ID E2QJE9_ECOLX Unreviewed; 336 AA. AC E2QJE9; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 07-OCT-2020, entry version 86. DE RecName: Full=Dihydroorotate dehydrogenase (quinone) {ECO:0000256|HAMAP-Rule:MF_00225}; DE EC=1.3.5.2 {ECO:0000256|HAMAP-Rule:MF_00225}; DE AltName: Full=DHOdehase {ECO:0000256|HAMAP-Rule:MF_00225}; DE Short=DHOD {ECO:0000256|HAMAP-Rule:MF_00225}; DE Short=DHODase {ECO:0000256|HAMAP-Rule:MF_00225}; DE AltName: Full=Dihydroorotate oxidase {ECO:0000256|HAMAP-Rule:MF_00225}; GN Name=pyrD {ECO:0000256|HAMAP-Rule:MF_00225, GN ECO:0000313|EMBL:AUG92566.1}; GN ORFNames=AJ318_00520 {ECO:0000313|EMBL:PWR58818.1}, AM465_21305 GN {ECO:0000313|EMBL:AXZ04039.1}, APU18_21825 GN {ECO:0000313|EMBL:KSZ12912.1}, AWE53_021175 GN {ECO:0000313|EMBL:RRO77286.1}, AWF59_024750 GN {ECO:0000313|EMBL:RRO73229.1}, AWG78_003360 GN {ECO:0000313|EMBL:RRO48648.1}, AZZ83_000669 GN {ECO:0000313|EMBL:OUG34981.1}, B6V57_04750 GN {ECO:0000313|EMBL:AWG05874.1}, B9N33_06360 GN {ECO:0000313|EMBL:RBU23308.1}, BFD68_05045 GN {ECO:0000313|EMBL:ROL26534.1}, BON91_16080 GN {ECO:0000313|EMBL:TFA39578.1}, C4K41_10260 GN {ECO:0000313|EMBL:PPE30888.1}, CCZ14_06860 GN {ECO:0000313|EMBL:RAX67975.1}, CCZ17_01040 GN {ECO:0000313|EMBL:RAX86232.1}, CRJUMX01_770056 GN {ECO:0000313|EMBL:VEW08311.1}, CRT43_05545 GN {ECO:0000313|EMBL:AZH38259.1}, CT146_05735 GN {ECO:0000313|EMBL:PIM24931.1}, CUB99_02970 GN {ECO:0000313|EMBL:ATV46927.1}, D3C88_09200 GN {ECO:0000313|EMBL:RIB42216.1}, D3M98_01135 GN {ECO:0000313|EMBL:KAB1250772.1}, D4M76_17505 GN {ECO:0000313|EMBL:TXW73614.1}, D9E13_03020 GN {ECO:0000313|EMBL:EAC1988847.1}, D9E49_14840 GN {ECO:0000313|EMBL:MIB61652.1}, D9H10_09735 GN {ECO:0000313|EMBL:EAC1931886.1}, D9J46_01405 GN {ECO:0000313|EMBL:MGR71748.1}, DJ487_15925 GN {ECO:0000313|EMBL:TYD76171.1}, DL251_06535 GN {ECO:0000313|EMBL:EAA1121967.1}, DL979_17675 GN {ECO:0000313|EMBL:EAA1498699.1}, DMC44_11885 GN {ECO:0000313|EMBL:EAA1585502.1}, DMZ50_05315 GN {ECO:0000313|EMBL:EAA1819359.1}, DNR41_04215 GN {ECO:0000313|EMBL:RAH24927.1}, DS966_03160 GN {ECO:0000313|EMBL:RBX75537.1}, DU333_10630 GN {ECO:0000313|EMBL:RRK95457.1}, DW236_14680 GN {ECO:0000313|EMBL:RHG97426.1}, E0L04_00530 GN {ECO:0000313|EMBL:TZA23515.1}, EA159_05595 GN {ECO:0000313|EMBL:KAA1815952.1}, EA164_05465 GN {ECO:0000313|EMBL:KAA1824295.1}, EA167_14755 GN {ECO:0000313|EMBL:KAA1815415.1}, EA189_03815 GN {ECO:0000313|EMBL:KAA1887574.1}, EA191_14305 GN {ECO:0000313|EMBL:KAA1887052.1}, EA198_14640 GN {ECO:0000313|EMBL:KAA1923801.1}, EA200_03860 GN {ECO:0000313|EMBL:KAA1981218.1}, EA203_03890 GN {ECO:0000313|EMBL:KAA1952878.1}, EA222_12805 GN {ECO:0000313|EMBL:KAA2091501.1}, EA231_10580 GN {ECO:0000313|EMBL:KAA2097765.1}, EA232_17115 GN {ECO:0000313|EMBL:KAA2103205.1}, EA235_02315 GN {ECO:0000313|EMBL:KAA2116229.1}, EA239_01140 GN {ECO:0000313|EMBL:KAA2149004.1}, EA242_01850 GN {ECO:0000313|EMBL:KAA2162363.1}, EA245_01855 GN {ECO:0000313|EMBL:KAA2178577.1}, EA247_02150 GN {ECO:0000313|EMBL:KAA1873646.1}, EA250_01120 GN {ECO:0000313|EMBL:KAA1841174.1}, EA410_13715 GN {ECO:0000313|EMBL:KAA1831513.1}, EA429_10265 GN {ECO:0000313|EMBL:KAA2188384.1}, EA434_05945 GN {ECO:0000313|EMBL:KAA2164745.1}, EA435_18840 GN {ECO:0000313|EMBL:KAA2192526.1}, EA834_16135 GN {ECO:0000313|EMBL:KAA2308278.1}, ECTO124_03142 GN {ECO:0000313|EMBL:SYX31712.1}, EGT48_24610 GN {ECO:0000313|EMBL:RSB71353.1}, ELT22_06930 GN {ECO:0000313|EMBL:TFR21606.1}, ELT23_02645 GN {ECO:0000313|EMBL:TFR22232.1}, ELT48_03390 GN {ECO:0000313|EMBL:TFS85004.1}, ELU82_00370 GN {ECO:0000313|EMBL:TFQ77860.1}, ELU96_18085 GN {ECO:0000313|EMBL:TFQ60441.1}, ELV00_01895 GN {ECO:0000313|EMBL:TFP50153.1}, ELV05_00385 GN {ECO:0000313|EMBL:TFP26379.1}, ELV13_01285 GN {ECO:0000313|EMBL:TFP11583.1}, ELV22_05820 GN {ECO:0000313|EMBL:TFO95052.1}, ELV24_01600 GN {ECO:0000313|EMBL:TFP00455.1}, ELX56_02995 GN {ECO:0000313|EMBL:TFO56688.1}, ELX70_08760 GN {ECO:0000313|EMBL:TFN82107.1}, ELX79_00160 GN {ECO:0000313|EMBL:TFN60211.1}, ELX83_05930 GN {ECO:0000313|EMBL:TFM76837.1}, ELY23_13600 GN {ECO:0000313|EMBL:TFL78236.1}, ELY24_01085 GN {ECO:0000313|EMBL:TFM28220.1}, ELY50_07580 GN {ECO:0000313|EMBL:TFL68617.1}, EPS76_04720 GN {ECO:0000313|EMBL:RXD17520.1}, EPS94_06220 GN {ECO:0000313|EMBL:RXB48943.1}, EQO00_16375 GN {ECO:0000313|EMBL:QBR58174.1}, ERS085406_01231 GN {ECO:0000313|EMBL:CTU42337.1}, EWK56_13285 GN {ECO:0000313|EMBL:RYL81832.1}, ExPECSC065_00585 GN {ECO:0000313|EMBL:GCR90881.1}, EYX99_08240 GN {ECO:0000313|EMBL:TIJ92825.1}, FNJ67_16855 GN {ECO:0000313|EMBL:QDN42117.1}, FPI65_05630 GN {ECO:0000313|EMBL:NDR90784.1}, FQU83_17440 GN {ECO:0000313|EMBL:QDX37397.1}, G3565_07115 GN {ECO:0000313|EMBL:NES48343.1}, GFU40_11570 GN {ECO:0000313|EMBL:MQQ76651.1}, GFU45_06290 GN {ECO:0000313|EMBL:MQR80925.1}, GFU47_06260 GN {ECO:0000313|EMBL:MQR33521.1}, GJ638_03280 GN {ECO:0000313|EMBL:MUU91410.1}, GKE92_04945 GN {ECO:0000313|EMBL:MSI93686.1}, GKE98_17895 GN {ECO:0000313|EMBL:MSI12658.1}, GQE47_00420 GN {ECO:0000313|EMBL:MWE06174.1}, GQE58_01845 GN {ECO:0000313|EMBL:MWD96924.1}, GQS26_02200 GN {ECO:0000313|EMBL:MWG09083.1}, GUI33_15315 GN {ECO:0000313|EMBL:MZZ83056.1}, HmCms169_02059 GN {ECO:0000313|EMBL:GCS72510.1}, HmCmsJML146_02861 GN {ECO:0000313|EMBL:GDA13922.1}, MS8345_00942 GN {ECO:0000313|EMBL:AUG92566.1}, NCTC10089_03293 GN {ECO:0000313|EMBL:VTR21303.1}, NCTC10767_04843 GN {ECO:0000313|EMBL:STC88669.1}, NCTC8621_03376 GN {ECO:0000313|EMBL:STH83353.1}, NCTC8959_00544 GN {ECO:0000313|EMBL:STE09924.1}, NCTC9001_01181 GN {ECO:0000313|EMBL:VFS13731.1}, NCTC9434_03453 GN {ECO:0000313|EMBL:STN18645.1}, SY51_05320 GN {ECO:0000313|EMBL:AJO82901.1}, U12A_01026 GN {ECO:0000313|EMBL:QAY43816.1}, U14A_01027 GN {ECO:0000313|EMBL:QAZ90238.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:AJO82901.1, ECO:0000313|Proteomes:UP000032290}; RN [1] {ECO:0000313|EMBL:AJO82901.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MNCRE44 {ECO:0000313|EMBL:AJO82901.1}; RX PubMed=26438492; DOI=10.1128/AAC.01291-15; RA Hargreaves M.L., Shaw K.M., Dobbins G., Snippes Vagnone P.M., Harper J.E., RA Boxrud D., Lynfield R., Aziz M., Price L.B., Silverstein K.A., RA Danzeisen J.L., Youmans B., Case K., Sreevatsan S., Johnson T.J.; RT "Clonal Dissemination of Enterobacter cloacae Harboring blaKPC-3 in the RT Upper Midwestern United States."; RL Antimicrob. Agents Chemother. 