ID   D9ZYG9_9INFA            Unreviewed;       757 AA.
AC   D9ZYG9;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   18-APR-2012, entry version 8.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit;
DE            EC=2.7.7.48;
GN   Name=PB1;
OS   Influenza A virus (A/chicken/Xinjiang/17/2005(H5N1)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=762400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/chicken/Xinjiang/17/2005;
RX   PubMed=20538856; DOI=10.1128/JVI.00413-10;
RA   Li Y., Shi J., Zhong G., Deng G., Tian G., Ge J., Zeng X., Song J.,
RA   Zhao D., Liu L., Jiang Y., Guan Y., Bu Z., Chen H.;
RT   "Continued Evolution of H5N1 Influenza Viruses in Wild Birds, Domestic
RT   Poultry, and Humans in China from 2004 to 2009.";
RL   J. Virol. 84:8389-8397(2010).
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1).
CC   -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1
CC       family.
CC   -!- SIMILARITY: Contains 1 RdRp catalytic domain.
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DR   EMBL; HM172399; ADG59471.1; -; Viral_cRNA.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host RNA polymerase II by virus;
KW   Nucleotide-binding; Nucleotidyltransferase; RNA replication;
KW   RNA-directed RNA polymerase; Transferase.
SQ   SEQUENCE   757 AA;  86371 MW;  8B0AAE352646CE79 CRC64;
     MDVNPTLLFL KVPVQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS EKGKWTTNTE
     TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GIFENSCLET MEIVQQTRVD
     KLTQGRQTYD WTLNRNQPAA TALANTIEIF RSNGLTANES GRLIDFLKDV MESMDKEEME
     ITTHFQRKRR VRDNMTKKMV TQRTIGKKKQ RLNKKSYLIR ALTLNTMTKD AERGKLKRRA
     IATPGMQIRG FVYFVETLAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTELSF
     TITGDNTKWN ENQNPRMFLA MITYITRNQP EWFRNVLSIA PIMFSNKMAR LGKGYMFESK
     SMKLRTQIPA EMLANIDLKY FNELTKKKIE KIRPLLIDGT ASLSPGMMMG MFNMLSTVLG
     VSILNLGQKR YTKTTYWWDG LQSSDDFALI VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK
     KSYINRTGTF EFTSFFYRYG FVANFSMELP SLGVSGINES ADMSIGVTVI KNNMINNDLG
     PATAQMALQL FIKDYRYTYR CHRGDTQIQT RRSFELKKLW EQTRSKAGLL VSDGGPNLYN
     IRNLHIPEAG LKWELMDEDY QGRLCNPLNP FVSHKEIESV NNAVVMPAHG PAKSMEYDAV
     ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF PSSSYRRPVG ISSMVEAMVS
     RARIDARIDF ESGRIKKEEF AEIMKICSTI EELRRQK
//