2. DR Pfam; PF07691; PA14; 1. DR Pfam; PF01833; TIG; 8. DR SMART; SM01225; G8; 2. DR SMART; SM00429; IPT; 5. DR SMART; SM00710; PbH1; 9. DR SUPFAM; SSF51126; SSF51126; 2. DR SUPFAM; SSF81296; SSF81296; 6. DR PROSITE; PS51484; G8; 2. DR PROSITE; PS51820; PA14; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 4074 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003163621. FT TRANSMEM 3854 3877 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 323 483 PA14. {ECO:0000259|PROSITE:PS51820}. FT DOMAIN 1928 2049 G8. {ECO:0000259|PROSITE:PS51484}. FT DOMAIN 2743 2869 G8. {ECO:0000259|PROSITE:PS51484}. SQ SEQUENCE 4074 AA; 447576 MW; 173062C7FA7FC244 CRC64; MIVWLISLMS IEILLLAGPA LSFHIEPKEG SLAGGTWITV IFDGLELEQL YPTNGSQLEI HLVNVAVPAL PSIPCDVSPV FLDLPVVMCR TRSLLPEVHE GLYYLEAHAG GQVVGSPSPG LQDCCTFKFS REQTPIVYQV TPPSGVPGKM IHVYGWIITG RSETFDFDAE YIDSPLILEA QGDKWVTACS LINRQTGSCY PLQENHGLGT LQCRVEGNYI GSQNVSFSVF NKGKSMVHKN AWLVSAKLDL FLYQTYSEIL SVFPETGSLG GKTDIIITGD FFDNPALVTI AGVPCDIRHM SPRKIECTTR APGKRARLTA PQAGNRGLLF EVGEAVEGLD LTVATPGYRW QIVPNASSPF GFWFKEGQPF RARLSGFFVA PETNNYTFWI QADNQASLYF SQSEDPRMKV KVASIRVGTA DWFDAWEQDR NEGVWQRKTP KLELVGGTRY YLEAEHYGRT PSRGMRIGVQ IHNTWLNPDV VSTYLREKHQ IRVRAQRLPE IQMLTVSGRG SFFLTWDNVT SQPIPENATA HQIQTAIEEL LAVKCKLEPL SANILLWLGF EQGPEGSSFE GDLTSGTEPF CGRFSLHQPR RLVLTPPAAQ KDYWLDRYTH LCIAYKGRMK NILKVTVFFT TDFQNFIKKN ITCDWNLVGT RPNSWQFTCT DLWETCVHHS MYLQPPLVDS PVLVHRIDLF PLSQETSGFY VDEIIIADTN ITVSQADSET AHPGGNLVES LCVVGSPPVY NISFWLVGCG QELPLITASI VPTGGEARRS GLVQVTTQRI QKTSPPLGGY FHIQLPTSVI PDVPVHISAS HLRKLLQNNA DNFTSRYLNS SDLTVMEDLK SCYEHEWTLS WSSQVGDLPN FIRVSDANLT GVNPAATVRV VYDGGVFLGP VFGDMLVTAN QHTQVVVRVN DIPAHCSGSC SFQYLEGSTP QIHSAWYSLD GDISLLIYIF GINFSGDPQA LEIMVNKTNC KVIFSNQTNV ICQTDLLPVG MHRLFMVVRP FGRAINTSGE ALFLSVEPRL DAVEPSRAAE IGGLWATIQG SGLEDVSLVL FGSQSCAINI TTSNSRRIQC RVPPRGKDGP VVNLTVVSGD HSAVLPMAFT YVSSLNPVIT SLSRNRSNIA GGDTLFIRMA LLVNYTDLDV EVCIQNTLAP AHVQMPQGLE VVLPPLPAGL YSISVSINGI SIRSPGVDLH IQYITEVFSI EPCCGSLLGG TILSISGIGF IRDPTLVWVF VGNRSCDILN STETVIWCET PPAALLPDSN IPAIPVPMEI WAGNVSFARE SLLNLSFTFL YEAAMTPVVT AMRGEIINNS LRFYVEGNNL SNSVILLGVS HCDLETQTLR NNVSLSGCSF PLHSLEAGFY PLQVRQKQMG FANMSAVPQQ YVITPWIMAI SPTHGSACGG TVLTVRGLAL SSRKRSVQVD LLGPFTCVIL SLGHQTILCQ INKVNDSFPD VSFTLNVTVI VNGLPSECQG NCTLFLQEET TPIVDSLTTN ISGSLTMVLI RGRKLGITAV EPMVFVDDHL PCIVTFFNAS YVICWISDLT PGLHYVSVFH ARNGYACFGN VSRHFYILPQ VFHYFPKNFS IHGGSLLTVE GTALRGKNST LVYVGQQACL TVSISTELIQ CIVPAGNGSV GLVIEVDGLS YQMGVIGYSS AFTPRLLSIS QTDDVLTFAV AQVSGAENVD IFIGMSPCVG ISGNHTVLQC VVSSLPAGEY PVRGYDRMRG WASSVLVFTS