59:7723-7734(2015). RN [2] {ECO:0000313|EMBL:AJO82901.1, ECO:0000313|Proteomes:UP000032290} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MNCRE44 {ECO:0000313|EMBL:AJO82901.1, RC ECO:0000313|Proteomes:UP000032290}; RX PubMed=25858844; RA Johnson T.J., Hargreaves M., Shaw K., Snippes P., Lynfield R., Aziz M., RA Price L.B.; RT "Complete Genome Sequence of a Carbapenem-Resistant Extraintestinal RT Pathogenic Escherichia coli Strain Belonging to the Sequence Type 131 H30R RT Subclade."; RL Genome Announc. 3:0-0(2015). RN [3] {ECO:0000313|EMBL:CTU42337.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=702898_aEPEC {ECO:0000313|EMBL:CTU42337.1}; RA Rikkerink E.H.A., Fineran P.C.; RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal RT Agent of Kiwifruit Canker Disease."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000043018} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=702898_aEPEC {ECO:0000313|Proteomes:UP000043018}, NCTC10089 RC {ECO:0000313|EMBL:VTR21303.1, ECO:0000313|Proteomes:UP000406392}, and RC NCTC9001 {ECO:0000313|EMBL:VFS13731.1, RC ECO:0000313|Proteomes:UP000372890}; RG Pathogen Informatics; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:KSZ12912.1, ECO:0000313|Proteomes:UP000053450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=50870281 {ECO:0000313|EMBL:KSZ12912.1, RC ECO:0000313|Proteomes:UP000053450}; RA Gilbert D.G.; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|Proteomes:UP000059691, ECO:0000313|Proteomes:UP000065249} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GN02175 {ECO:0000313|Proteomes:UP000065249}, and GN02766 RC {ECO:0000313|Proteomes:UP000059691}; RA Adams M., Sutton G., Nelson K., Thaden J., Fowler V., Mccorrison J., RA Sanka R., Brinkac L., Nierman W.; RT "WGS of SAMN04407783."; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:RRO73229.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GN02175 {ECO:0000313|EMBL:RRO77286.1}, GN02766 RC {ECO:0000313|EMBL:RRO73229.1}, and GN05696 RC {ECO:0000313|EMBL:RRO48648.1}; RA Adams M., Sutton G., Nelson K., Thaden J., Fowler V., Mccorrison J., RA Sanka R., Brinkac L., Nierman W.; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000076551} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GN05696 {ECO:0000313|Proteomes:UP000076551}; RA Adams M., Sutton G., Nelson K., Thaden J., Fowler V., Mccorrison J., RA Sanka R., Brinkac L., Nierman W.; RT "WGS of SAMN04578345."; RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:ROL26534.1, ECO:0000313|Proteomes:UP000285976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HE-MDREc68 {ECO:0000313|EMBL:ROL26534.1, RC ECO:0000313|Proteomes:UP000285976}; RX PubMed=28584139; RA Kanamori H., Parobek C.M., Juliano J.J., Johnson J.R., Johnston B.D., RA Johnson T.J., Weber D.J., Rutala W.A., Anderson D.J.; RT "Genomic Analysis of Multidrug-Resistant Escherichia coli from North RT Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131- RT H30Rx and ST131-H30R1 Strains."; RL Antimicrob. Agents Chemother. 61:e00912-17(2017). RN [10] {ECO:0000313|EMBL:RAX67975.1, ECO:0000313|Proteomes:UP000250807, ECO:0000313|Proteomes:UP000251114} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1408220042 {ECO:0000313|EMBL:RAX86232.1, RC ECO:0000313|Proteomes:UP000251114}, and 1608190062 RC {ECO:0000313|EMBL:RAX67975.1, ECO:0000313|Proteomes:UP000250807}; RX PubMed=29225701; DOI=10.1186/s13099-017-0220-y; RA Feng Y., Mannion A., Madden C.M., Swennes A.G., Townes C., Byrd C., RA Marini R.P., Fox J.G.; RT "Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic RT necrotizing factor (CNF) colonize laboratory macaques."; RL Gut Pathog 9:71-71(2017). RN [11] {ECO:0000313|EMBL:TFA39578.1, ECO:0000313|Proteomes:UP000297637} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HvH-Ec81 {ECO:0000313|EMBL:TFA39578.1, RC ECO:0000313|Proteomes:UP000297637}; RA Gumpert H., Hartung Hansen K., Bortolaia V., Jana B., Westh H., Agerso Y., RA Guardabassi L.; RT "Whole genome sequencing of CTX-M-14-producing Escherichia coli of animal RT and human origin: insights into dissemination of blaCTX-M-14."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AWG05874.1, ECO:0000313|Proteomes:UP000324147} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ZJ3920 {ECO:0000313|EMBL:AWG05874.1, RC ECO:0000313|Proteomes:UP000324147}; RA Shen Z., Wu Z., Wang Y., Shen Y.; RT "Whole genome analysis revealed super genetic diversity of mcr-1 positive RT E. coli strains from one hospital."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:OUG34981.1, ECO:0000313|Proteomes:UP000194954} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCI121 {ECO:0000313|EMBL:OUG34981.1}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genomic Center for Infectious Diseases; RA Earl A., Cerqueira G., Kirby J., Ferraro M., Onderdonk A., Delaney M., RA Kim D., Gussin G., Young S., Abouelleil A., Cao P., Chapman S., Cusick C., RA Shea T., Neafsey D., Nusbaum C., Birren B.; RT "The Genome Sequence of Escherichia coli UCI121."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:RBU23308.1, ECO:0000313|Proteomes:UP000252181} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CVAST1183 {ECO:0000313|EMBL:RBU23308.1, RC ECO:0000313|Proteomes:UP000252181}; RA Johnson T.J., Johnson J.R.; RT "Within host evolution of Escherichia coli isolates within the fecal flora RT of colonized patients."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AZH38259.1, ECO:0000313|Proteomes:UP000280867} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4/4 {ECO:0000313|EMBL:AZH38259.1, RC ECO:0000313|Proteomes:UP000280867}; RA Sandegren L.; RT "Dynamics of resistance plasmids in extended spectrum beta-lactamase- RT producing Enterobacteriaceae in the gut microflora of patients during 1 RT year post UTI."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:PIM24931.1, ECO:0000313|Proteomes:UP000229602} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ABU 91 {ECO:0000313|EMBL:PIM24931.1, RC ECO:0000313|Proteomes:UP000229602}; RA Stork C., Kovacs B., Trost E., Kovacs T., Schneider G., Rozsai B., RA Kerenyi M., Emody L., Dobrindt U.; RT "Whole-genome draft sequences of nine asymptomatic Escherichia coli RT bacteriuria isolates from diabetic patients."