ID   E2R4W4_CANFA            Unreviewed;      1352 AA.
AC   E2R4W4;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-JUL-2011, entry version 9.
DE   SubName: Full=Uncharacterized protein;
GN   Name=ADCY9;
OS   Canis familiaris (Dog) (Canis lupus familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   IDENTIFICATION.
RC   STRAIN=Boxer;
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer;
RX   PubMed=16341006; DOI=10.1038/nature04338;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl
CC       cyclase family.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data.
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DR   RefSeq; XP_547151.2; XM_547151.2.
DR   ProteinModelPortal; E2R4W4; -.
DR   Ensembl; ENSCAFT00000030530; ENSCAFP00000028367; ENSCAFG00000019237.
DR   GeneID; 490031; -.
DR   KEGG; cfa:490031; -.
DR   CTD; 490031; -.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   Gene3D; G3DSA:3.30.70.1230; A/G_cyclase; 2.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   SMART; SM00044; CYCc; 2.
DR   SUPFAM; SSF55073; A/G_cyclase; 2.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   3: Inferred from homology;
KW   Complete proteome; Lyase; Nucleotide-binding.
SQ   SEQUENCE   1352 AA;  150620 MW;  4A35943BEC2B5C35 CRC64;
     MASPPHQQLL QHHSTEVSCD SSGDSNSVRV KINPRQLSSN SHPKHCKYSI SSSCSSSGDS
     GGVPRRAGAG GRLRRQKKLP QLFERASSRW WDPKFDSVNL EEACMERCFP QTQRRFRYAL
     FYVGFACLLW SIYFGVHMRS RLIVMVAPAL CFLVVCVGFF LFTFTKLYAR HYVWTSLVLT
     LLVFALTLAA QFQVLTPLSG RVDSSNHTLA AKRTDTCLSQ VGSFSMCIEV LFLLYTVMHL
     PLYLSLFLGV VYSVLFETFG YHFRDKDCFP PPGAGAPHWE LLSRALLHVC IHAIGIHLFI
     MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG DEESENSVKR
     HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI VGFTKMSANK SAHALVGLLN
     DLFGRFDRLC EETKCEKIST LGDCYYCVAG CPEPRADHAY CCIEMGLGMI RAIEQFCQEK
     KEMVNMRVGV HTGTVLCGIL GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD
     DRYEMEDGKV TERLGQSVVA DQLKGLKTYL IAGQRAKESH CSCTEALLSG FEVIDGSRVS
     SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAV QNGGQEEHKN
     STKAPGAPNS KTQNGLLSPP QEEKLTNSQT SLCEILQEKG RWAGVSLDQS ALLPLRFKNI
     REKTDAHFVD VIKEDSLMKD YFFKPPINEF SLNFLDQELE RSYRTSYQEE VIKNSPVKTF
     ASATFSSLLD VFLSTTVFLI LSITCFLKYG AAGTPPPPAA LAVFSAALLL EVLSLVVSVR
     MVFFLEDVMA CTKRLLEWIA GWLPRHFIGA ILVSLPALAV YSHVTSEFET NIHFTVFTGS
     AVLITVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYISLC PDSSIVISHL DAGQNFSSEG
     NPCNNSLPRD GRTASLIGQE VILVFFLLLL LVWFLNREFE VSYRLHYHGD VEADLHRTKI
     QSMRDQADWL LRNIIPYHVA EQLKVSQTYS KNHDSGGVIF ASIVNFSEFY EENYEGGKEC
     YRVLNELIGD FDELLSRPGY SSIEKIKTIG ATYMAASGLN GAQCQDGSHP QEHLQVLFEF
     AKEMMRVVDD FNSNMLWFNF KLRVGFNHGP LTAGVIGTTK LLYDIWGDTV NIASRMDSTG
     VECRIQVSEE SYRVLSKMGY DFDYRGTVNV KGKGQMKTYL YPKCMDSGAV PQHQLSISPD
     IRVQVDGSIG RSPTDEIANL VPSVQNVDKT SLGSENNVLA KDTHLSSKRP WKEPVKAEER
     CRFGKAIEKS DCEEAGMEEA SELTRLNISK SV
//