ID E0CXK7_MOUSE Unreviewed; 296 AA. AC E0CXK7; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 2. DT 19-JAN-2022, entry version 74. DE SubName: Full=Homeobox protein Hox-A13 {ECO:0000313|Ensembl:ENSMUSP00000125221}; GN Name=Hoxa13 {ECO:0000313|Ensembl:ENSMUSP00000125221, GN ECO:0000313|MGI:MGI:96173}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000125221, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000125221, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125221, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000125221} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125221}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. CC {ECO:0000256|ARBA:ARBA00006317}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC015583; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FQ828346; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; E0CXK7; -. DR ProteomicsDB; 347308; -. DR Antibodypedia; 12410; 149 antibodies from 25 providers. DR Ensembl; ENSMUST00000147595; ENSMUSP00000125221; ENSMUSG00000038203. DR MGI; MGI:96173; Hoxa13. DR VEuPathDB; HostDB:ENSMUSG00000038203; -. DR HOGENOM; CLU_059940_2_1_1; -. DR OMA; KNMEGFP; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000038203; Expressed in undifferentiated genital tubercle and 123 other tissues. DR ExpressionAtlas; E0CXK7; baseline and differential. DR GO; GO:0005694; C:chromosome; IEA:Ensembl. DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl. DR GO; GO:0048619; P:embryonic hindgut morphogenesis; IEA:Ensembl. DR GO; GO:0030850; P:prostate gland development; IEA:Ensembl. DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR022067; HoxA13_N. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF12284; HoxA13_N; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 3: Inferred from homology; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 228..288 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 230..289 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" SQ SEQUENCE 296 AA; 31136 MW; 0F4E5FF4140D85B7 CRC64; MAHPAPLAPG AAAAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA AAAFADKYMD TAGPAAEEFS SRAKEFAFYH QGYAAGPYHH HQPVPGYLDM PVVPGLGGPG ESRHEPLGLP MESYQPWALP NGWNGQMYCP KEQTQPPHLW KSTLPDVVSH PSDASSYRRG RKKRVPYTKV QLKELEREYA TNKFITKDKR RRISATTNLS ERQVTIWFQN RRVKEKKVIN KLKTTS //