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:ATV46927.1, ECO:0000313|Proteomes:UP000231009} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LS4 {ECO:0000313|EMBL:ATV46927.1, RC ECO:0000313|Proteomes:UP000231009}; RA Tan c.; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:AUG92566.1, ECO:0000313|Proteomes:UP000233584} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MS8345 {ECO:0000313|EMBL:AUG92566.1, RC ECO:0000313|Proteomes:UP000233584}; RA Forde B.M., Zowawi H.M., Harris P., Roberts L., Ibrahim E., Shaikh N., RA Deshmukh A., Al Maslamani M., Cottrell K., Trembizki E., Sundac L., Yu H., RA Li J., Schembri M.A., Whiley D., Paterson D.L., Beatson S.A.; RT "Mcr-1 mediated colistin resistant Escherichia coli ST95 from Qatar."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:RIB42216.1, ECO:0000313|Proteomes:UP000284508} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S308 {ECO:0000313|EMBL:RIB42216.1, RC ECO:0000313|Proteomes:UP000284508}; RA Geslain G., Birgy A., Adiba S., Magnan M., Courroux C., Levy C., Cohen R., RA Bidet P., Bonacorsi S.; RT "Genome sequencing of strains of the most prevalent clonal group of RT O1:K1:H7 Escherichia coli that causes neonatal meningitis in France."; RL BMC Microbiol. 0:0-0(2018). RN [20] {ECO:0000313|EMBL:PPE30888.1, ECO:0000313|Proteomes:UP000238807} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DP254 {ECO:0000313|EMBL:PPE30888.1, RC ECO:0000313|Proteomes:UP000238807}; RA Xu A., Johnson J.R., Sheen S., Sommers C.H.; RT "Draft Genomic Sequencing Of Potential Extraintestinal Pathogenic RT Escherichia coli DP254 Isolated From Retail Chicken Meat."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|Proteomes:UP000298985, ECO:0000313|Proteomes:UP000303541, ECO:0000313|Proteomes:UP000304638} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ECSC065 {ECO:0000313|EMBL:GCR90881.1, RC ECO:0000313|Proteomes:UP000298985}, HUST169 RC {ECO:0000313|EMBL:GCS72510.1, ECO:0000313|Proteomes:UP000303541}, and RC JML146 {ECO:0000313|EMBL:GDA13922.1, RC ECO:0000313|Proteomes:UP000304638}; RA Arimizu Y., Ogura Y.; RT "Large scale genomics of bovine and human commensal E. coli to reveal the RT emerging process of EHEC."; RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:PWR58818.1, ECO:0000313|Proteomes:UP000245692} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BCW_5717 {ECO:0000313|EMBL:PWR58818.1, RC ECO:0000313|Proteomes:UP000245692}; RA Kong N., Foutouhi A., Huang B.C., Arabyan N., Thao K., Ng W., Storey D., RA Cai L., Lee E., Jeannotte R., Kelly L., Weimer B.C.; RT "A Next Generation Sequencing Library Workflow for Foodborne Pathogens with RT Quality Control Parameters for Quantification and Shearing conditions using RT the Agilent 2200 TapeStation System."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:TYD76171.1, ECO:0000313|Proteomes:UP000323638} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P099B P {ECO:0000313|EMBL:TYD76171.1, RC ECO:0000313|Proteomes:UP000323638}; RA Chen Y., Brook T.C., O'Neill I., Soe C.Z., Hall L.J., Hoyles L.; RT "Isolation and genomic analyses of lactose-positive bacteria from faecal RT samples of preterm neonates."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:RAH24927.1, ECO:0000313|Proteomes:UP000249503} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CG1MAC {ECO:0000313|EMBL:RAH24927.1, RC ECO:0000313|Proteomes:UP000249503}; RA Fang X.; RT "Metagenomics-based, strain-level analysis of E. coli from a time-series of RT microbiome samples from a Crohns disease patient."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|Proteomes:UP000254647, ECO:0000313|Proteomes:UP000254730, ECO:0000313|Proteomes:UP000255093} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC10767 {ECO:0000313|EMBL:STC88669.1, RC ECO:0000313|Proteomes:UP000254647}, NCTC8621 RC {ECO:0000313|EMBL:STH83353.1, ECO:0000313|Proteomes:UP000255093}, RC NCTC8959 {ECO:0000313|EMBL:STE09924.1, RC ECO:0000313|Proteomes:UP000255118}, and NCTC9434 RC {ECO:0000313|EMBL:STN18645.1, ECO:0000313|Proteomes:UP000254730}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:EAA1819359.1, ECO:0000313|Proteomes:UP000360051} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=318425 {ECO:0000313|EMBL:EAA1819359.1, RC ECO:0000313|Proteomes:UP000360051}, 417247 RC {ECO:0000313|EMBL:EAA1498699.1, ECO:0000313|Proteomes:UP000329907}, RC 451915 {ECO:0000313|EMBL:EAA1121967.1, RC ECO:0000313|Proteomes:UP000336005}, and 507309 RC {ECO:0000313|EMBL:EAA1585502.1, ECO:0000313|Proteomes:UP000403478}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:RBX75537.1, ECO:0000313|Proteomes:UP000253299} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AVC251 {ECO:0000313|EMBL:RBX75537.1, RC ECO:0000313|Proteomes:UP000253299}; RA Cummins M.L., Reid C.J., Roy Chowdhury P., Bushell R., Esbert N., RA Tivendale K.A., Noormohammadi A.H., Islam S., Marenda M.S., Browning G.F., RA Markham P.F., Djordjevic S.P.; RT "Whole Genome Sequence Analysis of Avian Pathogenic E. coli - An Australian RT Perspective."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:RHG97426.1, ECO:0000313|Proteomes:UP000284643} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AM20-38 {ECO:0000313|EMBL:RHG97426.1, RC ECO:0000313|Proteomes:UP000284643}; RA Zou Y., Xue W., Luo G.; RT "A genome reference for cultivated species of the human gut microbiota."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:SYX31712.1, ECO:0000313|Proteomes:UP000294333} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Escherichia coli str. TO124 {ECO:0000313|EMBL:SYX31712.1}; RA Gonzaga-Molto A.; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:KAB1250772.1, ECO:0000313|Proteomes:UP000429274} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=367 ECC {ECO:0000313|EMBL:KAB1250772.1, RC ECO:0000313|Proteomes:UP000429274}; RA Cho S., Sharma P., Gupta S.K., Mcmillan E.A., Jackson C.R., Frye J.G.; RT "Genetic Characterization of Antimicrobial Resistant Escherichia coli and RT Identification of a CTX-M-15 Encoding ST131 Isolate from a Mixed-Use RT Watershed in Georgia, USA."