ID D8UUK5_9INFA Unreviewed; 121 AA. AC D8UUK5; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2010, sequence version 1. DT 31-JAN-2018, entry version 27. DE RecName: Full=Nuclear export protein {ECO:0000256|HAMAP-Rule:MF_04067}; DE Short=NEP {ECO:0000256|HAMAP-Rule:MF_04067}; DE AltName: Full=Non-structural protein 2 {ECO:0000256|HAMAP-Rule:MF_04067}; DE Short=NS2 {ECO:0000256|HAMAP-Rule:MF_04067}; GN Name=NEP {ECO:0000313|EMBL:ACS88984.1}; GN Synonyms=NS {ECO:0000256|HAMAP-Rule:MF_04067, GN ECO:0000256|RuleBase:RU362104}; OS Influenza A virus (A/mink/Sweden/3900/1984(H10N4)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=646302 {ECO:0000313|EMBL:ACS88984.1, ECO:0000313|Proteomes:UP000129542}; RN [1] {ECO:0000313|EMBL:ACS88984.1, ECO:0000313|Proteomes:UP000129542} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/mink/Sweden/3900/1984 {ECO:0000313|EMBL:ACS88984.1}; RA Zohari S., Metreveli G., Kiss I., Belak S., Berg M.; RT "Full genome characterization of mink influenza H10N4 and comparison RT with concomitant avian H10 viruses."; RL J. Gen. Virol. 0:0-0(2009). RN [2] {ECO:0000313|EMBL:ACS88984.1, ECO:0000313|Proteomes:UP000129542} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/mink/Sweden/3900/1984 {ECO:0000313|EMBL:ACS88984.1}; RX PubMed=20591155; RA Zohari S., Metreveli G., Kiss I., Belak S., Berg M.; RT "Full genome comparison and characterization of avian H10 viruses with RT different pathogenicity in Mink (Mustela vison) reveals genetic and RT functional differences in the non-structural gene."; RL Virol. J. 7:145-145(2010). CC -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs CC (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs CC complexes and the nuclear export machinery of the cell. Possesses CC no intrinsic RNA-binding activity, but includes a C-terminal M1- CC binding domain. This domain is believed to allow recognition of CC RNPs bound to the protein M1. Since protein M1 is not available in CC large quantities before late stages of infection, such an indirect CC recognition mechanism probably ensures that genomic RNPs are not CC exported from the host nucleus until sufficient quantities of CC viral mRNA and progeny genomic RNA have been synthesized. CC Furthermore, the RNPs enter the host cytoplasm only when CC associated with the M1 protein that is necessary to guide them to CC the plasma membrane. May down-regulate viral RNA synthesis when CC overproduced. {ECO:0000256|HAMAP-Rule:MF_04067, CC ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967765}. CC -!- SUBUNIT: Binds M1 protein. May interact with host nucleoporin CC RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|RuleBase:RU362104}. CC -!- SUBUNIT: Interacts with protein M1. May interact with host CC nucleoporin RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|HAMAP- CC Rule:MF_04067, ECO:0000256|SAAS:SAAS00967740}. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|HAMAP- CC Rule:MF_04067, ECO:0000256|RuleBase:RU362104, CC ECO:0000256|SAAS:SAAS00967743}. Virion {ECO:0000256|HAMAP- CC Rule:MF_04067, ECO:0000256|RuleBase:RU362104}. CC -!- SIMILARITY: Belongs to the influenza viruses NEP family. CC {ECO:0000256|HAMAP-Rule:MF_04067, ECO:0000256|RuleBase:RU362104, CC ECO:0000256|SAAS:SAAS00967755}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ176140; ACS88984.1; -; Viral_cRNA. DR Proteomes; UP000129542; Genome. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0039675; P:exit of virus from host cell nucleus through nuclear pore; IEA:UniProtKB-UniRule. DR GO; GO:0006405; P:RNA export from nucleus; IEA:UniProtKB-UniRule. DR HAMAP; MF_04067; INFV_NEP; 1. DR InterPro; IPR000968; Flu_NS2. DR Pfam; PF00601; Flu_NS2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000129542}; KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967751}; KW Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967764}; KW Transport {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967760}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967746}. FT MOTIF 12 21 Nuclear export signal. FT {ECO:0000256|HAMAP-Rule:MF_04067}. FT MOTIF 85 94 Nuclear export signal. FT {ECO:0000256|HAMAP-Rule:MF_04067}. SQ SEQUENCE 121 AA; 14347 MW; 57568D2C3E0D4F41 CRC64; MDSNTVSSFH DILMRMSKMQ LGSSSEDLNG MITQFESLKL YRDSLGEAVM RMGDLHSLQS RNGKWREQLS QKFEEIRWLI EEVRHRLKIT ENSFEQITFM QALQLLLEVE QEIRTFSFQL I //