ID E1BM22_BOVIN Unreviewed; 126 AA. AC E1BM22; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 31-JUL-2019, entry version 65. DE RecName: Full=Histone domain-containing protein {ECO:0000259|Pfam:PF00125}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000046113, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000046113, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000046113} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SUBUNIT: The nucleosome is a histone octamer containing two CC molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 CC heterotetramer and two H2A-H2B heterodimers. CC {ECO:0000256|SAAS:SAAS01176640}. CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS01176634}. CC Nucleus {ECO:0000256|SAAS:SAAS01185060}. CC -!- SIMILARITY: Belongs to the histone H2B family. CC {ECO:0000256|SAAS:SAAS00689654}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_010810615.1; XM_010812313.2. DR RefSeq; XP_010821041.1; XM_010822739.2. DR SMR; E1BM22; -. DR STRING; 9913.ENSBTAP00000046113; -. DR PaxDb; E1BM22; -. DR Ensembl; ENSBTAT00000049181; ENSBTAP00000046113; ENSBTAG00000054100. DR GeneID; 100300167; -. DR KEGG; bta:100300167; -. DR eggNOG; KOG1744; Eukaryota. DR eggNOG; ENOG4111NV5; LUCA. DR GeneTree; ENSGT00950000182677; -. DR InParanoid; E1BM22; -. DR KO; K11252; -. DR OrthoDB; 1536672at2759; -. DR TreeFam; TF300212; -. DR Reactome; R-BTA-110330; Recognition and association of DNA glycosylase with site containing an affected purine. DR Reactome; R-BTA-110331; Cleavage of the damaged purine. DR Reactome; R-BTA-171306; Packaging Of Telomere Ends. DR Reactome; R-BTA-201722; Formation of the beta-catenin:TCF transactivating complex. DR Reactome; R-BTA-212300; PRC2 methylates histones and DNA. DR Reactome; R-BTA-2299718; Condensation of Prophase Chromosomes. DR Reactome; R-BTA-2559580; Oxidative Stress Induced Senescence. DR Reactome; R-BTA-2559582; Senescence-Associated Secretory Phenotype (SASP). DR Reactome; R-BTA-2559586; DNA Damage/Telomere Stress Induced Senescence. DR Reactome; R-BTA-427359; SIRT1 negatively regulates rRNA expression. DR Reactome; R-BTA-427413; NoRC negatively regulates rRNA expression. DR Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression. DR Reactome; R-BTA-5578749; Transcriptional regulation by small RNAs. DR Reactome; R-BTA-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. DR Reactome; R-BTA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. DR Reactome; R-BTA-5693571; Nonhomologous End-Joining (NHEJ). DR Reactome; R-BTA-606279; Deposition of new CENPA-containing nucleosomes at the centromere. DR Reactome; R-BTA-69473; G2/M DNA damage checkpoint. DR Reactome; R-BTA-73728; RNA Polymerase I Promoter Opening. DR Reactome; R-BTA-73772; RNA Polymerase I Promoter Escape. DR Reactome; R-BTA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function. DR Reactome; R-BTA-9018519; Estrogen-dependent gene expression. DR Proteomes; UP000009136; Chromosome 15. DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro. DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central. DR Gene3D; 1.10.20.10; -; 1. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_H2A/H2B/H3. DR InterPro; IPR000558; Histone_H2B. DR PANTHER; PTHR23428; PTHR23428; 1. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00621; HISTONEH2B. DR SMART; SM00427; H2B; 1. DR SUPFAM; SSF47113; SSF47113; 1. PE 3: Inferred from homology; KW Chromosome {ECO:0000256|SAAS:SAAS01176635}; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW DNA-binding {ECO:0000256|SAAS:SAAS01185055}; KW Nucleosome core {ECO:0000256|SAAS:SAAS01185057}; KW Nucleus {ECO:0000256|SAAS:SAAS01185059}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 7 101 Histone. {ECO:0000259|Pfam:PF00125}. FT REGION 1 35 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 17 31 Basic. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 126 AA; 13953 MW; BCBE6661FD781FC3 CRC64; MPELAKSSPA PKKGSKKSVT KAQKKDGKKC KHSRKESYSV YVYKVLKQVH PDTNISSKAI GIMNSFINDI FEHITGEALR LAHYNKRSTI TSREIQTAVR LLLPGELVKH TVSKGTKAVT KSTSSK //