ID D6QM25_9HEPC Unreviewed; 1651 AA. AC D6QM25; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 24-JUL-2024, entry version 80. DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107}; DE Flags: Fragment; OS Hepacivirus hominis. OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; OC Amarillovirales; Flaviviridae; Hepacivirus. OX NCBI_TaxID=3052230 {ECO:0000313|EMBL:ADG34859.1}; RN [1] {ECO:0000313|EMBL:ADG34859.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=30vSDc21_y00 {ECO:0000313|EMBL:ADG34859.1}; RX PubMed=20200239; DOI=10.1128/JVI.02265-09; RA Liu L., Fisher B.E., Dowd K.A., Astemborski J., Cox A.L., Ray S.C.; RT "Acceleration of hepatitis C virus envelope evolution in humans is RT consistent with progressive humoral immune selection during the transition RT from acute to chronic infection."; RL J. Virol. 84:5067-5077(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001556}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; CC Evidence={ECO:0000256|ARBA:ARBA00001491}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endoplasmic reticulum CC membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004115}. Host cell membrane CC {ECO:0000256|ARBA:ARBA00004165}. Host cytoplasm CC {ECO:0000256|ARBA:ARBA00004192}. Host endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004153}. Host endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004482}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004482}. Host lipid droplet CC {ECO:0000256|ARBA:ARBA00004338}. Host mitochondrion CC {ECO:0000256|ARBA:ARBA00004181}. Host nucleus CC {ECO:0000256|ARBA:ARBA00004147}. Lipid droplet CC {ECO:0000256|ARBA:ARBA00004502}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. Mitochondrion CC {ECO:0000256|ARBA:ARBA00004173}. Virion membrane CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004563}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM000525; ADG34859.1; -; Genomic_RNA. DR MEROPS; S29.001; -. DR euHCVdb; HM000525; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0044186; C:host cell lipid droplet; IEA:UniProtKB-SubCell. DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW. DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW. DR GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW. DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0046718; P:symbiont entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0052170; P:symbiont-mediated suppression of host innate immune response; IEA:UniProtKB-KW. DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW. DR CDD; cd17931; DEXHc_viral_Ns3; 1. DR CDD; cd20903; HCV_p7; 1. DR Gene3D; 2.40.10.120; -; 1. DR Gene3D; 6.10.250.1610; -; 1. DR Gene3D; 6.10.250.1750; -; 1. DR Gene3D; 3.30.160.890; Hepatitis C virus envelope glycoprotein E1, chain C; 1. DR Gene3D; 2.30.30.710; Hepatitis C virus non-structural protein NS2, C-terminal domain; 1. DR Gene3D; 1.20.1280.150; Hepatitis C virus non-structural protein NS2, N-terminal domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR Gene3D; 1.10.820.10; RNA Helicase Chain A , domain 3; 1. DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1. DR InterPro; IPR011492; Flavi_DEAD. DR InterPro; IPR002521; HCV_Core_C. DR InterPro; IPR044896; HCV_core_chain_A. DR InterPro; IPR002522; HCV_core_N. DR InterPro; IPR002519; HCV_Env. DR InterPro; IPR002531; HCV_NS1. DR InterPro; IPR002518; HCV_NS2. DR InterPro; IPR042205; HCV_NS2_C. DR InterPro; IPR042209; HCV_NS2_N. DR InterPro; IPR049913; HCV_p7. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C-like. DR InterPro; IPR004109; HepC_NS3_protease. