ID E1JJ45_DROME Unreviewed; 493 AA. AC E1JJ45; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 13-JUN-2012, entry version 15. DE SubName: Full=Hephaestus, isoform Q; GN Name=heph; ORFNames=Dmel_CG31000; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426070; PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426071; PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426065; PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL (er) Genome Biol. 3 (12), RESEARCH0079 (2002). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ACZ95082.1; -; Genomic_DNA. DR RefSeq; NP_001163789.1; NM_001170318.1. DR UniGene; Dm.19417; -. DR ProteinModelPortal; E1JJ45; -. DR SMR; E1JJ45; 1-40, 104-210, 298-493. DR EnsemblMetazoa; FBtr0300265; FBpp0289493; FBgn0011224. DR GeneID; 48571; -. DR KEGG; dme:Dmel_CG31000; -. DR CTD; 9843; -. DR FlyBase; FBgn0011224; heph. DR GeneTree; ENSGT00550000074508; -. DR KO; K14948; -. DR NextBio; 839481; -. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0030529; C:ribonucleoprotein complex; IDA:FlyBase. DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:FlyBase. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0008187; F:poly-pyrimidine tract binding; ISS:FlyBase. DR GO; GO:0000900; F:translation repressor activity, nucleic acid binding; IMP:FlyBase. DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase. DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase. DR GO; GO:0007319; P:negative regulation of oskar mRNA translation; IMP:FlyBase. DR GO; GO:0000398; P:nuclear mRNA splicing, via spliceosome; ISS:FlyBase. DR GO; GO:0008103; P:oocyte microtubule cytoskeleton polarization; IMP:FlyBase. DR GO; GO:0007291; P:sperm individualization; IMP:FlyBase. DR Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 3. DR InterPro; IPR006536; HnRNP-L_PTB. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait. DR InterPro; IPR000504; RRM_dom. DR SMART; SM00360; RRM; 3. DR TIGRFAMs; TIGR01649; HnRNP-L_PTB; 1. DR PROSITE; PS50102; RRM; 3. PE 4: Predicted; KW Complete proteome; Reference proteome. SQ SEQUENCE 493 AA; 53384 MW; 1191274C89562CF0 CRC64; MADEISATSM VSCYTVTPPQ MRGRMVYVQF SNHRELKTDQ GHNNSTAHSD YSVQSPASGS PLPLSAAANA TSNNANSSSD SNSAMGILQN TSAVNAGGNT NAAGGPNTVL RVIVESLMYP VSLDILHQIF QRYGKVLKIV TFTKNNSFQA LIQYPDANSA QHAKSLLDGQ NIYNGCCTLR IDNSKLTALN VKYNNDKSRD FTNPALPPGE PGVDIMPTAG GLMNTNDLLL IAARQRPSLS GDKIVNGLGA PGVLPPFALG LGTPLTGGYN NALPNLAAFS LANSGALQTT APAMRGYSNV LLVSNLNEEM VTPDALFTLF GVYGDVQRVK ILYNKKDSAL IQMAEPQQAY LAMSHLDKLR LWGKPIRVMA SKHQAVQLPK EGQPDAGLTR DYSQNPLHRF KKPGSKNYQN IYPPSATLHL SNIPSSCSED DIKEAFTSNS FEVKAFKFFP KDRKMALLQL LSVEEAVLAL IKMHNHQLSE SNHLRVSFSK SNI //