ID E1JJ45_DROME Unreviewed; 493 AA. AC E1JJ45; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 25-APR-2018, entry version 72. DE SubName: Full=Hephaestus, isoform Q {ECO:0000313|EMBL:ACZ95082.1}; GN Name=heph {ECO:0000313|EMBL:ACZ95082.1, GN ECO:0000313|FlyBase:FBgn0011224}; GN Synonyms=CG2094 {ECO:0000313|EMBL:ACZ95082.1}, CG2290 GN {ECO:0000313|EMBL:ACZ95082.1}, Dmel\CG31000 GN {ECO:0000313|EMBL:ACZ95082.1}, DmPTB {ECO:0000313|EMBL:ACZ95082.1}, GN dmPTB {ECO:0000313|EMBL:ACZ95082.1}, dPTB GN {ECO:0000313|EMBL:ACZ95082.1}, ema {ECO:0000313|EMBL:ACZ95082.1}, HEPH GN {ECO:0000313|EMBL:ACZ95082.1}, Heph {ECO:0000313|EMBL:ACZ95082.1}, GN hnRNP I {ECO:0000313|EMBL:ACZ95082.1}, l(3)03429 GN {ECO:0000313|EMBL:ACZ95082.1}, l(3)j11B9 GN {ECO:0000313|EMBL:ACZ95082.1}, PTB {ECO:0000313|EMBL:ACZ95082.1}, Ptb GN {ECO:0000313|EMBL:ACZ95082.1}, ptb {ECO:0000313|EMBL:ACZ95082.1}; GN ORFNames=CG31000 {ECO:0000313|EMBL:ACZ95082.1, GN ECO:0000313|FlyBase:FBgn0011224}, Dmel_CG31000 GN {ECO:0000313|EMBL:ACZ95082.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ACZ95082.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ACZ95082.1; -; Genomic_DNA. DR RefSeq; NP_001163789.1; NM_001170318.2. DR UniGene; Dm.19417; -. DR ProteinModelPortal; E1JJ45; -. DR SMR; E1JJ45; -. DR IntAct; E1JJ45; 1. DR PRIDE; E1JJ45; -. DR EnsemblMetazoa; FBtr0085887; FBpp0085246; FBgn0011224. DR EnsemblMetazoa; FBtr0300265; FBpp0289493; FBgn0011224. DR GeneID; 48571; -. DR CTD; 9843; -. DR FlyBase; FBgn0011224; heph. DR eggNOG; KOG1190; Eukaryota. DR eggNOG; ENOG410XPMZ; LUCA. DR GeneTree; ENSGT00550000074508; -. DR OMA; SEECAQT; -. DR OrthoDB; EOG091G0Z5R; -. DR Reactome; R-DME-6803529; FGFR2 alternative splicing. DR Reactome; R-DME-72163; mRNA Splicing - Major Pathway. DR Reactome; R-DME-72203; Processing of Capped Intron-Containing Pre-mRNA. DR ChiTaRS; heph; fly. DR GenomeRNAi; 48571; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0011224; -. DR ExpressionAtlas; E1JJ45; differential. DR Genevisible; E1JJ45; DM. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005829; C:cytosol; HDA:FlyBase. DR GO; GO:0030529; C:intracellular ribonucleoprotein complex; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; HDA:FlyBase. DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:FlyBase. DR GO; GO:0003729; F:mRNA binding; ISS:FlyBase. DR GO; GO:0000900; F:translation repressor activity, mRNA regulatory element binding; IMP:FlyBase. DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase. DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase. DR GO; GO:0006397; P:mRNA processing; IEA:InterPro. DR GO; GO:0007319; P:negative regulation of oskar mRNA translation; IMP:FlyBase. DR GO; GO:0008103; P:oocyte microtubule cytoskeleton polarization; IMP:FlyBase. DR GO; GO:0007291; P:sperm individualization; IMP:FlyBase. DR GO; GO:0007286; P:spermatid development; IMP:FlyBase. DR CDD; cd12693; RRM2_PTBP1_like; 1. DR Gene3D; 3.30.70.330; -; 4. DR InterPro; IPR006536; HnRNP-L/PTB. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR034798; PTBP1/2/3_RRM2. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR Pfam; PF00076; RRM_1; 1. DR SMART; SM00360; RRM; 3. DR SUPFAM; SSF54928; SSF54928; 3. DR TIGRFAMs; TIGR01649; hnRNP-L_PTB; 1. DR PROSITE; PS50102; RRM; 3. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E1JJ45}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}. FT DOMAIN 110 186 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 299 373 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 416 491 RRM. {ECO:0000259|PROSITE:PS50102}. SQ SEQUENCE 493 AA; 53384 MW; 1191274C89562CF0 CRC64; MADEISATSM VSCYTVTPPQ MRGRMVYVQF SNHRELKTDQ GHNNSTAHSD YSVQSPASGS PLPLSAAANA TSNNANSSSD SNSAMGILQN TSAVNAGGNT NAAGGPNTVL RVIVESLMYP VSLDILHQIF QRYGKVLKIV TFTKNNSFQA LIQYPDANSA QHAKSLLDGQ NIYNGCCTLR IDNSKLTALN VKYNNDKSRD FTNPALPPGE PGVDIMPTAG GLMNTNDLLL IAARQRPSLS GDKIVNGLGA PGVLPPFALG LGTPLTGGYN NALPNLAAFS LANSGALQTT APAMRGYSNV LLVSNLNEEM VTPDALFTLF GVYGDVQRVK ILYNKKDSAL IQMAEPQQAY LAMSHLDKLR LWGKPIRVMA SKHQAVQLPK EGQPDAGLTR DYSQNPLHRF KKPGSKNYQN IYPPSATLHL SNIPSSCSED DIKEAFTSNS FEVKAFKFFP KDRKMALLQL LSVEEAVLAL IKMHNHQLSE SNHLRVSFSK SNI //