ID E1BM22_BOVIN Unreviewed; 126 AA. AC E1BM22; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 08-NOV-2023, entry version 87. DE RecName: Full=Histone H2A/H2B/H3 domain-containing protein {ECO:0000259|Pfam:PF00125}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000046113.3, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000046113.3, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113.3, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000046113.3} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113.3}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the histone H2B family. CC {ECO:0000256|ARBA:ARBA00006846}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_010810615.1; XM_010812313.2. DR RefSeq; XP_010821041.1; XM_010822739.2. DR AlphaFoldDB; E1BM22; -. DR SMR; E1BM22; -. DR STRING; 9913.ENSBTAP00000046113; -. DR PaxDb; 9913-ENSBTAP00000046113; -. DR Ensembl; ENSBTAT00000049181.4; ENSBTAP00000046113.3; ENSBTAG00000054100.1. DR GeneID; 100300167; -. DR KEGG; bta:100300167; -. DR VEuPathDB; HostDB:ENSBTAG00000054100; -. DR eggNOG; KOG1744; Eukaryota. DR GeneTree; ENSGT01090000259992; -. DR HOGENOM; CLU_075666_2_1_1; -. DR InParanoid; E1BM22; -. DR OrthoDB; 4993770at2759; -. DR TreeFam; TF300212; -. DR Reactome; R-BTA-110330; Recognition and association of DNA glycosylase with site containing an affected purine. DR Reactome; R-BTA-110331; Cleavage of the damaged purine. DR Reactome; R-BTA-171306; Packaging Of Telomere Ends. DR Reactome; R-BTA-201722; Formation of the beta-catenin:TCF transactivating complex. DR Reactome; R-BTA-212300; PRC2 methylates histones and DNA. DR Reactome; R-BTA-2299718; Condensation of Prophase Chromosomes. DR Reactome; R-BTA-2559580; Oxidative Stress Induced Senescence. DR Reactome; R-BTA-2559582; Senescence-Associated Secretory Phenotype (SASP). DR Reactome; R-BTA-2559586; DNA Damage/Telomere Stress Induced Senescence. DR Reactome; R-BTA-3214815; HDACs deacetylate histones. DR Reactome; R-BTA-3214847; HATs acetylate histones. DR Reactome; R-BTA-427359; SIRT1 negatively regulates rRNA expression. DR Reactome; R-BTA-427413; NoRC negatively regulates rRNA expression. DR Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression. DR Reactome; R-BTA-5578749; Transcriptional regulation by small RNAs. DR Reactome; R-BTA-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. DR Reactome; R-BTA-5689880; Ub-specific processing proteases. DR Reactome; R-BTA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. DR Reactome; R-BTA-5693571; Nonhomologous End-Joining (NHEJ). DR Reactome; R-BTA-5693607; Processing of DNA double-strand break ends. DR Reactome; R-BTA-606279; Deposition of new CENPA-containing nucleosomes at the centromere. DR Reactome; R-BTA-68616; Assembly of the ORC complex at the origin of replication. DR Reactome; R-BTA-69473; G2/M DNA damage checkpoint. DR Reactome; R-BTA-73728; RNA Polymerase I Promoter Opening. DR Reactome; R-BTA-73772; RNA Polymerase I Promoter Escape. DR Reactome; R-BTA-8866654; E3 ubiquitin ligases ubiquitinate target proteins. DR Reactome; R-BTA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function. DR Reactome; R-BTA-9018519; Estrogen-dependent gene expression. DR Reactome; R-BTA-9670095; Inhibition of DNA recombination at telomere. DR Proteomes; UP000009136; Chromosome 15. DR Bgee; ENSBTAG00000054100; Expressed in gall bladder and 8 other tissues. DR GO; GO:0000786; C:nucleosome; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro. DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro. DR Gene3D; 1.10.20.10; Histone, subunit A; 1. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_H2A/H2B/H3. DR InterPro; IPR000558; Histone_H2B. DR PANTHER; PTHR23428; HISTONE H2B; 1. DR PANTHER; PTHR23428:SF250; HISTONE H2B TYPE 1-D; 1. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00621; HISTONEH2B. DR SMART; SM00427; H2B; 1. DR SUPFAM; SSF47113; Histone-fold; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 9..101 FT /note="Histone H2A/H2B/H3" FT /evidence="ECO:0000259|Pfam:PF00125" FT REGION 1..35 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 17..31 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 126 AA; 13953 MW; BCBE6661FD781FC3 CRC64; MPELAKSSPA PKKGSKKSVT KAQKKDGKKC KHSRKESYSV YVYKVLKQVH PDTNISSKAI GIMNSFINDI FEHITGEALR LAHYNKRSTI TSREIQTAVR LLLPGELVKH TVSKGTKAVT KSTSSK //