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:TXW73614.1, ECO:0000313|Proteomes:UP000477630} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=N039.H-6 {ECO:0000313|EMBL:TXW73614.1, RC ECO:0000313|Proteomes:UP000477630}; RA Gasparrini A.J.; RT "Persistent metagenomic signatures of early life antibiotic treatment in RT the infant gut microbiota and resistome."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [32] {ECO:0000313|EMBL:AXZ04039.1, ECO:0000313|Proteomes:UP000264112} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AR_0086 {ECO:0000313|EMBL:AXZ04039.1, RC ECO:0000313|Proteomes:UP000264112}; RA Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.; RT "Whole genome sequencing of Escherichia coli AR_0086."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [33] {ECO:0000313|Proteomes:UP000323211} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EC70_ST131H {ECO:0000313|Proteomes:UP000323211}; RA Hastak P.; RT "Genomic surveillance of multi-drug resistant E. coli causing blood-stream RT infections."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [34] {ECO:0000313|Proteomes:UP000344880, ECO:0000313|Proteomes:UP000353002, ECO:0000313|Proteomes:UP000396867} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EC11_ST95C {ECO:0000313|EMBL:KAA2188384.1, RC ECO:0000313|Proteomes:UP000408257}, EC120_ST131C RC {ECO:0000313|EMBL:KAA2192526.1, ECO:0000313|Proteomes:UP000400300}, RC EC128_ST8197H {ECO:0000313|EMBL:KAA2164745.1, RC ECO:0000313|Proteomes:UP000353002}, EC147_ST73C RC {ECO:0000313|EMBL:KAA2178577.1, ECO:0000313|Proteomes:UP000434336}, RC EC152_ST95C {ECO:0000313|EMBL:KAA2149004.1, RC ECO:0000313|Proteomes:UP000478303}, EC15_ST5242C RC {ECO:0000313|EMBL:KAA2162363.1, ECO:0000313|Proteomes:UP000432531}, RC EC169_ST73C {ECO:0000313|EMBL:KAA2116229.1, RC ECO:0000313|Proteomes:UP000448800}, EC179_ST131C RC {ECO:0000313|EMBL:KAA2103205.1, ECO:0000313|Proteomes:UP000405220}, RC EC19_ST372C {ECO:0000313|EMBL:KAA2091501.1, RC ECO:0000313|Proteomes:UP000434743}, EC282_ST73C RC {ECO:0000313|EMBL:KAA1981218.1, ECO:0000313|Proteomes:UP000430254}, RC EC297_ST131C {ECO:0000313|EMBL:KAA1952878.1, RC ECO:0000313|Proteomes:UP000396867}, EC2_ST95C RC {ECO:0000313|EMBL:KAA2097765.1, ECO:0000313|Proteomes:UP000430570}, RC EC330_ST681C {ECO:0000313|EMBL:KAA1923801.1, RC ECO:0000313|Proteomes:UP000433772}, EC372_ST95C RC {ECO:0000313|EMBL:KAA1887574.1, ECO:0000313|Proteomes:UP000433794}, RC EC393_ST131C {ECO:0000313|EMBL:KAA1873646.1, RC ECO:0000313|Proteomes:UP000441039}, EC44_ST131H RC {ECO:0000313|EMBL:KAA1887052.1, ECO:0000313|Proteomes:UP000431974}, RC EC68_ST95C {ECO:0000313|EMBL:KAA1841174.1, RC ECO:0000313|Proteomes:UP000408798}, EC70_ST131H RC {ECO:0000313|EMBL:KAA2308278.1}, EC7_ST144C RC {ECO:0000313|EMBL:KAA1831513.1, ECO:0000313|Proteomes:UP000421033}, RC EC84_ST131H {ECO:0000313|EMBL:KAA1824295.1, RC ECO:0000313|Proteomes:UP000448912}, EC87_ST131C RC {ECO:0000313|EMBL:KAA1815952.1, ECO:0000313|Proteomes:UP000344880}, RC and EC8_ST131C {ECO:0000313|EMBL:KAA1815415.1, RC ECO:0000313|Proteomes:UP000399267}; RA Hastak P., Myers G., Djordjevic S., Chowdhury P.R.; RT "Genomic surveillance of multi-drug resistant E. coli causing blood-stream RT infections."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [35] {ECO:0000313|Proteomes:UP000271175, ECO:0000313|Proteomes:UP000280919, ECO:0000313|Proteomes:UP000373733} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CVM N17EC0202 {ECO:0000313|EMBL:EAC1988847.1, RC ECO:0000313|Proteomes:UP000413318}, CVM N17EC0276 RC {ECO:0000313|EMBL:MIB61652.1, ECO:0000313|Proteomes:UP000271175}, CVM RC N17EC0820 {ECO:0000313|EMBL:EAC1931886.1, RC ECO:0000313|Proteomes:UP000373733}, and CVM N17EC1300 RC {ECO:0000313|EMBL:MGR71748.1, ECO:0000313|Proteomes:UP000280919}; RG NARMS: The National Antimicrobial Resistance Monitoring System; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [36] {ECO:0000313|EMBL:RRK95457.1, ECO:0000313|Proteomes:UP000272659} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UMB6454 {ECO:0000313|EMBL:RRK95457.1, RC ECO:0000313|Proteomes:UP000272659}; RA Garretto A., Miller-Ensminger T., Wolfe A.J., Putonti C.; RT "E. coli isolates of the female bladder."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [37] {ECO:0000313|Proteomes:UP000278385} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_539 {ECO:0000313|Proteomes:UP000278385}; RA Goldberg B., Campos J., Tallon L., Sadzewicz L., Zhao X., Vavikolanu K., RA Mehta A., Aluvathingal J., Nadendla S., Geyer C., Nandy P., Yan Y., RA Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx tests."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [38] {ECO:0000313|EMBL:RSB71353.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FDAARGOS_539 {ECO:0000313|EMBL:RSB71353.1}; RA Johnson J., Sokurenko E., Tallon L.J., Sadzewicz L., Zhao X., RA Vavikolanu K., Mehta A., Aluvathingal J., Nadendla S., Nandy P., Yan Y., RA Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx tests."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [39] {ECO:0000313|Proteomes:UP000059691, ECO:0000313|Proteomes:UP000065249, ECO:0000313|Proteomes:UP000076551} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GN02175 {ECO:0000313|EMBL:RRO77286.1, RC ECO:0000313|Proteomes:UP000065249}, GN02766 RC {ECO:0000313|EMBL:RRO73229.1, ECO:0000313|Proteomes:UP000059691}, and RC GN05696 {ECO:0000313|EMBL:RRO48648.1, RC ECO:0000313|Proteomes:UP000076551}; RA Bethke J.H., Davidovich A., Cheng L., Lopatkin A.J., Thaden J.T., RA Fowler V.G.Jr., Xiao M., You L., Singh I., Clarke T.H., White R., RA Nguyen K., Sutton G., Fouts D.E.; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [40] {ECO:0000313|Proteomes:UP000432266, ECO:0000313|Proteomes:UP000481708, ECO:0000313|Proteomes:UP000486638} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BIOML-A391 {ECO:0000313|EMBL:MSI93686.1, RC ECO:0000313|Proteomes:UP000432266}, BIOML-A393 RC {ECO:0000313|EMBL:MSI12658.1, ECO:0000313|Proteomes:UP000486638}, and RC BIOML-A4 {ECO:0000313|EMBL:MZZ83056.1, RC ECO:0000313|Proteomes:UP000481708}; RX PubMed=31477907; DOI=.1038/s41591-019-0559-3; RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X., RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D., RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J., RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A., RA Xavier R.J., Alm E.J.; RT "A library of human gut bacterial isolates paired with longitudinal RT multiomics data enables mechanistic microbiome research."; RL Nat. Med. 25:1442-1452(2019). RN [41] {ECO:0000313|EMBL:RXB48943.1, ECO:0000313|Proteomes:UP000288730, ECO:0000313|Proteomes:UP000290055} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=29_CAASB {ECO:0000313|EMBL:RXD17520.1, RC ECO:0000313|Proteomes:UP000288730}, and 46_rectal RC {ECO:0000313|EMBL:RXB48943.1, ECO:0000313|Proteomes:UP000290055}; RA Potter R., Zou Z., Henderson J., Dantas G.; RT "Genomic analysis of febrile catheter-associated UTI E. coli isolates."