ID E2DH63_MERCP Unreviewed; 204 AA. AC E2DH63; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 05-APR-2011, entry version 5. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE Flags: Fragment; GN Name=COI; OS Merluccius capensis (Shallow-water Cape hake) (Gadus merluccius). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Paracanthopterygii; Gadiformes; Merlucciidae; OC Merlucciinae; Merluccius. OX NCBI_TaxID=89947; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C1; RA Casa M.F., Garcia-Vazquez E., Machado-Schiaffino G.; RT "Detection of mislabelling in hake products based on COI sequences."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ988405; ADK55082.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR InterPro; IPR000883; Cyt_c_oxidase_su1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. FT NON_TER 1 1 FT NON_TER 204 204 SQ SEQUENCE 204 AA; 21564 MW; EA2C4FE5CF43241A CRC64; AWAGMVGTAL SLLIRAELSQ PGALLGDDQI YNVIVTAHAF VMIFFMVMPL MIGGFGNWLV PLMIGAPDMA FPRMNNMSFW LLPPSFLLLL ASSGVEAGAG TGWTVYPPLA SNLAHAGASV DLTIFSLHLA GVSSILGAIN FITTIINMKP PAISQYQTPL FVWSVLITAV LLLLSLPVLA AGITMLLTDR NLNTSFFDPA GGGD //