ID E1JIN6_DROME Unreviewed; 2716 AA. AC E1JIN6; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 19-JAN-2022, entry version 97. DE SubName: Full=Osa, isoform D {ECO:0000313|EMBL:ACZ94935.1}; GN Name=osa {ECO:0000313|EMBL:ACZ94935.1, GN ECO:0000313|FlyBase:FBgn0261885}; GN Synonyms=4H {ECO:0000313|EMBL:ACZ94935.1}, anon-WO0118547.314 GN {ECO:0000313|EMBL:ACZ94935.1}, anon-WO0172774.126 GN {ECO:0000313|EMBL:ACZ94935.1}, C819 {ECO:0000313|EMBL:ACZ94935.1}, GN Dmel\CG7467 {ECO:0000313|EMBL:ACZ94935.1}, E(E2F)3C GN {ECO:0000313|EMBL:ACZ94935.1}, eld {ECO:0000313|EMBL:ACZ94935.1}, GN en(lz)4F {ECO:0000313|EMBL:ACZ94935.1}, eyelid GN {ECO:0000313|EMBL:ACZ94935.1}, l(3)00090 GN {ECO:0000313|EMBL:ACZ94935.1}, l(3)04539 GN {ECO:0000313|EMBL:ACZ94935.1}, l(3)j9C3 {ECO:0000313|EMBL:ACZ94935.1}, GN OSA {ECO:0000313|EMBL:ACZ94935.1}, Osa {ECO:0000313|EMBL:ACZ94935.1}, GN p300 {ECO:0000313|EMBL:ACZ94935.1}; GN ORFNames=CG7467 {ECO:0000313|EMBL:ACZ94935.1, GN ECO:0000313|FlyBase:FBgn0261885}, Dmel_CG7467 GN {ECO:0000313|EMBL:ACZ94935.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ACZ94935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ACZ94935.1; -; Genomic_DNA. DR RefSeq; NP_001163639.1; NM_001170168.2. DR RefSeq; NP_524392.2; NM_079668.3. DR SMR; E1JIN6; -. DR PRIDE; E1JIN6; -. DR EnsemblMetazoa; FBtr0089581; FBpp0088543; FBgn0261885. DR EnsemblMetazoa; FBtr0301487; FBpp0290702; FBgn0261885. DR GeneID; 42130; -. DR KEGG; dme:Dmel_CG7467; -. DR CTD; 42130; -. DR FlyBase; FBgn0261885; osa. DR VEuPathDB; VectorBase:FBgn0261885; -. DR OMA; WAQMNAG; -. DR OrthoDB; 256110at2759; -. DR PhylomeDB; E1JIN6; -. DR BioGRID-ORCS; 42130; 1 hit in 3 CRISPR screens. DR ChiTaRS; osa; fly. DR GenomeRNAi; 42130; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0261885; Expressed in eye disc (Drosophila) and 39 other tissues. DR ExpressionAtlas; E1JIN6; baseline and differential. DR GO; GO:0035060; C:brahma complex; IEA:InterPro. DR GO; GO:0016514; C:SWI/SNF complex; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro. DR Gene3D; 1.10.150.60; -; 1. DR InterPro; IPR001606; ARID_dom. DR InterPro; IPR036431; ARID_dom_sf. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR021906; BAF250/Osa. DR InterPro; IPR033388; BAF250_C. DR PANTHER; PTHR12656; PTHR12656; 2. DR Pfam; PF01388; ARID; 1. DR Pfam; PF12031; BAF250_C; 1. DR SMART; SM00501; BRIGHT; 1. DR SUPFAM; SSF46774; SSF46774; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS51011; ARID; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|PeptideAtlas:E1JIN6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 1000..1091 FT /note="ARID" FT /evidence="ECO:0000259|PROSITE:PS51011" FT REGION 1..969 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1108..1766 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1914..1936 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2045..2124 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2520..2617 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2684..2716 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1852..1872 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1..20 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 45..66 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 67..86 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 95..109 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 171..211 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 233..251 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 259..293 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 294..348 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 350..386 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 410..470 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 471..503 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 511..549 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 552..570 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 571..593 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 594..623 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 651..684 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 749..764 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 803..826 