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. RN [42] {ECO:0000313|EMBL:QBR58174.1, ECO:0000313|Proteomes:UP000325868} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=04-00955 {ECO:0000313|EMBL:QBR58174.1, RC ECO:0000313|Proteomes:UP000325868}; RA Gati N.S., Middendorf-Bauchart B., Dobrindt U., Karch H., Mellmann A.; RT "Origin and evolution of heteropathogenic E. coli of sequence type 141."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. RN [43] {ECO:0000313|EMBL:QAY43816.1, ECO:0000313|Proteomes:UP000291743, ECO:0000313|Proteomes:UP000291865} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=U12A {ECO:0000313|EMBL:QAY43816.1, RC ECO:0000313|Proteomes:UP000291865}, and U14A RC {ECO:0000313|EMBL:QAZ90238.1, ECO:0000313|Proteomes:UP000291743}; RA Forde B.M., Roberts L.W., Phan M.-D., Peters K.M., Fleming B.A., RA Russell C.W., Lenherr S.M., Myers J.B., Barker A.P., Fisher M.A., RA Chong T.-M., Yin W.-F., Chan K.-G., Schembri M.A., Mulvey M.A., RA Beatson S.A.; RT "Personalised genomic investigation reveals strain heterogeneity during RT chronic infection with E. coli ST131."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. RN [44] {ECO:0000313|EMBL:TIJ92825.1, ECO:0000313|Proteomes:UP000306171} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Broiler parent78 {ECO:0000313|EMBL:TIJ92825.1, RC ECO:0000313|Proteomes:UP000306171}; RA Poulsen L.; RT "Are subpopulations of E. coli responsible for the pathological RT manifestation of salpingitis in egg laying hens?"; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [45] {ECO:0000313|Proteomes:UP000297269, ECO:0000313|Proteomes:UP000297588, ECO:0000313|Proteomes:UP000297680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=URMC_112 {ECO:0000313|EMBL:TFS85004.1, RC ECO:0000313|Proteomes:UP000320308}, URMC_147 RC {ECO:0000313|EMBL:TFR22232.1, ECO:0000313|Proteomes:UP000297937}, RC URMC_150 {ECO:0000313|EMBL:TFR21606.1, RC ECO:0000313|Proteomes:UP000297680}, URMC_163 RC {ECO:0000313|EMBL:TFQ77860.1, ECO:0000313|Proteomes:UP000297840}, RC URMC_164 {ECO:0000313|EMBL:TFQ60441.1, RC ECO:0000313|Proteomes:UP000297588}, URMC_185 RC {ECO:0000313|EMBL:TFP50153.1, ECO:0000313|Proteomes:UP000297269}, RC URMC_192 {ECO:0000313|EMBL:TFP26379.1, RC ECO:0000313|Proteomes:UP000297726}, URMC_193 RC {ECO:0000313|EMBL:TFP11583.1, ECO:0000313|Proteomes:UP000297973}, RC URMC_22 {ECO:0000313|EMBL:TFP00455.1, RC ECO:0000313|Proteomes:UP000320760}, URMC_23 RC {ECO:0000313|EMBL:TFO95052.1, ECO:0000313|Proteomes:UP000318040}, RC URMC_31 {ECO:0000313|EMBL:TFO56688.1, RC ECO:0000313|Proteomes:UP000320189}, URMC_48 RC {ECO:0000313|EMBL:TFN82107.1, ECO:0000313|Proteomes:UP000320204}, RC URMC_59 {ECO:0000313|EMBL:TFN60211.1, RC ECO:0000313|Proteomes:UP000320425}, URMC_68 RC {ECO:0000313|EMBL:TFM76837.1, ECO:0000313|Proteomes:UP000315654}, RC URMC_86 {ECO:0000313|EMBL:TFM28220.1, RC ECO:0000313|Proteomes:UP000320614}, URMC_87 RC {ECO:0000313|EMBL:TFL78236.1, ECO:0000313|Proteomes:UP000320544}, and RC URMC_89 {ECO:0000313|EMBL:TFL68617.1, RC ECO:0000313|Proteomes:UP000320420}; RA Mostafa H., Pecora N.; RT "ESBL Survelliance."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [46] {ECO:0000313|EMBL:TZA23515.1, ECO:0000313|Proteomes:UP000324866} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=67I {ECO:0000313|EMBL:TZA23515.1, RC ECO:0000313|Proteomes:UP000324866}; RA Cormier A.C., Chalmer G., Cook S.R., Zaheer R., Hannon S.J., Booker C.W., RA Read R., Gow S.P., Mcallister T.A., Boerlin P.; RT "The presence and diversity of blaCTX-M among Escherichia coli from urban RT wastewater and feedlot cattle, in Alberta, Canada."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [47] {ECO:0000313|EMBL:VEW08311.1, ECO:0000313|Proteomes:UP000405344} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=13645 {ECO:0000313|EMBL:VEW08311.1, RC ECO:0000313|Proteomes:UP000405344}; RA Garza-Ramos U.; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [48] {ECO:0000313|EMBL:RYL81832.1, ECO:0000313|Proteomes:UP000291778} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SCPM-O-B-8431 {ECO:0000313|EMBL:RYL81832.1}, and RC SCPM-O-B-8431(U15) {ECO:0000313|Proteomes:UP000291778}; RA Slukin P., Fursova N., Ermolenko Z., Mayskaya N., Kislichkina A., RA Mukhina T., Sizova A., Bogun A.; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [49] {ECO:0000313|EMBL:QDN42117.1, ECO:0000313|Proteomes:UP000318738} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=131 {ECO:0000313|EMBL:QDN42117.1, RC ECO:0000313|Proteomes:UP000318738}; RA Song W.; RT "Environmental and genetic determinants of plasmid mobility in pathogenic RT Escherichia coli."; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [50] {ECO:0000313|EMBL:QDX37397.1, ECO:0000313|Proteomes:UP000315141} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PU-1 {ECO:0000313|EMBL:QDX37397.1, RC ECO:0000313|Proteomes:UP000315141}; RA Ma J., Yao H.; RT "Extracellular polysaccharide and nucleotide biosynthesis is required for RT optimal growth of porcine extraintestinal pathogenic Escherichia coli in RT swine blood."; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [51] {ECO:0000313|EMBL:QDN42117.1, ECO:0000313|Proteomes:UP000318738} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=131 {ECO:0000313|EMBL:QDN42117.1, RC ECO:0000313|Proteomes:UP000318738}; RA Bethke J.H., Davidovich A., Cheng L., Lopatkin A.J., Thaden J.T., RA Fowler V.G.Jr., Xiao M., You L.; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [52] {ECO:0000313|Proteomes:UP000431301, ECO:0000313|Proteomes:UP000433651, ECO:0000313|Proteomes:UP000434235} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=J19 {ECO:0000313|EMBL:MQR80925.1, RC ECO:0000313|Proteomes:UP000431301}, V16 {ECO:0000313|EMBL:MQR33521.1, RC ECO:0000313|Proteomes:UP000433651}, and X01 RC {ECO:0000313|EMBL:MQQ76651.1, ECO:0000313|Proteomes:UP000434235}; RA Valat C.; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [53] {ECO:0000313|EMBL:MUU91410.1, ECO:0000313|Proteomes:UP000432738} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EC702 {ECO:0000313|EMBL:MUU91410.1, RC ECO:0000313|Proteomes:UP000432738}; RA Dafopoulou K., Xavier B.B., Zarkotou O., Orfanidou M., Goossens H., RA Tsakris A., Malhotra-Kumar S., Pournaras S.; RT "Emergence of colistin resistance in the highly virulent Escherichia coli RT ST131 H30Rx clone in Greece."