ID   D6RGJ4_HUMAN            Unreviewed;        40 AA.
AC   D6RGJ4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   14-DEC-2022, entry version 68.
DE   SubName: Full=Ras GTPase-activating protein-binding protein 2 {ECO:0000313|Ensembl:ENSP00000426311.2};
GN   Name=G3BP2 {ECO:0000313|Ensembl:ENSP00000426311.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426311.2, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426311.2, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000426311.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2022) to UniProtKB.
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DR   EMBL; AC104828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RGJ4; -.
DR   SMR; D6RGJ4; -.
DR   MaxQB; D6RGJ4; -.
DR   PeptideAtlas; D6RGJ4; -.
DR   ProteomicsDB; 14716; -.
DR   Ensembl; ENST00000509100.6; ENSP00000426311.2; ENSG00000138757.15.
DR   UCSC; uc062xjh.1; human.
DR   HGNC; HGNC:30291; G3BP2.
DR   VEuPathDB; HostDB:ENSG00000138757; -.
DR   GeneTree; ENSGT00390000011365; -.
DR   ChiTaRS; G3BP2; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000138757; Expressed in cortical plate and 204 other tissues.
DR   ExpressionAtlas; D6RGJ4; baseline and differential.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034063; P:stress granule assembly; IEA:InterPro.
DR   InterPro; IPR034377; G3BP2.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR002075; NTF2_dom.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   InterPro; IPR039539; Ras_GTPase_bind_prot.
DR   PANTHER; PTHR10693; RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN; 1.
DR   PANTHER; PTHR10693:SF10; RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 2; 1.
DR   Pfam; PF02136; NTF2; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:D6RGJ4,
KW   ECO:0007829|MaxQB:D6RGJ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          11..40
FT                   /note="NTF2"
FT                   /evidence="ECO:0000259|PROSITE:PS50177"
SQ   SEQUENCE   40 AA;  4926 MW;  1118CF388188700B CRC64;
     MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRIYTTKYYL
//