ID D8UUK5_9INFA Unreviewed; 121 AA. AC D8UUK5; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2010, sequence version 1. DT 07-JUN-2017, entry version 23. DE RecName: Full=Nuclear export protein {ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00405215}; DE Short=NEP {ECO:0000256|RuleBase:RU362104}; DE AltName: Full=Non-structural protein 2 {ECO:0000256|RuleBase:RU362104}; GN Name=NEP {ECO:0000313|EMBL:ACS88984.1}; GN Synonyms=NS {ECO:0000256|RuleBase:RU362104}; OS Influenza A virus (A/mink/Sweden/3900/1984(H10N4)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=646302 {ECO:0000313|EMBL:ACS88984.1, ECO:0000313|Proteomes:UP000129542}; RN [1] {ECO:0000313|EMBL:ACS88984.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/mink/Sweden/3900/1984 {ECO:0000313|EMBL:ACS88984.1}; RA Zohari S., Metreveli G., Kiss I., Belak S., Berg M.; RT "Full genome characterization of mink influenza H10N4 and comparison RT with concomitant avian H10 viruses."; RL J. Gen. Virol. 0:0-0(2009). RN [2] {ECO:0000313|EMBL:ACS88984.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/mink/Sweden/3900/1984 {ECO:0000313|EMBL:ACS88984.1}; RX PubMed=20591155; RA Zohari S., Metreveli G., Kiss I., Belak S., Berg M.; RT "Full genome comparison and characterization of avian H10 viruses with RT different pathogenicity in Mink (Mustela vison) reveals genetic and RT functional differences in the non-structural gene."; RL Virol. J. 7:145-145(2010). CC -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs CC (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs CC complexes and the nuclear export machinery of the cell. Possesses CC no intrinsic RNA-binding activity, but includes a C-terminal M1- CC binding domain. This domain is believed to allow recognition of CC RNPs to which the M1 protein is bound. Because the M1 protein is CC not available in large quantities until the later stages of CC infection, such an indirect recognition mechanism probably ensures CC that genomic RNPs are not exported from the nucleus before CC sufficient quantities of viral mRNA and progeny genomic RNA have CC been synthesized. Furthermore, the RNPs enters the cytoplasm only CC when they have associated with the M1 protein that is necessary to CC guide them to the plasma membrane. May down-regulate viral RNA CC synthesis when overproduced. {ECO:0000256|RuleBase:RU362104, CC ECO:0000256|SAAS:SAAS00129355}. CC -!- SUBUNIT: Binds M1 protein. May interact with host nucleoporin CC RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|RuleBase:RU362104}. CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00589355}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU362104}. Host CC nucleus {ECO:0000256|RuleBase:RU362104}. CC -!- SIMILARITY: Belongs to the influenza viruses NEP family. CC {ECO:0000256|RuleBase:RU362104}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ176140; ACS88984.1; -; Viral_cRNA. DR Proteomes; UP000129542; Genome. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0006405; P:RNA export from nucleus; IEA:InterPro. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR InterPro; IPR000968; Flu_NS2. DR Pfam; PF00601; Flu_NS2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000129542}; KW Host nucleus {ECO:0000256|RuleBase:RU362104, KW ECO:0000256|SAAS:SAAS00483614}; KW Host-virus interaction {ECO:0000256|RuleBase:RU362104, KW ECO:0000256|SAAS:SAAS00483594}; KW Transport {ECO:0000256|RuleBase:RU362104, KW ECO:0000256|SAAS:SAAS00483575}; KW Virion {ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00483607}. SQ SEQUENCE 121 AA; 14347 MW; 57568D2C3E0D4F41 CRC64; MDSNTVSSFH DILMRMSKMQ LGSSSEDLNG MITQFESLKL YRDSLGEAVM RMGDLHSLQS RNGKWREQLS QKFEEIRWLI EEVRHRLKIT ENSFEQITFM QALQLLLEVE QEIRTFSFQL I //