ID E2F3B7_HELPX Unreviewed; 149 AA. AC E2F3B7; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 07-OCT-2020, entry version 14. DE SubName: Full=VacA {ECO:0000313|EMBL:ADK63229.1}; DE Flags: Fragment; GN Name=vacA {ECO:0000313|EMBL:ADK63229.1}; OS Helicobacter pylori (Campylobacter pylori). OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=210 {ECO:0000313|EMBL:ADK63229.1}; RN [1] {ECO:0000313|EMBL:ADK63229.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=K210 {ECO:0000313|EMBL:ADK63229.1}; RX PubMed=21084502; DOI=10.1128/JCM.01782-10; RA Jones K.R., Jang S., Chang J.Y., Kim J., Chung I.S., Olsen C.H., RA Merrell D.S., Cha J.H.; RT "Polymorphisms in the intermediate region of VacA impact Helicobacter RT pylori-induced disease development."; RL J. Clin. Microbiol. 49:101-110(2011). CC -!- SUBCELLULAR LOCATION: Cell outer membrane CC {ECO:0000256|ARBA:ARBA00004571}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004571}. Cell surface CC {ECO:0000256|ARBA:ARBA00004241}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. Periplasm CC {ECO:0000256|ARBA:ARBA00004418}. Secreted CC {ECO:0000256|ARBA:ARBA00004613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM047575; ADK63229.1; -; Genomic_DNA. DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. DR GO; GO:0009405; P:pathogenesis; IEA:InterPro. DR InterPro; IPR003842; Vacuolating_cytotoxin. DR Pfam; PF02691; VacA; 1. DR PRINTS; PR01656; VACCYTOTOXIN. PE 4: Predicted; FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ADK63229.1" FT NON_TER 149 FT /evidence="ECO:0000313|EMBL:ADK63229.1" SQ SEQUENCE 149 AA; 16315 MW; 5A7C70D95A463BE2 CRC64; WGNAARHYWV KGGQWNKLEV DMKDAVGTYK LSGLRNYTGG DLDVNMQKAT LRLGQFNGNS FTSFKDSADR TTRVDFNAKN ISIDNFLEIN NRVGSGAGRK ASSTVLTLQA SEGITSDKNA EISLYDGATL NLASNSVKLM GNVWMGRLQ //