ID E0CXK7_MOUSE Unreviewed; 296 AA. AC E0CXK7; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 2. DT 28-JUN-2023, entry version 80. DE SubName: Full=Homeobox protein Hox-A13 {ECO:0000313|Ensembl:ENSMUSP00000125221}; GN Name=Hoxa13 {ECO:0000313|Ensembl:ENSMUSP00000125221, GN ECO:0000313|MGI:MGI:96173}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000125221, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000125221, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125221, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000125221} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125221}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. CC {ECO:0000256|ARBA:ARBA00006317}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC015583; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FQ828346; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E0CXK7; -. DR SMR; E0CXK7; -. DR ProteomicsDB; 347308; -. DR Antibodypedia; 12410; 162 antibodies from 26 providers. DR Ensembl; ENSMUST00000147595; ENSMUSP00000125221; ENSMUSG00000038203. DR AGR; MGI:96173; -. DR MGI; MGI:96173; Hoxa13. DR VEuPathDB; HostDB:ENSMUSG00000038203; -. DR HOGENOM; CLU_059940_2_1_1; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000038203; Expressed in phalanx and 96 other tissues. DR ExpressionAtlas; E0CXK7; baseline and differential. DR GO; GO:0005694; C:chromosome; IEA:Ensembl. DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl. DR GO; GO:0048619; P:embryonic hindgut morphogenesis; IEA:Ensembl. DR GO; GO:0030850; P:prostate gland development; IEA:Ensembl. DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR022067; HoxA13_N. DR PANTHER; PTHR45804:SF3; HOMEOBOX PROTEIN HOX-A13; 1. DR PANTHER; PTHR45804; SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF12284; HoxA13_N; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 3: Inferred from homology; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 228..288 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 230..289 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" SQ SEQUENCE 296 AA; 31136 MW; 0F4E5FF4140D85B7 CRC64; MAHPAPLAPG AAAAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA AAAFADKYMD TAGPAAEEFS SRAKEFAFYH QGYAAGPYHH HQPVPGYLDM PVVPGLGGPG ESRHEPLGLP MESYQPWALP NGWNGQMYCP KEQTQPPHLW KSTLPDVVSH PSDASSYRRG RKKRVPYTKV QLKELEREYA TNKFITKDKR RRISATTNLS ERQVTIWFQN RRVKEKKVIN KLKTTS //