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 827..846 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 857..872 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 881..932 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1126..1146 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1269..1285 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1286..1301 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1308..1325 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1343..1359 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1360..1383 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1425..1442 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1504..1524 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1531..1546 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1590..1604 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1635..1656 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1914..1930 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2045..2076 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2077..2093 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2540..2617 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2716 AA; 284064 MW; EFAE76CB51C7C675 CRC64; MNEKIKSPQT QQQQQGGAPA PAATPPSAGA APGAATPPTS GPPTPNNNSN NGSDPSIQQQ QQNVAPHPYG APPPPGSGPG GPPGPDPAAV MHYHHLHQQQ QQHPPPPHMQ QQQHHGGPAP PPPGGAPEHA PGVKEEYTHL PPPHPHPAYG RYHADPNMDP YRYGQPLPGG KPPQQQQPHP QQQPPQQPGP GGSPNRPPQQ RYIPGQPPQG PTPTLNSLLQ SSNPPPPPQH RYANTYDPQQ AAASAAAAAA AQQQQAGGPP PPGHGPPPPQ HQPSPYGGQQ GGWAPPPRPY SPQLGPSQQY RTPPPTNTSR GQSPYPPAHG QNSGSYPSSP QQQQQQQQQQ QQQAGQQPGG PVPGGPPPGT GQQPPQQNTP PTSQYSPYPQ RYPTPPGLPA GGSNHRTAYS THQYPEPNRP WPGGSSPSPG SGHPLPPASP HHVPPLQQQP PPPPHVSAGG PPPSSSPGHA PSPSPQPSQA SPSPHQELIG QNSNDSSSGG AHSGMGSGPP GTPNPQQVMR PTPSPTGSSG SRSMSPAVAQ NHPISRPASN QSSSGGPMQQ PPVGAGGPPP MPPHPGMPGG PPQQQQSQQQ QASNSASSAS NSPQQTPPPA PPPNQGMNNM ATPPPPPQGA AGGGYPMPPH MHGGYKMGGP GQSPGAQGYP PQQPQQYPPG NYPPRPQYPP GAYATGPPPP PTSQAGAGGA NSMPSGAQAG GYPGRGMPNH TGQYPPYQWV PPSPQQTVPG GAPGGAMVGN HVQGKGTPPP PVVGGPPPPQ GSGSPRPLNY LKQHLQHKGG YGGSPTPPQG PQGYGNGPTG MHPGMPMGPP HHMGPPHGPT NMGPPTSTPP QSQMLQGGQP QGQGASGGPE SGGPEHISQD NGISSSGPTG AAGMHAVTSV VTTGPDGTSM DEVSQQSTLS NASAASGEDP QCTTPKSRKN DPYSQSHLAP PSTSPHPVVM HPGGGPGEEY DMSSPPNWPR PAGSPQVFNH VPVPQEPFRS TITTTKKSDS LCKLYEMDDN PDRRGWLDKL RAFMEERRTP ITACPTISKQ PLDLYRLYIY VKERGGFVEV TKSKTWKDIA GLLGIGASSS AAYTLRKHYT KNLLTFECHF DRGDIDPLPI IQQVEAGSKK KTAKAASVPS PGGGHLDAGT TNSTGSSNSQ DSFPAPPGSA PNAAIDGYPG YPGGSPYPVA SGPQPDYATA GQMQRPPSQN NPQTPHPGAA AAVAAGDNIS VSNPFEDPIA AGGGPGSGTG PGPGQGPGPG AASGGAGAVG AVGGGPQPHP PPPHSPHTAA QQAAGQHQQQ HPQHQHPGLP GPPPPQQQQG QQGQQPPPSV GGGPPPAPQQ HGPGQVPPSP QQHVRPAAGA PYPPGGSGYP TPVSRTPGSP YPSQPGAYGQ YGSSDQYNAT GPPGQPFGQG PGQYPPQNRN MYPPYGPEGE APPTGANQYG PYGSRPYSQP PPGGPQPPTQ TVAGGPPAGG APGAPPSSAY PTGRPSQQDY YQPPPDQSPQ PRRHPDFIKD SQPYPGYNAR PQIYGAWQSG TQQYRPQYPS SPAPQNWGGA PPRGAAPPPG APHGPPIQQP AGVAQWDQHR YPPQQGPPPP PQQQQQPQQQ QQQPPYQQVA GPPGQQPPQA PPQWAQMNPG QTAQSGIAPP GSPLRPPSGP GQQNRMPGMP AQQQQSQQQG GVPQPPPQQA SHGGVPSPGL PQVGPGGMVK PPYAMPPPPS QGVGQQVGQG PPGGMMSQKP PPMPGQAMQQ QPLQQQPPSH QHPHPHQHPQ HQHPHQMPPN QTAPGGYGPP GMPGGGAQLV KKELIFPHDS VESTTPVLYR RKRLMKADVC PVDPWRIFMA MRSGLLTECT WALDVLNVLL FDDSTVQFFG ISNLPGLLTL LLEHFQKNLA EMFDERENEE QSALLAEDAD DDADSGTVMC EKLRTSGRQP RCVRSISSYN RRRHYENMDR SGKDGAGNGS DSEDADEGID LGQVRVQPNP EERSLLLSFT PNYTMVTRKG VPVRIQPAEN DIFVDERQKA WDIDTNRLYE QLEPVGSDAW TYGFTEPDPL DGIIDVFKSE IVNIPFARYI RSDKKGRKRT ELASSSRKPE IKTEENSTEE QTFNKKRRLV SGGSSSSGAH AEGKKSKLTS EEFAQPNAEV KKEPGTADSD CRPVDMDIEA PQQRLTNGVA PCSSTPAIFD PRTTAKDEAR VLQRRRDSSF EDECYTRDEA SLHLVSESQD SLARRCIALS NIFRNLTFVP GNETVLAKST RFLAVLGRLL LLNHEHLRRT PKTRNYDREE DTDFSDSCSS LQGEREWWWD YLITIRENML VAMANIAGHL ELSRYDELIA RPLIDGLLHW AVCPSAHGQD PFPSCGPNSV LSPQRLALEA LCKLCVTDAN VDLVIATPPF SRLEKLCAVL TRHLCRNEDQ VLREFSVNLL HYLAAADSAM ARTVALQSPC ISYLVAFIEQ AEQTALGVAN QHGINYLREN PDSMGTSLDM LRRAAGTLLH LAKHPDNRSL FMQQEQRLLG LVMSHILDQQ VALIISRVLY QVSRGTGPIH SVEFRLLQQR QQQQLRPGPA GKQAASAGGS ATVKAETAST ETSSTEAKPA PAATTAVVND ENSNSSQQLP PAATFNDVSN SSTNSNSCGT ASSNQTNNST TNSSHSSSAI SSQSAITVAA PSAAATGAGS ATAAAIASDQ QQVSKVAAAA AAAAALSNAS AAAAAAAAAA AASVGPPTSS SVSAGAAVAQ PAAPPPTNAG TTTAVA //