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [54] {ECO:0000313|EMBL:MWD96924.1, ECO:0000313|Proteomes:UP000429662, ECO:0000313|Proteomes:UP000433654} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OM13c {ECO:0000313|EMBL:MWD96924.1, RC ECO:0000313|Proteomes:UP000429662}, and OM1c RC {ECO:0000313|EMBL:MWE06174.1, ECO:0000313|Proteomes:UP000433654}; RA Kutilova I.; RT "Extended-spectrum beta-lactamase-producing Escherichia coli and antibiotic RT resistance in municipal and hospital waters."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [55] {ECO:0000313|EMBL:MWG09083.1, ECO:0000313|Proteomes:UP000429722} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A2FCC14 {ECO:0000313|EMBL:MWG09083.1, RC ECO:0000313|Proteomes:UP000429722}; RA Scaccia N., Vaz-Moreira I., Manaia C.M.; RT "Persistence of wastewater antibiotic resistant bacteria and their genes in RT human fecal material."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [56] {ECO:0000313|EMBL:NDR90784.1, ECO:0000313|Proteomes:UP000471490} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 11230 {ECO:0000313|EMBL:NDR90784.1, RC ECO:0000313|Proteomes:UP000471490}; RX PubMed=32021174; RA Kedziora A., Wernecki M., Korzekwa K., Speruda M., Gerasymchuk Y., RA Lukowiak A., Bugla-Ploskonska G.; RT "Consequences Of Long-Term Bacteria's Exposure To Silver Nanoformulations RT With Different PhysicoChemical Properties."; RL Int J Nanomedicine 15:199-213(2020). RN [57] {ECO:0000313|EMBL:NES48343.1, ECO:0000313|Proteomes:UP000474145} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ExIIa_T32_C2 {ECO:0000313|EMBL:NES48343.1, RC ECO:0000313|Proteomes:UP000474145}; RA Bernasconi O.J., Campos-Madueno E.I., Dona V., Perreten V., Carattoli A., RA Endimiani A.; RT "Investigating the Use of Bacteriophages as New Decolonization Strategy for RT Intestinal Carriage of CTX-M-15-producing ST131 Escherichia coli: an In RT Vitro Continuous Culture System Model."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with CC quinone as electron acceptor. {ECO:0000256|ARBA:ARBA00003125, CC ECO:0000256|HAMAP-Rule:MF_00225}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(S)-dihydroorotate + a quinone = a quinol + orotate; CC Xref=Rhea:RHEA:30187, ChEBI:CHEBI:24646, ChEBI:CHEBI:30839, CC ChEBI:CHEBI:30864, ChEBI:CHEBI:132124; EC=1.3.5.2; CC Evidence={ECO:0000256|ARBA:ARBA00001532, ECO:0000256|HAMAP- CC Rule:MF_00225}; CC -!- COFACTOR: CC Name=FMN; Xref=ChEBI:CHEBI:58210; CC Evidence={ECO:0000256|HAMAP-Rule:MF_00225}; CC Note=Binds 1 FMN per subunit. {ECO:0000256|HAMAP-Rule:MF_00225}; CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; CC orotate from (S)-dihydroorotate (quinone route): step 1/1. CC {ECO:0000256|ARBA:ARBA00005161, ECO:0000256|HAMAP-Rule:MF_00225}. CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00225}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202, CC ECO:0000256|HAMAP-Rule:MF_00225}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|HAMAP-Rule:MF_00225}. CC -!- SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 2 CC subfamily. {ECO:0000256|ARBA:ARBA00005359, ECO:0000256|HAMAP- CC Rule:MF_00225}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP010876; AJO82901.1; -; Genomic_DNA. DR EMBL; CP024717; ATV46927.1; -; Genomic_DNA. DR EMBL; CP025401; AUG92566.1; -; Genomic_DNA. DR EMBL; CP020545; AWG05874.1; -; Genomic_DNA. DR EMBL; CP032201; AXZ04039.1; -; Genomic_DNA. DR EMBL; CP023826; AZH38259.1; -; Genomic_DNA. DR EMBL; CYBW01000005; CTU42337.1; -; Genomic_DNA. DR EMBL; AAAAMF010000004; EAA1121967.1; -; Genomic_DNA. DR EMBL; AAAAPF010000014; EAA1498699.1; -; Genomic_DNA. DR EMBL; AAAAQA010000011; EAA1585502.1; -; Genomic_DNA. DR EMBL; AAAARR010000004; EAA1819359.1; -; Genomic_DNA. DR EMBL; AAAHEK010000006; EAC1931886.1; -; Genomic_DNA. DR EMBL; AAAHEN010000001; EAC1988847.1; -; Genomic_DNA. DR EMBL; BFJD01000015; GCR90881.1; -; Genomic_DNA. DR EMBL; BFLL01000014; GCS72510.1; -; Genomic_DNA. DR EMBL; BFRA01000089; GDA13922.1; -; Genomic_DNA. DR EMBL; RDTI01000010; KAA1815415.1; -; Genomic_DNA. DR EMBL; RDTG01000003; KAA1815952.1; -; Genomic_DNA. DR EMBL; RDTH01000003; KAA1824295.1; -; Genomic_DNA. DR EMBL; REBC01000009; KAA1831513.1; -; Genomic_DNA. DR EMBL; REBD01000001; KAA1841174.1; -; Genomic_DNA. DR EMBL; REBE01000001; KAA1873646.1; -; Genomic_DNA. DR EMBL; RDTR01000013; KAA1887052.1; -; Genomic_DNA. DR EMBL; RDTU01000002; KAA1887574.1; -; Genomic_DNA. DR EMBL; RDUA01000010; KAA1923801.1; -; Genomic_DNA. DR EMBL; RDUF01000002; KAA1952878.1; -; Genomic_DNA. DR EMBL; RDUI01000002; KAA1981218.1; -; Genomic_DNA. DR EMBL; RDVE01000003; KAA2091501.1; -; Genomic_DNA. DR EMBL; RDVD01000008; KAA2097765.1; -; Genomic_DNA. DR EMBL; RDVG01000016; KAA2103205.1; -; Genomic_DNA. DR EMBL; RDVK01000002; KAA2116229.1; -; Genomic_DNA. DR EMBL; RDVP01000001; KAA2149004.1; -; Genomic_DNA. DR EMBL; RDVQ01000001; KAA2162363.1; -; Genomic_DNA. DR EMBL; REBJ01000003; KAA2164745.1; -; Genomic_DNA. DR EMBL; RDVS01000001; KAA2178577.1; -; Genomic_DNA. DR EMBL; RDVY01000006; KAA2188384.1; -; Genomic_DNA. DR EMBL; RDVW01000017; KAA2192526.1; -; Genomic_DNA. DR EMBL; RDTJ01000013; KAA2308278.1; -; Genomic_DNA. DR EMBL; QXNO01000001; KAB1250772.1; -; Genomic_DNA. DR EMBL; LNIP01000047; KSZ12912.1; -; Genomic_DNA. DR EMBL; ROEU01000003; MGR71748.1; -; Genomic_DNA. DR EMBL; ROAL01000013; MIB61652.1; -; Genomic_DNA. DR EMBL; WIKG01000006; MQQ76651.1; -; Genomic_DNA. DR