ID E1JGN0_DROME Unreviewed; 1141 AA. AC E1JGN0; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 03-OCT-2012, entry version 19. DE SubName: Full=Par-1, isoform P; DE EC=2.7.11.-; DE EC=2.7.11.26; GN Name=par-1; ORFNames=Dmel_CG8201; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426070; PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426071; PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426065; PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL (er) Genome Biol. 3 (12), RESEARCH0079 (2002). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; ACZ94480.1; -; Genomic_DNA. DR RefSeq; NP_001163208.1; NM_001169737.1. DR UniGene; Dm.2222; -. DR ProteinModelPortal; E1JGN0; -. DR SMR; E1JGN0; 477-793, 1042-1141. DR EnsemblMetazoa; FBtr0301503; FBpp0290718; FBgn0260934. DR GeneID; 2768852; -. DR KEGG; dme:Dmel_CG8201; -. DR CTD; 2768852; -. DR FlyBase; FBgn0260934; par-1. DR GeneTree; ENSGT00670000097510; -. DR KO; K05960; -. DR GenomeRNAi; 2768852; -. DR NextBio; 848305; -. DR Bgee; E1JGN0; -. DR GO; GO:0016323; C:basolateral plasma membrane; IDA:FlyBase. DR GO; GO:0005938; C:cell cortex; IDA:FlyBase. DR GO; GO:0045169; C:fusome; IDA:FlyBase. DR GO; GO:0045172; C:germline ring canal; IDA:FlyBase. DR GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase. DR GO; GO:0061174; C:type I terminal button; IDA:FlyBase. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:FlyBase. DR GO; GO:0050321; F:tau-protein kinase activity; IDA:FlyBase. DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase. DR GO; GO:0019730; P:antimicrobial humoral response; IMP:FlyBase. DR GO; GO:0030709; P:border follicle cell delamination; IMP:FlyBase. DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase. DR GO; GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase. DR GO; GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase. DR GO; GO:0045185; P:maintenance of protein location; TAS:FlyBase. DR GO; GO:0090176; P:microtubule cytoskeleton organization involved in establishment of planar polarity; IMP:FlyBase. DR GO; GO:0016325; P:oocyte microtubule cytoskeleton organization; IMP:FlyBase. DR GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IMP:FlyBase. DR GO; GO:0045451; P:pole plasm oskar mRNA localization; TAS:FlyBase. DR GO; GO:0007318; P:pole plasm protein localization; IMP:FlyBase. DR GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase. DR GO; GO:0007317; P:regulation of pole plasm oskar mRNA localization; IMP:FlyBase. DR GO; GO:0030111; P:regulation of Wnt receptor signaling pathway; TAS:FlyBase. DR GO; GO:0051124; P:synaptic growth at neuromuscular junction; IMP:FlyBase. DR Gene3D; G3DSA:3.30.310.80; Kinase-assoc_KA1; 1. DR InterPro; IPR001772; Kinase-assoc_KA1. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_cat_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk. DR Pfam; PF02149; KA1; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SMART; SM00165; UBA; 1. DR SUPFAM; SSF103243; Kinase-assoc_KA1; 1. DR SUPFAM; SSF56112; Kinase_like; 1. DR PROSITE; PS50032; KA1; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR PROSITE; PS50030; UBA; 1. PE 4: Predicted; KW ATP-binding; Complete proteome; Nucleotide-binding; KW Reference proteome; Transferase. SQ SEQUENCE 1141 AA; 124626 MW; 0798140BE6A3764F CRC64; MEATTTTTPD LNRGDATRKS VRLYAARKGA APAPPKLSVA PSSNQNSNHS SNNNNSSSNL PETEKEMELR QTHLANKDLD GATEDDSIVE LRRRDAQATP LPRIAVSALP TLQPHPTPKE RQKPPMPRLL STEDDAGVSF ALGSIEKHIH NVEESFKQQQ QNQQSQSSMD VMKLEIKRKQ SKRYGETENL LRPGISDMSS ENDFQYLGGR RAGELDDSNE LMLSEFQRGS DGRNSIGAYS KNSAAAANGA NAVKAKLART ASDTKNNDTV LAMRATFKQK QHLQDEKQPA VWRPAGTGPT PAARSSSSTT STSGSASRGG SSSSVVDGVA PSKLTATTIS ASKRREENLR QFEALLAQKS SHRHGASGAS GTGSNAASSK RRSDRPIVAP IPPYNSSRAE HVTSSTRHSV DPRSHSGHES RSGTASTHPP VGHHPTSRVP SVVANRSNVY SNNAAQGSPN MQMRSSAPMR WRATEEHIGK YKLIKTIGKG NFAKVKLAKH LPTGKEVAIK IIDKTQLNPG SLQKLFREVR IMKMLDHPNI VKLFQVIETE KTLYLIMEYA SGGEVFDYLV LHGRMKEKEA RVKFRQIVSA VQYCHQKRII HRDLKAENLL LDSELNIKIA DFGFSNEFTP GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD VWSLGVILYT LVSGSLPFDG STLRELRERV LRGKYRIPFY MSTDCENLLR KFLVLNPAKR ASLETIMGDK WMNMGFEEDE LKPYIEPKAD LADPKRIGKT EALVAMGYNR SEIEASLSQV RYDDVFATYL LLGRKSTDPE SDGSRSGSSL SLRNISGNDA GANAGSASVQ SPTHRGVHRS ISASSTKPSR RASSGAETLR VGPTNAAATV AAATGAVGAV NPSNNYNAAG SAADRASVGS NFKRQNTIDS ATIKENTARL AAQNQRPASA TQKMLTTADT TLNSPAKPRT ATKYDPTNGN RTVSGTSGII PRRSTTLYEK TSSTEKTNVI PAETKARNNT ALEYSGTSGA SGDSSHPGRM SFFSKLSSRF SKRPTIADEA AKPRVLRFTW SMKTTSPLMP DQIMQKIREV LDQNNCDYEQ RERFVLWCVH GDPNTDSLVQ WEIEVCKLPR LSLNGVRFKR ISGTSIGFKN IASRIAFDLK L //