ID D9ZYE6_9INFA Unreviewed; 757 AA. AC D9ZYE6; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2010, sequence version 1. DT 25-OCT-2017, entry version 36. DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00377010}; DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00376969}; GN Name=PB1 {ECO:0000313|EMBL:ADG59448.1}; OS Influenza A virus (A/chicken/Shandong/A-10/2006(H5N1)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=762394 {ECO:0000313|EMBL:ADG59448.1, ECO:0000313|Proteomes:UP000111231}; RN [1] {ECO:0000313|EMBL:ADG59448.1, ECO:0000313|Proteomes:UP000111231} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/chicken/Shandong/A-10/2006 {ECO:0000313|EMBL:ADG59448.1}; RX PubMed=20538856; DOI=10.1128/JVI.00413-10; RA Li Y., Shi J., Zhong G., Deng G., Tian G., Ge J., Zeng X., Song J., RA Zhao D., Liu L., Jiang Y., Guan Y., Bu Z., Chen H.; RT "Continued evolution of H5N1 influenza viruses in wild birds, domestic RT poultry, and humans in China from 2004 to 2009."; RL J. Virol. 84:8389-8397(2010). CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000256|RuleBase:RU004330, CC ECO:0000256|SAAS:SAAS00605060}. CC -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1 CC family. {ECO:0000256|SAAS:SAAS00565435}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM172376; ADG59448.1; -; Viral_cRNA. DR Proteomes; UP000111231; Genome. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR InterPro; IPR007099; RNA-dir_pol_NSvirus. DR InterPro; IPR001407; RNA_pol_PB1_influenza. DR Pfam; PF00602; Flu_PB1; 1. DR PIRSF; PIRSF000827; RdRPol_OMV; 1. DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000111231}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00605058}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00605055}; KW RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004330, KW ECO:0000256|SAAS:SAAS00605053}; KW Transferase {ECO:0000256|SAAS:SAAS00605061}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00605045}. FT DOMAIN 286 483 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50525}. SQ SEQUENCE 757 AA; 86358 MW; 2402FB5EEC73EA47 CRC64; MDVNPTLLFL KVPVQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS EKGKWTTNTE TGALQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GIFENSCLET MEIVQQTRVD KLTQGRQTYD WTLNRNQPAA TALANTIEIF RSNGLTVNES GRLIDFLKDV MESMDKEEME ITTHFQRKRR VRDNMTKKMV TRRTIGKKKQ RLNKRSYLIR ALTLNTMTKD AERGKLKRRA IATPGMQIRG FVYFVETLAR SICDKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTELSF TITGDNTKWN ENQNPRMFLA MITYITRNQP EWFRNVLSIA PIMFSNKMAR LGKGYMFESK SMKLRTQIPA EMLANIDLKY FNELTKKKIE KIRPLLIDGT ASLSPGMMMG MFNMLSTVLG VSILNLGQKR YTKTTYWWDG LQSSDDFALI VNASNHEGIQ AGVDRFYRTC KLVGINMSKK KSYINRTGTF EFTSFFYRYG FVANFSMELP SFGVSGINES ADMSIGVTVI KNNMINNDLG PATAQMALQL FIKDYRYTYR CHRGDTQIQT RRSFELKKLW EQTRSKAGLL VSDGGPNLYN IRNLHIPEAG LKWELMDEDY QGRLCNPLNP FVSHKEIESV NNAVVMPAHG PAKSMEYDAV ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF PSSSYRRPVG ISSMVEAMVS RARIDARLDF ESGTIKTDEF AEIMTICSTI EELRRQK //