EMBL; WIKH01000005; MQR33521.1; -; Genomic_DNA. DR EMBL; WIKL01000004; MQR80925.1; -; Genomic_DNA. DR EMBL; WKTT01000017; MSI12658.1; -; Genomic_DNA. DR EMBL; WKTV01000005; MSI93686.1; -; Genomic_DNA. DR EMBL; WKKQ01000007; MUU91410.1; -; Genomic_DNA. DR EMBL; WSWB01000001; MWD96924.1; -; Genomic_DNA. DR EMBL; WSWK01000001; MWE06174.1; -; Genomic_DNA. DR EMBL; WSZB01000002; MWG09083.1; -; Genomic_DNA. DR EMBL; WXOK01000018; MZZ83056.1; -; Genomic_DNA. DR EMBL; VLTB01000090; NDR90784.1; -; Genomic_DNA. DR EMBL; JAAHTF010000004; NES48343.1; -; Genomic_DNA. DR EMBL; NGSK01000001; OUG34981.1; -; Genomic_DNA. DR EMBL; PENJ01000002; PIM24931.1; -; Genomic_DNA. DR EMBL; PSNQ01000007; PPE30888.1; -; Genomic_DNA. DR EMBL; QGMN01000002; PWR58818.1; -; Genomic_DNA. DR EMBL; CP035476; QAY43816.1; -; Genomic_DNA. DR EMBL; CP035516; QAZ90238.1; -; Genomic_DNA. DR EMBL; CP035498; QBR58174.1; -; Genomic_DNA. DR EMBL; CP041578; QDN42117.1; -; Genomic_DNA. DR EMBL; CP042246; QDX37397.1; -; Genomic_DNA. DR EMBL; QLAC01000002; RAH24927.1; -; Genomic_DNA. DR EMBL; NHYU01000005; RAX67975.1; -; Genomic_DNA. DR EMBL; NHYY01000001; RAX86232.1; -; Genomic_DNA. DR EMBL; NFSN01000004; RBU23308.1; -; Genomic_DNA. DR EMBL; QOEN01000002; RBX75537.1; -; Genomic_DNA. DR EMBL; QRIX01000008; RHG97426.1; -; Genomic_DNA. DR EMBL; QXHA01000556; RIB42216.1; -; Genomic_DNA. DR EMBL; MCLR01000012; ROL26534.1; -; Genomic_DNA. DR EMBL; RRUU01000004; RRK95457.1; -; Genomic_DNA. DR EMBL; LVSP02000001; RRO48648.1; -; Genomic_DNA. DR EMBL; LQVG02000001; RRO73229.1; -; Genomic_DNA. DR EMBL; LQSL02000003; RRO77286.1; -; Genomic_DNA. DR EMBL; RKJN01000003; RSB71353.1; -; Genomic_DNA. DR EMBL; SCIX01000003; RXB48943.1; -; Genomic_DNA. DR EMBL; SCJN01000021; RXD17520.1; -; Genomic_DNA. DR EMBL; SERV01000008; RYL81832.1; -; Genomic_DNA. DR EMBL; UFXW01000004; STC88669.1; -; Genomic_DNA. DR EMBL; UFZD01000005; STE09924.1; -; Genomic_DNA. DR EMBL; UGBW01000003; STH83353.1; -; Genomic_DNA. DR EMBL; UGFV01000001; STN18645.1; -; Genomic_DNA. DR EMBL; LS992180; SYX31712.1; -; Genomic_DNA. DR EMBL; MTXY01000039; TFA39578.1; -; Genomic_DNA. DR EMBL; RZGA01000008; TFL68617.1; -; Genomic_DNA. DR EMBL; RZFY01000013; TFL78236.1; -; Genomic_DNA. DR EMBL; RZFX01000002; TFM28220.1; -; Genomic_DNA. DR EMBL; RZFE01000006; TFM76837.1; -; Genomic_DNA. DR EMBL; RZEU01000001; TFN60211.1; -; Genomic_DNA. DR EMBL; RZEK01000009; TFN82107.1; -; Genomic_DNA. DR EMBL; RZDW01000002; TFO56688.1; -; Genomic_DNA. DR EMBL; RZDP01000005; TFO95052.1; -; Genomic_DNA. DR EMBL; RZDO01000001; TFP00455.1; -; Genomic_DNA. DR EMBL; RZDI01000002; TFP11583.1; -; Genomic_DNA. DR EMBL; RZDH01000001; TFP26379.1; -; Genomic_DNA. DR EMBL; RZCZ01000001; TFP50153.1; -; Genomic_DNA. DR EMBL; RZCE01000017; TFQ60441.1; -; Genomic_DNA. DR EMBL; RZCD01000001; TFQ77860.1; -; Genomic_DNA. DR EMBL; RZBU01000004; TFR21606.1; -; Genomic_DNA. DR EMBL; RZBR01000001; TFR22232.1; -; Genomic_DNA. DR EMBL; RZAK01000002; TFS85004.1; -; Genomic_DNA. DR EMBL; SSQV01000041; TIJ92825.1; -; Genomic_DNA. DR EMBL; QYND01000033; TXW73614.1; -; Genomic_DNA. DR EMBL; QFTS01000011; TYD76171.1; -; Genomic_DNA. DR EMBL; SJJI01000001; TZA23515.1; -; Genomic_DNA. DR EMBL; CAACXM010000217; VEW08311.1; -; Genomic_DNA. DR EMBL; CAADIS010000003; VFS13731.1; -; Genomic_DNA. DR EMBL; CABEEY010000003; VTR21303.1; -; Genomic_DNA. DR RefSeq; WP_001295934.1; NZ_WWEV01000082.1. DR SMR; E2QJE9; -. DR EnsemblBacteria; AJO82901; AJO82901; SY51_05320. DR EnsemblBacteria; ALD25881; ALD25881; AN206_16190. DR EnsemblBacteria; AMX16504; AMX16504; A4X18_24825. DR EnsemblBacteria; ANK31670; ANK31670; WM48_04895. DR EnsemblBacteria; CRL91625; CRL91625; AL505_70083. DR EnsemblBacteria; CTU42337; CTU42337; ERS085406_01231. DR EnsemblBacteria; KSZ12912; KSZ12912; APU18_21825. DR EnsemblBacteria; KXG98019; KXG98019; HMPREF3041_01381. DR EnsemblBacteria; KXI04203; KXI04203; AXE68_07220. DR EnsemblBacteria; OAO74992; OAO74992; OK10_05430. DR GeneID; 49585310; -. DR PATRIC; fig|562.10480.peg.3232; -. DR OrthoDB; 1109542at2; -. DR UniPathway; UPA00070; UER00946. DR Proteomes; UP000032290; Chromosome. DR Proteomes; UP000043018; Unassembled WGS sequence. DR Proteomes; UP000053450; Unassembled WGS sequence. DR Proteomes; UP000059691; Unassembled WGS sequence. DR Proteomes; UP000065249; Unassembled WGS sequence. DR Proteomes; UP000076551; Unassembled WGS sequence. DR Proteomes; UP000194954; Unassembled WGS sequence. DR Proteomes; UP000229602; Unassembled WGS sequence. DR Proteomes; UP000231009; Chromosome. DR Proteomes; UP000233584; Chromosome. DR Proteomes; UP000238807; Unassembled WGS sequence. DR Proteomes; UP000245692; Unassembled WGS sequence. DR Proteomes; UP000249503; Unassembled WGS sequence. DR Proteomes; UP000250807; Unassembled WGS sequence. DR Proteomes; UP000251114; Unassembled WGS sequence. DR Proteomes; UP000252181; Unassembled WGS sequence. DR Proteomes; UP000253299; Unassembled WGS sequence. DR Proteomes; UP000254647; Unassembled WGS sequence. DR Proteomes; UP000254730; Unassembled WGS sequence. DR Proteomes; UP000255093; Unassembled WGS sequence. DR Proteomes; UP000255118; Unassembled WGS sequence. DR Proteomes; UP000264112; Chromosome. DR Proteomes; UP000271175; Unassembled WGS sequence. DR Proteomes; UP000272659; Unassembled WGS sequence. DR Proteomes; UP000278385; Unassembled WGS sequence. DR Proteomes; UP000280867; Chromosome. DR Proteomes; UP000280919; Unassembled WGS sequence. DR Proteomes; UP000284508; Unassembled WGS sequence. DR Proteomes; UP000284643; Unassembled WGS sequence. DR Proteomes; UP000285976; Unassembled WGS sequence. DR Proteomes; UP000288730; Unassembled WGS sequence. DR Proteomes; UP000290055; Unassembled WGS sequence. DR Proteomes; UP000291743; Chromosome. DR Proteomes; UP000291778; Unassembled WGS sequence. DR Proteomes; UP000291865; Chromosome. DR Proteomes; UP000294333; Chromosome 1. DR Proteomes; UP000297269; Unassembled WGS sequence. DR Proteomes; UP000297588; Unassembled WGS sequence. DR Proteomes; UP000297637; Unassembled WGS sequence. DR Proteomes; UP000297680; Unassembled WGS sequence. DR Proteomes; UP000297726; Unassembled WGS sequence. DR Proteomes; UP000297840; Unassembled WGS sequence. DR Proteomes; UP000297937; Unassembled WGS sequence. DR