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin. DR Pfam; PF07652; Flavi_DEAD; 1. DR Pfam; PF01543; HCV_capsid; 1. DR Pfam; PF01542; HCV_core; 1. DR Pfam; PF01539; HCV_env; 1. DR Pfam; PF01560; HCV_NS1; 1. DR Pfam; PF01538; HCV_NS2; 1. DR Pfam; PF02907; Peptidase_S29; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1. DR PROSITE; PS51693; HCV_NS2_PRO; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. DR PROSITE; PS51822; HV_PV_NS3_PRO; 1. PE 4: Predicted; KW Acetylation {ECO:0000256|ARBA:ARBA00022990}; KW Apoptosis {ECO:0000256|ARBA:ARBA00022703}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Capsid protein {ECO:0000256|ARBA:ARBA00022561}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Fusion of virus membrane with host endosomal membrane KW {ECO:0000256|ARBA:ARBA00022510}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|ARBA:ARBA00022506}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511}; KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184}; KW Host lipid droplet {ECO:0000256|ARBA:ARBA00023190}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host mitochondrion {ECO:0000256|ARBA:ARBA00023147}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00022632}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Protease {ECO:0000256|ARBA:ARBA00022670}; KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274}; KW Serine protease {ECO:0000256|ARBA:ARBA00022825}; KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804}; KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}; KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039}; KW Viral nucleoprotein {ECO:0000256|ARBA:ARBA00023086}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}; KW Virion {ECO:0000256|ARBA:ARBA00022844}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT TRANSMEM 351..378 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 718..741 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 753..778 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 785..802 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 814..835 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 891..913 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 903..1026 FT /note="Peptidase C18" FT /evidence="ECO:0000259|PROSITE:PS51693" FT DOMAIN 1027..1208 FT /note="Peptidase S29" FT /evidence="ECO:0000259|PROSITE:PS51822" FT DOMAIN 1217..1369 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51192" FT DOMAIN 1361..1538 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" FT REGION 1..77 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 47..69 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1651 FT /evidence="ECO:0000313|EMBL:ADG34859.1" SQ SEQUENCE 1651 AA; 179408 MW; 19F51152A33164DD CRC64; MSTNPKPQRK TKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR KTSERSQPRG RRQPIPKARR PEGRSWAQPG YPWPLYGNEG CGWAGWLLSP RGSRPSWGPT DPRRRSRNLG KVIDTLTCGF ADLMGYIPLV GAPLGGAARA LAHGVRVLED GVNYATGNLP GCSFSIFLLA LLSCLTVPAS AYQVRNSTGL YHVTNDCPNS SIVYEAADAI LHTPGCVPCV REGNASRCWV AVTPTVATRD GKLPTTQLRR HIDLLVGSAT LCSALYVGDL CGSVFLVGQL FTFSPRRHWT TQGCNCSIYP GHITGHRMAW DMMMNWSPTA ALVVAQLLRI PQAILDMIAG AHWGVLAGMA YFSMVGNWAK VLVVLLLFAG VDAETHVSGG TAARTTARLT NLFSPGAMQN IQLVNTNGSW HINRTALNCN DSLNTGWVAG LFYRYKFNSS GCPERLASCR RLTDFAQGWG PIRYANGSGP DQRPYCWHYP PKPCGFVPAK SVCGPVYCFT PSPVVVGTTD KSGAPTYSWG ENDTDVFVLN NTRPPLGNWF GCTWMNSTGF TKVCGAPPCA IGGVGNNTLL CPTDCFRKHP EATYSRCGSG PWITPRCLVD YPYRLWHYPC TINYTIFKVR MYVGGVEHRL DAACNWTRGE RCDLEDRDRS ELSPLLLSTT QWQVLPCSFT TLPALSTGLI HLHQNIVDVQ YLYGVGSSIA SWAIKWEYVV LLFLLLADAR VCSCLWMMLL ISQAEAALEN LVILNAASLA GTHGLASFLV FFCFAWYLKG RWVPGAVYAL YGMWPLLLLS LALPQRAYAL DTEVAASCGG VVLVGLMALT LSPYYKRYIR WCMWWLQYFL TRAEAQLHIW VPPLNVRGGR DAVILLMCVA HPTLVFDITK LLLAVFGPLW ILQASLLRVP YFVRVQGLLR VCALARKLAG GHYVQMAIIK LGALTGTYVY NHLTPLRNWA HNSLQDLAVA VEPVIFSPME TKLITWGADT AACGDIINGL PVSARRGREI LLGPADGMVS KGWRLLAPIT AYAQQTRGLL GCIITSLTGR DKNQVEGEVQ IVSTAAQTFL ATCINGACWT VYHGAGTRTI ASPKGPVIQM YTNVDKDLVG WPAPQGSRSL TPCTCGSSDL YLVTRHADVI PVRRRGDSRG SLLSPRPISY LKGSSGGPLL CPAGHAVGIF RAAVCTRGVA KAVDFIPVEN LETTMRSPVF TDNSSPPAVP QSFQVAHLHA PTGSGKSTKV PAAYAAQGYK VLVLNPSVAA TLGFGAYMSK AHGIDPNIRT GVRTITTGSS ITYSTYGKFL ADGGCSGGAY DIIICDECHS VDATSILGIG TVLDQAETAG ARLVVLATAT PPGSVTVPHP NIEEVALSTT GEIPFYGKAI PLEVIKGGRH LIFCHSKRKC DELASKLVAL GVNAVAYYRG IDVSVIPTSG DVVVVATDAL MTGFTGDFDS VIDCNTCVTQ TVDFSLDPTF TIETTTLPQD AVSRTQRRGR TGRGKPGIYR FVAPGERPSG MFDSSVLCEC YDAGCAWYEL TPAETTVRLR AYMNTPGLPV CQDHLEFWEG VFTGLTHIDA HFLSQTKQSG ENFPYLVAYQ ATVCARAQAP PPSWDQMWKC LIRLKPTLQG PTPLLYRLGA VQNEVILTHP ITKYIMTCMS A //