ID E1TZ61_9INFA Unreviewed; 121 AA. AC E1TZ61; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 11-MAY-2016, entry version 16. DE RecName: Full=Nuclear export protein {ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00129351}; DE Short=NEP {ECO:0000256|RuleBase:RU362104}; DE AltName: Full=Non-structural protein 2 {ECO:0000256|RuleBase:RU362104}; GN Name=NEP {ECO:0000313|EMBL:ADO21054.1}; GN Synonyms=NS {ECO:0000256|RuleBase:RU362104}; OS Influenza A virus (A/swine/Guangxi/10/2007(H9N2)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=892007 {ECO:0000313|EMBL:ADO21054.1}; RN [1] {ECO:0000313|EMBL:ADO21054.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/swine/Guangxi/10/2007 {ECO:0000313|EMBL:ADO21054.1}; RA Yu H., Zhou Y.-J., Li G.-X., Tong G.-Z.; RT "Genetic diversity of H9N2 influenza viruses from pigs in China: a RT potential threat to human health?"; RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs CC (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs CC complexes and the nuclear export machinery of the cell. Possesses CC no intrinsic RNA-binding activity, but includes a C-terminal M1- CC binding domain. This domain is believed to allow recognition of CC RNPs to which the M1 protein is bound. Because the M1 protein is CC not available in large quantities until the later stages of CC infection, such an indirect recognition mechanism probably ensures CC that genomic RNPs are not exported from the nucleus before CC sufficient quantities of viral mRNA and progeny genomic RNA have CC been synthesized. Furthermore, the RNPs enters the cytoplasm only CC when they have associated with the M1 protein that is necessary to CC guide them to the plasma membrane. May down-regulate viral RNA CC synthesis when overproduced. {ECO:0000256|RuleBase:RU362104, CC ECO:0000256|SAAS:SAAS00129355}. CC -!- SUBUNIT: Binds M1 protein. May interact with host nucleoporin CC RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|RuleBase:RU362104}. CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00589355}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU362104}. Host CC nucleus {ECO:0000256|RuleBase:RU362104}. CC -!- SIMILARITY: Belongs to the influenza viruses NEP family. CC {ECO:0000256|RuleBase:RU362104}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY075058; ADO21054.1; -; Viral_cRNA. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0006405; P:RNA export from nucleus; IEA:InterPro. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR InterPro; IPR000968; Flu_NS2. DR Pfam; PF00601; Flu_NS2; 1. PE 3: Inferred from homology; KW Host nucleus {ECO:0000256|RuleBase:RU362104, KW ECO:0000256|SAAS:SAAS00483614}; KW Host-virus interaction {ECO:0000256|RuleBase:RU362104, KW ECO:0000256|SAAS:SAAS00483594}; KW Transport {ECO:0000256|RuleBase:RU362104, KW ECO:0000256|SAAS:SAAS00483575}; KW Virion {ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00483607}. SQ SEQUENCE 121 AA; 14252 MW; BBE06F887CF870B4 CRC64; MDSNTVSSFQ DILMRMSKMQ LGSSSEDLNG MITQFESLKL YRDSLGEAAM RMGDLHSLQS RNGKWRAQLS QKFEEIRWLI EEVRHRLKIT ENSFEQITFM QALQLLLEVE QEIRTFSFQL I //