ID E1BM22_BOVIN Unreviewed; 126 AA. AC E1BM22; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 08-JUN-2016, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000046113}; GN Name=LOC100300167 {ECO:0000313|Ensembl:ENSBTAP00000046113}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000046113, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000046113, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000046113} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046113}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and CC compact DNA into chromatin, limiting DNA accessibility to the CC cellular machineries which require DNA as a template. Histones CC thereby play a central role in transcription regulation, DNA CC repair, DNA replication and chromosomal stability. DNA CC accessibility is regulated via a complex set of post-translational CC modifications of histones, also called histone code, and CC nucleosome remodeling. {ECO:0000256|SAAS:SAAS00377016}. CC -!- SUBUNIT: The nucleosome is a histone octamer containing two CC molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 CC heterotetramer and two H2A-H2B heterodimers. CC {ECO:0000256|SAAS:SAAS00566009}. CC -!- SUBUNIT: The nucleosome is a histone octamer containing two CC molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 CC heterotetramer and two H2A-H2B heterodimers. The octamer wraps CC approximately 147 bp of DNA. {ECO:0000256|SAAS:SAAS00408289}. CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00565666}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00566189}. CC -!- SIMILARITY: Belongs to the histone H2B family. CC {ECO:0000256|SAAS:SAAS00565685}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000046113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DAAA02040087; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_010810615.1; XM_010812313.2. DR RefSeq; XP_010821041.1; XM_010822739.2. DR STRING; 9913.ENSBTAP00000046113; -. DR PaxDb; E1BM22; -. DR PRIDE; E1BM22; -. DR Ensembl; ENSBTAT00000049181; ENSBTAP00000046113; ENSBTAG00000034724. DR GeneID; 100300167; -. DR KEGG; bta:100300167; -. DR eggNOG; KOG1744; Eukaryota. DR eggNOG; ENOG4111NV5; LUCA. DR GeneTree; ENSGT00840000131085; -. DR InParanoid; E1BM22; -. DR OrthoDB; EOG72VH8J; -. DR TreeFam; TF300212; -. DR Proteomes; UP000009136; Chromosome 15. DR GO; GO:0000788; C:nuclear nucleosome; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IBA:GO_Central. DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central. DR Gene3D; 1.10.20.10; -; 1. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_H2A/H2B/H3. DR InterPro; IPR000558; Histone_H2B. DR PANTHER; PTHR23428; PTHR23428; 1. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00621; HISTONEH2B. DR SMART; SM00427; H2B; 1. DR SUPFAM; SSF47113; SSF47113; 1. PE 3: Inferred from homology; KW Chromosome {ECO:0000256|SAAS:SAAS00565869}; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW DNA-binding {ECO:0000256|SAAS:SAAS00565767}; KW Nucleosome core {ECO:0000256|SAAS:SAAS00454795}; KW Nucleus {ECO:0000256|SAAS:SAAS00565977}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 7 101 Histone. {ECO:0000259|Pfam:PF00125}. SQ SEQUENCE 126 AA; 13953 MW; BCBE6661FD781FC3 CRC64; MPELAKSSPA PKKGSKKSVT KAQKKDGKKC KHSRKESYSV YVYKVLKQVH PDTNISSKAI GIMNSFINDI FEHITGEALR LAHYNKRSTI TSREIQTAVR LLLPGELVKH TVSKGTKAVT KSTSSK //