TATISGVTEN FGCLGGRLVH VFGAGFSPGN VSAAVCGAPC QVLANATVSA FSCLVLPLNV SLAFLCGLKH SEESCEASSS TYVQCDLTVT VGTETLPQSW PYLYICEESP QCLFAPDHWT ESTFPWFSGL FISPKVERDE VLIYNSSCNI AMETEAKMEC ETPNQPITAK ITEIRKSRGQ STQGNFSLQF CLRWSRTHSW FPERVPQDGD NVTVENGQLL LLDTNTSILN LLHIKGGKLI FMDPGPIELR AHAILISDGG ELRIGSEDKP FQGKAEIKLY GSSHSTPFFP YGVKFLAVRN GTLSLHGLLP EVTFTHLQAA AYAGDTVLAL EDAVDWHPGD EAVIISRIGV GGAKPMEEIV IVEAVHNTDL YLRSPLRYSH NFTENWVAGV LHILKVTVVL LSRSITIQGN LTAERMKHLA SCQEASDSEG NLQDCLYSKS EKMLGSRDLG ARVIVQSFPE EPSRVQLRGV QFRDLGQAFR KHVSALTLVG AMRDSYVQGC TVWSSFNRGL SMSMTLGLKV DSNIFYNILG HALLVGTDMD IKYISWEAAP EKKPDWSEQG NIIRNNVIIS ISGTEGLSSP EMLTPSGIYI LNPTNVVEGN RVYVAGLGYF FHLVTSQTSQ APLLSFTQNI AHSCTRYGLF IYPQFQPPWD DGRGPTLFQN FTVWGSAGGA RISRSSNLHL KNFQVYSCRD FGIDILESDA NTSVTDSLLL GHFAHKGSLC MSAGIKTPKR WELIISNTTF VNFDLTDCVS IRTCSGCSRG QGGFTVKTNQ LKFINSPNLV AFPFPHAAIL EDLDGSLSGR NRSHILASME TLSASCLVNL SFSQIVPGSV CGEDVIFHHM SIGLANAPNV SYDLTITDSR NKTTTVNYVR DTLSNLYGWM ALLLDQETYS LQFETPWISR SLQYSATFGS FAPGNYLLLV HTVLWPYPDI LVRCGSQEGR SLPSLPLPGQ DQGCDWFFNT QLRQLIYLVS GEGQVQVTLQ VKEGVPPTIS ASTSAPESAL KWSLPEAWTG IEEGWGGHNH TIPGPGDDIL ILPNRTVLVD TNLPFLKGLY VMGTLEFPVD RSNVLSVACM VIAGGELKVG TLDNPLEKEQ KLLILLRASE GIFCDRLNGI HIDPGTIGVY GKVQLHGACP KKSWTRLAAD IASGNERIIV EDAVDWRPHD KIVLSSSSYE PHEAEILTVK EVQAHHVKIY ERLKYRHIGS VHVMEDGRCI RLAAEVGLLT RNIQIQPDIS CRARLLVGSF RNSSSKEFSG VLQLSNVEIQ NFGSPLYSSI EFTNASAGSW IISSSLHQSC SGGIRAAASH GIILNDNIVF GTVGHGIDLE GQNFSLSNNL VVLMTQSAWS TVWVAGIKAN QAKDINLYGN VVAGSERIGF HIQGHRCSSP EARWSDNVAH SSLHGLHLYK ENGLDNCTGI SGFLAFKNFD YGAMLHVENS VEIENITLVD NSIGLLATVY VSSVPKSHIE NVQIVLRNSV IIATSSSFDC IQDRVKPRSA NLTSSDRAPS NPRGGRVGIL WPIFTSEPNW WPQEPWHRVR NGHSTSGILK LQDVTFSNFV KSCYSDDLDI CILPNVENTG IMHPIMAEGT RMLKIKDKNK FYFPPLQARK GLGILVCPES DCENPRKYLF KDLDGRALGL PPPVSVFPKT EAEWTGSFFN TGTFREEQKC TYRALIQGYI CKQSDQAILI LDNADATWAM QKLYPVVSVT RGFVDTFSSV NADAPCSTSG SASTFYSILP TREITKICFV DQTPQVLRFF LLGNRSTSKL LLAVFYHELQ NPRVFIGESF IPPIMVQSTS SLLDESIGSN YFSILDNLLY VVLQGQEPIE IHSGVSIHLA LTVMFSVLEK GWEIIILERL TDFLQVSQDQ IRFIHEMPGN EATLKAIADN KAKRKRNCPT VTCASPYRVG QRRPLMTEMS SYRVPSPTIM ETASKVIVIE IGDLPTIRST RLISYLTSNK LQNLAHQIIT AQQTGVLENV LNMTIGALLV TQPKGVTDYG NASSFKTGNF IYIRPYALSV LVQPSDGEVG KELTVQPRLV FLDKQNQRIE SLGPPSEPWA ISVSLEGTSD PVLKGCTQAE SQDGYVSFSN LAVLISGSNW HFIFTVTSPP GANFTARSRS FTVLPAAPSE KSSIILAVSL CSVASWLALC CLVCCWFRKS KSRKIKSEDI SEFKTNDQKS HIHMSSKHPR SQETKKEDTM MGEDMKIKVI MDKVNQLPHQ SLNGVSRRKV SRRAVREEGS SREEDVVPAP RIISITSQGH TCVPGSPDQQ IYLQEAGNWK EAQEQLVSYQ LAGQDQRLLL CPDLRRERQQ LQGQSQLGQE GGSVGLSQEK KASGGATQAS CPHLVHPETI QEQL //