ID E1BM22_BOVIN Unreviewed; 126 AA. AC E1BM22; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 03-AUG-2022, entry version 80. DE RecName: Full=Histone domain-containing protein {ECO:0000259|Pfam:PF00125}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000046113, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000046113} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000046113, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the histone H2B family. CC {ECO:0000256|ARBA:ARBA00006846}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_010810615.1; XM_010812313.2. DR RefSeq; XP_010821041.1; XM_010822739.2. DR SMR; E1BM22; -. DR STRING; 9913.ENSBTAP00000046113; -. DR PaxDb; E1BM22; -. DR Ensembl; ENSBTAT00000049181.4; ENSBTAP00000046113.3; ENSBTAG00000054100.1. DR GeneID; 100300167; -. DR KEGG; bta:100300167; -. DR VEuPathDB; HostDB:ENSBTAG00000054100; -. DR eggNOG; KOG1744; Eukaryota. DR GeneTree; ENSGT01050000244832; -. DR HOGENOM; CLU_075666_2_1_1; -. DR InParanoid; E1BM22; -. DR OrthoDB; 1536672at2759; -. DR TreeFam; TF300212; -. DR Reactome; R-BTA-110330; Recognition and association of DNA glycosylase with site containing an affected purine. DR Reactome; R-BTA-110331; Cleavage of the damaged purine. DR Reactome; R-BTA-201722; Formation of the beta-catenin:TCF transactivating complex. DR Reactome; R-BTA-212300; PRC2 methylates histones and DNA. DR Reactome; R-BTA-2299718; Condensation of Prophase Chromosomes. DR Reactome; R-BTA-2559580; Oxidative Stress Induced Senescence. DR Reactome; R-BTA-3214815; HDACs deacetylate histones. DR Reactome; R-BTA-3214847; HATs acetylate histones. DR Reactome; R-BTA-427359; SIRT1 negatively regulates rRNA expression. DR Reactome; R-BTA-427413; NoRC negatively regulates rRNA expression. DR Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression. DR Reactome; R-BTA-5689880; Ub-specific processing proteases. DR Reactome; R-BTA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. DR Reactome; R-BTA-606279; Deposition of new CENPA-containing nucleosomes at the centromere. DR Reactome; R-BTA-73728; RNA Polymerase I Promoter Opening. DR Reactome; R-BTA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function. DR Reactome; R-BTA-9018519; Estrogen-dependent gene expression. DR Reactome; R-BTA-9670095; Inhibition of DNA recombination at telomere. DR Proteomes; UP000009136; Chromosome 15. DR Bgee; ENSBTAG00000054100; Expressed in gall bladder and 8 other tissues. DR GO; GO:0000786; C:nucleosome; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro. DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro. DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central. DR Gene3D; 1.10.20.10; -; 1. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_H2A/H2B/H3. DR InterPro; IPR000558; Histone_H2B. DR PANTHER; PTHR23428; PTHR23428; 1. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00621; HISTONEH2B. DR SMART; SM00427; H2B; 1. DR SUPFAM; SSF47113; SSF47113; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 7..101 FT /note="Histone" FT /evidence="ECO:0000259|Pfam:PF00125" FT REGION 1..35 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 17..31 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 126 AA; 13953 MW; BCBE6661FD781FC3 CRC64; MPELAKSSPA PKKGSKKSVT KAQKKDGKKC KHSRKESYSV YVYKVLKQVH PDTNISSKAI GIMNSFINDI FEHITGEALR LAHYNKRSTI TSREIQTAVR LLLPGELVKH TVSKGTKAVT KSTSSK //