ID D7PS99_DANRE Unreviewed; 1041 AA. AC D7PS99; DT 10-AUG-2010, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 1. DT 25-MAY-2022, entry version 63. DE SubName: Full=Integrin alpha 3 protein {ECO:0000313|EMBL:ADI46646.1}; GN Name=itga3b {ECO:0000313|ZFIN:ZDB-GENE-050411-55}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ADI46646.1}; RN [1] {ECO:0000313|EMBL:ADI46646.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=20419147; DOI=10.1371/journal.pgen.1000907; RA Carney T.J., Feitosa N.M., Sonntag C., Slanchev K., Kluger J., Kiyozumi D., RA Gebauer J.M., Coffin Talbot J., Kimmel C.B., Sekiguchi K., Wagener R., RA Schwarz H., Ingham P.W., Hammerschmidt M.; RT "Genetic analysis of fin development in zebrafish identifies furin and RT hemicentin1 as potential novel fraser syndrome disease genes."; RL PLoS Genet. 6:E1000907-E1000907(2010). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}. CC -!- SIMILARITY: Belongs to the integrin alpha chain family. CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU936669; ADI46646.1; -; mRNA. DR RefSeq; NP_001177238.1; NM_001190309.1. DR GeneID; 100331874; -. DR KEGG; dre:100331874; -. DR CTD; 100331874; -. DR ZFIN; ZDB-GENE-050411-55; itga3b. DR OrthoDB; 743479at2759; -. DR PhylomeDB; D7PS99; -. DR ChiTaRS; itga3b; zebrafish. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0008305; C:integrin complex; IBA:GO_Central. DR GO; GO:0005178; F:integrin binding; IBA:GO_Central. DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central. DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central. DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central. DR GO; GO:0033333; P:fin development; IMP:ZFIN. DR GO; GO:0033334; P:fin morphogenesis; IMP:ZFIN. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0050900; P:leukocyte migration; IBA:GO_Central. DR Gene3D; 2.130.10.130; -; 1. DR InterPro; IPR013517; FG-GAP. DR InterPro; IPR013519; Int_alpha_beta-p. DR InterPro; IPR000413; Integrin_alpha. DR InterPro; IPR013649; Integrin_alpha-2. DR InterPro; IPR018184; Integrin_alpha_C_CS. DR InterPro; IPR028994; Integrin_alpha_N. DR InterPro; IPR032695; Integrin_dom_sf. DR Pfam; PF01839; FG-GAP; 2. DR Pfam; PF08441; Integrin_alpha2; 1. DR PRINTS; PR01185; INTEGRINA. DR SMART; SM00191; Int_alpha; 5. DR SUPFAM; SSF69179; SSF69179; 3. DR SUPFAM; SSF69318; SSF69318; 1. DR PROSITE; PS51470; FG_GAP; 3. DR PROSITE; PS00242; INTEGRIN_ALPHA; 1. PE 2: Evidence at transcript level; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889, KW ECO:0000256|RuleBase:RU003762}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003762}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003762}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|RuleBase:RU003762" FT CHAIN 22..1041 FT /evidence="ECO:0000256|RuleBase:RU003762" FT /id="PRO_5001424205" FT TRANSMEM 982..1004 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003762" FT REPEAT 288..349 FT /note="FG-GAP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803" FT REPEAT 350..405 FT /note="FG-GAP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803" FT REPEAT 409..471 FT /note="FG-GAP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803" FT DOMAIN 456..906 FT /note="Integrin_alpha2" FT /evidence="ECO:0000259|Pfam:PF08441" SQ SEQUENCE 1041 AA; 114923 MW; F5870D8743AA40C6 CRC64; MAGKSLHLCV FVICAIQTNT GFNIDVQFPV IKEGKTKGSL FGFSVALHKQ TEKAKKNLLL VGAPQEKAQP QLSKFKINET GAVYYCPITV NLDDCGSMDL ISPPKSTDML EGMWLGVTVA SQRNGGRVLA CGHRYVKKLL GAEEQQRMVG KCYVRGNDLS YDPSDYWQSE TYELCDFNHD QDLEGMCNMG ISGGMTEKDV YFGTPGSFTW QGTVHMKCRD TDSDYAGDAN DRSFGKLGED KFNIYIGYSV LEDIKLLDRS VFTVVMGAPR DEFKGSVILA DKQDLILKQL MNITGEQIGS YFGSCLAVTD LNNDDWNDLI VGAPFYFDRY KEEGGAVYIF MNENGSFQKK ASLVLKGKKG SGFGFAIAAV GDVNQDGFQD IAVGAPFQDS GKVYIWMGSK SGITKEPSQV IEGKSLGPSG FQTFGYSLSG GMDMDGNDYP DILVGSLDDR IALLRSRPVI HLSKNFTVEP KIVIPSQCGN SCIKVKVCFS YTLSNGNSNF RKEITVKFTI DADQNRRGAR VRFIDNKQST FTGLLSFSAS SCQELELSVN NPVTDKLQPI VFSLNVSLNQ QKAEAQQTLQ SLDSFPVLSG QQILTDKAEI NFHKECGDDN RCSSNLQLKA RFADENYNPF PSQTLEFSSN VKKLVLMVEV SNTADENKPA EDAHQATLNI SIPYSLKYSG VRPPAGFDME CSADEAVICD LGNPFKSNQK VSFIIIFETS GITLYTEQIQ SQLQLSTISE QADLFPVLVT LNVKNTILTT FSLEKLIIDT SFSGNVIGES AMSSTSDVGS PLEFVFRVQV LGEPLGDLGT LVIDFDWPYA VANGKWLLYL TEIVIKGSSE SHCVPPGNIV NYLNLTLSKE GTKRNKREVD SGFPHAEASV TVLATRKVAH FLDCSKKTAL CQTFSCPLLN MSTQAEVRVR ARVWNGTLLE DYAKALRVEV KGQATLRLLT DKPAIKMDNQ TREFSVNIDP VLGEETPYEV PLWIIIVAAV AGILLLGIIS LILWKCGFFR RASRREMYEA KSQKAEIKIQ PSETERLTEE F //