Proteomes; UP000297973; Unassembled WGS sequence. DR Proteomes; UP000298985; Unassembled WGS sequence. DR Proteomes; UP000303541; Unassembled WGS sequence. DR Proteomes; UP000304638; Unassembled WGS sequence. DR Proteomes; UP000306171; Unassembled WGS sequence. DR Proteomes; UP000315141; Chromosome. DR Proteomes; UP000315654; Unassembled WGS sequence. DR Proteomes; UP000318040; Unassembled WGS sequence. DR Proteomes; UP000318738; Chromosome. DR Proteomes; UP000320189; Unassembled WGS sequence. DR Proteomes; UP000320204; Unassembled WGS sequence. DR Proteomes; UP000320308; Unassembled WGS sequence. DR Proteomes; UP000320420; Unassembled WGS sequence. DR Proteomes; UP000320425; Unassembled WGS sequence. DR Proteomes; UP000320544; Unassembled WGS sequence. DR Proteomes; UP000320614; Unassembled WGS sequence. DR Proteomes; UP000320760; Unassembled WGS sequence. DR Proteomes; UP000323211; Unassembled WGS sequence. DR Proteomes; UP000323638; Unassembled WGS sequence. DR Proteomes; UP000324147; Chromosome. DR Proteomes; UP000324866; Unassembled WGS sequence. DR Proteomes; UP000325868; Chromosome. DR Proteomes; UP000329907; Unassembled WGS sequence. DR Proteomes; UP000336005; Unassembled WGS sequence. DR Proteomes; UP000344880; Unassembled WGS sequence. DR Proteomes; UP000353002; Unassembled WGS sequence. DR Proteomes; UP000360051; Unassembled WGS sequence. DR Proteomes; UP000372890; Unassembled WGS sequence. DR Proteomes; UP000373733; Unassembled WGS sequence. DR Proteomes; UP000396867; Unassembled WGS sequence. DR Proteomes; UP000399267; Unassembled WGS sequence. DR Proteomes; UP000400300; Unassembled WGS sequence. DR Proteomes; UP000403478; Unassembled WGS sequence. DR Proteomes; UP000405220; Unassembled WGS sequence. DR Proteomes; UP000405344; Unassembled WGS sequence. DR Proteomes; UP000406392; Unassembled WGS sequence. DR Proteomes; UP000408257; Unassembled WGS sequence. DR Proteomes; UP000408798; Unassembled WGS sequence. DR Proteomes; UP000413318; Unassembled WGS sequence. DR Proteomes; UP000421033; Unassembled WGS sequence. DR Proteomes; UP000429274; Unassembled WGS sequence. DR Proteomes; UP000429662; Unassembled WGS sequence. DR Proteomes; UP000429722; Unassembled WGS sequence. DR Proteomes; UP000430254; Unassembled WGS sequence. DR Proteomes; UP000430570; Unassembled WGS sequence. DR Proteomes; UP000431301; Unassembled WGS sequence. DR Proteomes; UP000431974; Unassembled WGS sequence. DR Proteomes; UP000432266; Unassembled WGS sequence. DR Proteomes; UP000432531; Unassembled WGS sequence. DR Proteomes; UP000432738; Unassembled WGS sequence. DR Proteomes; UP000433651; Unassembled WGS sequence. DR Proteomes; UP000433654; Unassembled WGS sequence. DR Proteomes; UP000433772; Unassembled WGS sequence. DR Proteomes; UP000433794; Unassembled WGS sequence. DR Proteomes; UP000434235; Unassembled WGS sequence. DR Proteomes; UP000434336; Unassembled WGS sequence. DR Proteomes; UP000434743; Unassembled WGS sequence. DR Proteomes; UP000441039; Unassembled WGS sequence. DR Proteomes; UP000448800; Unassembled WGS sequence. DR Proteomes; UP000448912; Unassembled WGS sequence. DR Proteomes; UP000471490; Unassembled WGS sequence. DR Proteomes; UP000474145; Unassembled WGS sequence. DR Proteomes; UP000477630; Unassembled WGS sequence. DR Proteomes; UP000478303; Unassembled WGS sequence. DR Proteomes; UP000481708; Unassembled WGS sequence. DR Proteomes; UP000486638; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004152; F:dihydroorotate dehydrogenase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd04738; DHOD_2_like; 1. DR Gene3D; 3.20.20.70; -; 1. DR HAMAP; MF_00225; DHO_dh_type2; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR005720; Dihydroorotate_DH. DR InterPro; IPR012135; Dihydroorotate_DH_1_2. DR InterPro; IPR005719; Dihydroorotate_DH_2. DR InterPro; IPR001295; Dihydroorotate_DH_CS. DR Pfam; PF01180; DHO_dh; 1. DR PIRSF; PIRSF000164; DHO_oxidase; 1. DR TIGRFAMs; TIGR01036; pyrD_sub2; 1. DR PROSITE; PS00911; DHODEHASE_1; 1. DR PROSITE; PS00912; DHODEHASE_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00225}; KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|HAMAP- KW Rule:MF_00225}; KW FMN {ECO:0000256|ARBA:ARBA00022643, ECO:0000256|HAMAP-Rule:MF_00225}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00225}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP- KW Rule:MF_00225, ECO:0000313|EMBL:AJO82901.1}; KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975, ECO:0000256|HAMAP- KW Rule:MF_00225}. FT DOMAIN 47..335 FT /note="DHO_dh" FT /evidence="ECO:0000259|Pfam:PF01180" FT NP_BIND 62..66 FT /note="FMN" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT NP_BIND 318..319 FT /note="FMN" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT REGION 111..115 FT /note="Substrate binding" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT REGION 246..247 FT /note="Substrate binding" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT ACT_SITE 175 FT /note="Nucleophile" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 66 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 86 FT /note="FMN; via amide nitrogen" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 139 FT /note="FMN" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 172 FT /note="FMN" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 172 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 177 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 217 FT /note="FMN" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 245 FT /note="FMN; via carbonyl oxygen" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 268 FT /note="FMN; via amide nitrogen" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" FT BINDING 297 FT /note="FMN; via amide nitrogen" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00225" SQ SEQUENCE 336 AA; 36818 MW; A8B92A71ED2EED5B CRC64; MYYPFVRKAL FQLDPERAHE FTFQQLRRIT GTPFEALVRQ KVPAKPVNCM GLTFKNPLGL AAGLDKDGEC IDALGAMGFG SIEIGTVTPR PQPGNDKPRL FRLVDAEGLI NRMGFNNLGV DNLVENVKKA HYDGVLGINI GKNKDTPVEQ GKDDYLICME KIYAYAGYIA INISSPNTPG LRTLQYGEAL DDLLTAIKNK QNDLQVMHHK YVPIAVKIAP DLSEEELIQV ADSLVRHNID GVIATNTTLD RSLVQGMKNC DQTGGLSGRP LQLKSTEIIR RLSQELNGRL PIIGVGGIDS VIAAREKIAA GASLVQIYSG FIFKGPPLIK EIVTHI //