ID D8FRZ0_ONCKE Unreviewed; 460 AA. AC D8FRZ0; DT 05-OCT-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2010, sequence version 1. DT 16-SEP-2015, entry version 26. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00248472}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00248467}; GN Name=ND4 {ECO:0000313|EMBL:BAJ09720.1}; OS Oncorhynchus keta (Chum salmon) (Salmo keta). OG Mitochondrion {ECO:0000313|EMBL:BAJ09720.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; OC Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus. OX NCBI_TaxID=8018 {ECO:0000313|EMBL:BAJ09720.1}; RN [1] {ECO:0000313|EMBL:BAJ09720.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Dorsal muscle {ECO:0000313|EMBL:BAJ09720.1}; RX PubMed=16284423; DOI=10.1266/ggs.80.297; RA Shigenobu Y., Saitoh K., Hayashizaki K., Ida H.; RT "Nonsynonymous site heteroplasmy in fish mitochondrial DNA."; RL Genes Genet. Syst. 80:297-301(2005). RN [2] {ECO:0000313|EMBL:BAJ09720.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Dorsal muscle {ECO:0000313|EMBL:BAJ09720.1}; RA Shigenobu Y., Saitoh K.; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:BAJ09720.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Dorsal muscle {ECO:0000313|EMBL:BAJ09720.1}; RX PubMed=20616872; DOI=10.1139/G10-026; RA Garvin M.R., Saitoh K., Churikov D.Y., Brykov V.A., Gharrett A.J.; RT "Single nucleotide polymorphisms in chum salmon (Oncorhynchus keta) RT mitochondrial DNA derived from restriction site haplotype RT information."; RL Genome 53:501-507(2010). RN [4] {ECO:0000313|EMBL:BAJ09720.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Dorsal muscle {ECO:0000313|EMBL:BAJ09720.1}; RA Ishiguro N.B., Saitoh K., Miya M., Nishida M.; RT "Salmoniform mitochondrial genome."; RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP010773; BAJ09720.1; -; Genomic_DNA. DR RefSeq; YP_006280903.1; NC_017838.1. DR GeneID; 12486869; -. DR CTD; 4538; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. DR TIGRFAMs; TIGR01972; NDH_I_M; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAAS:SAAS00307124}; KW Mitochondrion {ECO:0000256|RuleBase:RU000318, KW ECO:0000313|EMBL:BAJ09720.1}; KW NAD {ECO:0000256|RuleBase:RU000317, ECO:0000256|SAAS:SAAS00307154}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000317, KW ECO:0000256|SAAS:SAAS00307100}; KW Transmembrane {ECO:0000256|SAAS:SAAS00307080}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00307085}; KW Ubiquinone {ECO:0000256|RuleBase:RU000318, KW ECO:0000256|SAAS:SAAS00292518}. SQ SEQUENCE 460 AA; 51610 MW; F00F1F6455FEDC33 CRC64; MLKILIPTLM LFPTIWLSPA KWLWTTSIAQ SLIIALASLT WLKWSSETGW SSSNLYLATD PLSTPLLVLT CWLLPLMILA SQNHLSPEPL NRQRTYISLL VSLQTFLILA FGATEIIMFY IMFEATLLPT LIIITRWGNQ TERLNAGTYF LFYTLAGSLP LLVALLLMQN DNGTLSMFTL QYTQPLHLLT WGDKLWWAAC LLAFLVKMPL YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG GYGMMRMMVM LDPLTKELAY PFIVLALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAG GILIQTPWGF TGAIILMIAH GLASSALFCL ANTSYERTHS RTMLLARGMQ MILPLMTTWW FIASLANLAL PPLPNLMGEL MIITSMFNWS YWTLILTGLG TLITASYSLY LFLMTQRGPL PSHIIALEPT HTREHLLIIL HLIPIVLLIL KPELMWGWCF //