ID D7GDR5_PROFC Unreviewed; 410 AA. AC D7GDR5; DT 10-AUG-2010, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 1. DT 16-JAN-2019, entry version 45. DE RecName: Full=Endolytic murein transglycosylase {ECO:0000256|HAMAP-Rule:MF_02065}; DE EC=4.2.2.- {ECO:0000256|HAMAP-Rule:MF_02065}; DE AltName: Full=Peptidoglycan polymerization terminase {ECO:0000256|HAMAP-Rule:MF_02065}; GN Name=mltG {ECO:0000256|HAMAP-Rule:MF_02065}; GN OrderedLocusNames=PFREUD_11540 {ECO:0000313|EMBL:CBL56676.1}; OS Propionibacterium freudenreichii subsp. shermanii (strain ATCC 9614 / OS DSM 4902 / CIP 103027 / NCIMB 8099 / CIRM-BIA1). OC Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae; OC Propionibacterium. OX NCBI_TaxID=754252 {ECO:0000313|EMBL:CBL56676.1, ECO:0000313|Proteomes:UP000000936}; RN [1] {ECO:0000313|EMBL:CBL56676.1, ECO:0000313|Proteomes:UP000000936} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 9614 / DSM 4902 / CIP 103027 / NCIMB 8099 / CIRM-BIA1 RC {ECO:0000313|Proteomes:UP000000936}; RX PubMed=20668525; DOI=10.1371/journal.pone.0011748; RA Falentin H., Deutsch S.M., Jan G., Loux V., Thierry A., Parayre S., RA Maillard M.B., Dherbecourt J., Cousin F.J., Jardin J., Siguier P., RA Couloux A., Barbe V., Vacherie B., Wincker P., Gibrat J.F., RA Gaillardin C., Lortal S.; RT "The complete genome of Propionibacterium freudenreichii CIRM-BIA1, a RT hardy actinobacterium with food and probiotic applications."; RL PLoS ONE 5:E11748-E11748(2010). CC -!- FUNCTION: Functions as a peptidoglycan terminase that cleaves CC nascent peptidoglycan strands endolytically to terminate their CC elongation. {ECO:0000256|HAMAP-Rule:MF_02065}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_02065}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02065}. CC -!- SIMILARITY: Belongs to the transglycosylase MltG family. CC {ECO:0000256|HAMAP-Rule:MF_02065}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FN806773; CBL56676.1; -; Genomic_DNA. DR RefSeq; WP_013161050.1; NC_014215.1. DR ProteinModelPortal; D7GDR5; -. DR STRING; 754252.PFREUD_11540; -. DR EnsemblBacteria; CBL56676; CBL56676; PFREUD_11540. DR GeneID; 29490601; -. DR KEGG; pfr:PFREUD_11540; -. DR eggNOG; ENOG4105HHA; Bacteria. DR eggNOG; COG1559; LUCA. DR HOGENOM; HOG000050564; -. DR KO; K07082; -. DR OMA; LVEGWTF; -. DR OrthoDB; 708179at2; -. DR BioCyc; PFRE754252:PFREUD_RS05590-MONOMER; -. DR Proteomes; UP000000936; Chromosome. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW. DR GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR CDD; cd08010; yceG_like; 1. DR HAMAP; MF_02065; MltG; 1. DR InterPro; IPR003770; YceG. DR PANTHER; PTHR30518; PTHR30518; 1. DR Pfam; PF02618; YceG; 1. DR TIGRFAMs; TIGR00247; TIGR00247; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02065}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02065}; KW Complete proteome {ECO:0000313|Proteomes:UP000000936}; KW Lyase {ECO:0000256|HAMAP-Rule:MF_02065, ECO:0000313|EMBL:CBL56676.1}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_02065}; KW Reference proteome {ECO:0000313|Proteomes:UP000000936}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02065}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02065}. FT TRANSMEM 63 86 Helical. {ECO:0000256|HAMAP-Rule: FT MF_02065}. FT SITE 284 284 Important for catalytic activity. FT {ECO:0000256|HAMAP-Rule:MF_02065}. SQ SEQUENCE 410 AA; 43846 MW; 2413B8CA6BCC46AD CRC64; MAGPKRAADE DAEDLYLPAS RGEEPEPIRS GAATEGPHGP AASGGEQPPL ITMTRDYHRT PGSWLKSVIA VLVSLAVIGG GGFLIYHKVT EYQGADYTGA GQSDVTVTVK SGESVSQMGD LLVAEDVVAS RNAFMRAAKK EKRTNNIQAG TYKMKTRMPA ADVVAVLVDP SNIVNNRFTV PEGLRNTHVL EQVSSATGIA LGQLTAASKD PSLPVPSYAQ GSSEGFLFPD TYTFEPDFTA SQVLTRMVDR FNQVAADENL EKRAAAAGRS PHDVLVVASI IERETSDHKY APLVAEVIYN RLAQGMRLQS DATVAYANNL EGKVTTTDEE RGLNSPYNTY MVDGLPPTPI SNPGKAAIDA ALAPASGDYL YFVTVNLDTG ETKFASDSAG HDQNVKEFQT WCQANSDHCK //