ID D9I6Q2_9INFA Unreviewed; 759 AA. AC D9I6Q2; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2010, sequence version 1. DT 20-DEC-2017, entry version 24. DE RecName: Full=Polymerase basic protein 2 {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943514}; DE Flags: Fragment; GN Name=PB2 {ECO:0000256|RuleBase:RU361246, ECO:0000313|EMBL:ADF83731.1}; OS Influenza A virus (A/Vietnam/UT3047III/2004(H5N1)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=755294 {ECO:0000313|EMBL:ADF83731.1}; RN [1] {ECO:0000313|EMBL:ADF83731.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Vietnam/UT3047III/2004 {ECO:0000313|EMBL:ADF83731.1}; RX PubMed=20592108; DOI=10.1099/vir.0.021659-0; RA Le Q.M., Ito M., Muramoto Y., Hoang P.V., Vuong C.D., Sakai-Tagawa Y., RA Kiso M., Ozawa M., Takano R., Kawaoka Y.; RT "Pathogenicity of highly pathogenic avian H5N1 influenza A viruses RT isolated from humans between 2003 and 2008 in northern Vietnam."; RL J. Gen. Virol. 91:2485-2490(2010). CC -!- FUNCTION: Plays an essential role in transcription initiation and CC cap-stealing mechanism, in which cellular capped pre-mRNAs are CC used to generate primers for viral transcription. CC {ECO:0000256|RuleBase:RU361246}. CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00943502}. CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. CC {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943527}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM114494; ADF83731.1; -; Viral_cRNA. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro. DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW. DR GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW. DR GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR HAMAP; MF_04062; INV_PB2; 1. DR InterPro; IPR001591; INV_PB2. DR InterPro; IPR037258; PDB2_C. DR Pfam; PF00604; Flu_PB2; 1. DR ProDom; PD001667; RNA_pol_PB2_orthomyxovir; 1. DR SUPFAM; SSF160453; SSF160453; 1. PE 3: Inferred from homology; KW Cap snatching {ECO:0000256|SAAS:SAAS00943529}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|SAAS:SAAS00943497}; KW Eukaryotic host transcription shutoff by virus KW {ECO:0000256|SAAS:SAAS00943528}; KW Host gene expression shutoff by virus {ECO:0000256|SAAS:SAAS00943501}; KW Host nucleus {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00943496}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00943506}; KW Inhibition of host RNA polymerase II by virus KW {ECO:0000256|SAAS:SAAS00943508}; KW mRNA capping {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00943498}; KW mRNA processing {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00943500}; KW Viral transcription {ECO:0000256|SAAS:SAAS00943507}; KW Virion {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943495}. FT NON_TER 759 759 {ECO:0000313|EMBL:ADF83731.1}. SQ SEQUENCE 759 AA; 85745 MW; 44A9381CFBBFE953 CRC64; MERIKELRDL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD KRIIEMIPER NEQGQTLWSK TNDAGSDRVM VSPLAVTWWN RNGPATSAVH YPKVYKTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLTITKEKK EELQDCKIAP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQMYTPGGEV RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEVLTGNLQ TLKIRVHEGY EEFTMVGRKA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDMTPS TEMSLRGVRV SKMGVDEYSS TERVVVSIDR FLRVRDQQGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEIN GPESVLVNTY QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF QQMRDVLGTF DTVQIIKLLP FAAAPPEQSR MQFSSLTVNV RGSGMRILVR GNSPVFNYNK ATKRLTVLGK DAGALTEDPD EGTAGVESAV LRGFLILGKE NKRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA TKRIRMAIN //