ID D6NFS4_ROTGA Unreviewed; 1160 AA. AC D6NFS4; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 05-DEC-2018, entry version 20. DE RecName: Full=RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU364050}; DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU364050}; OS Rotavirus B (isolate RVB/Human/China/ADRV/1982) (RV-B) (Rotavirus B OS (isolate adult diarrhea rotavirus)). OC Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus. OX NCBI_TaxID=10942 {ECO:0000313|EMBL:ADF57882.1, ECO:0000313|Proteomes:UP000168895}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ADF57882.1, ECO:0000313|Proteomes:UP000168895} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=IDH-084 {ECO:0000313|EMBL:ADF57882.1}; RX PubMed=20200192; DOI=10.1099/vir.0.020412-0; RA Yamamoto D., Ghosh S., Ganesh B., Krishnan T., Chawla-Sarkar M., RA Alam M.M., Aung T.S., Kobayashi N.; RT "Analysis of genetic diversity and molecular evolution of human group RT B rotaviruses based on whole genome segments."; RL J. Gen. Virol. 91:1772-1781(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + CC RNA(n+1); Xref=Rhea:RHEA:21248, ChEBI:CHEBI:33019, CC ChEBI:CHEBI:61557, ChEBI:CHEBI:83400, Rhea:RHEA-COMP:11128, CC Rhea:RHEA-COMP:11129; EC=2.7.7.48; CC Evidence={ECO:0000256|RuleBase:RU364050}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU377224; ADF57882.1; -; Genomic_RNA. DR Proteomes; UP000168895; Genome. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR InterPro; IPR001795; RNA-dir_pol_luteovirus. DR InterPro; IPR007097; RNA-dir_pol_reovirus. DR Pfam; PF02123; RdRP_4; 1. DR PROSITE; PS50523; RDRP_DSRNA_REO; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000168895}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU364050}; KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU364050}; KW RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU364050}; KW Transferase {ECO:0000256|RuleBase:RU364050}; KW Viral RNA replication {ECO:0000256|RuleBase:RU364050}. FT DOMAIN 546 728 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50523}. SQ SEQUENCE 1160 AA; 132077 MW; C594AFA6037F28F6 CRC64; MDSFQFFSWL LKDIERNLLY TSLVYTRPRI AIVRYEESEK SRLWESKETN VLSPEEILNK IKDKLDSLSC IHDKIEELLR IRYFTVYVED KSDKRNIILT WLSRTITDLG KHAEYDSIKL IELQARQWRI SNANLLRPYH YNIPINEYLR DNEIELLDTG DNKWKSDTLQ GLLPNFYHRT HTLVGSILYA INSRLDKYST DQKRALSYLL HVIQKCFSEG YLEMSRDRKW NHTLDELRNS RFHLYNAKII HAACAMISLA HSDHIDLEFL CQIITVYSII PANAAKLLSS PMTMYVGVVT FSSHQVASTG NASECSPTTI QNNVYVDKAQ YDEWSNMFNS DPLNASKLLR LMNSNLKTSI EQFSLIFNCF SATFHVGHRI DNAQDAITDQ VTATYTSDID REMYDNYYYR LKNMLKEEII QYVEDHVAKQ YVDVTAESLS ALANSSNGFS KEVTFIDRKI KTTKKILHLD NDLLAGDYND LGKALSHGIP MGTRNVPARQ TRGIFILPWQ VAAIQHTIAE SLYKRAKKGS YQGSFAEAYT AKTASLTYGV LAEDTSKATK IILYTDVSQW DASQHNTEPY RSAWINAIRE ARSEMKWLYS DEPIVLNMNV LDSMIKIQEY LLNSNLIVAS PGSQRPLKII RYHGVASGEK TTKIGNSFAN VALIETVLDS VKQEIPDIEV THLRVDGDDN VVSLTTSCQI SKLQETVKRA YSKLNARVKA LASYTGLEMA KRFIVCGKIF ERGAIPIFTA ERPYGTDVSI QSMCGSSIYS SAVNAYRGFG DSYFAFMQDV LVPPSSSVRI TGRLRVLLSP VTLYATGPLS FEITPQGLGG RCRMYTQSEK LFTLFKLLTQ TVSVSVTPEE IKMYSNTPQF KKRTSVMIKS MQMKLHTEAA ALSRIMIDKE EQKTLGVPNV QSQKNRSQIL KAINILGVPE QSGISPKGYY PEELYSLVIK HSTIKFIDYQ QPIDIYRVNN KAVELLRAQL GVRISDSKPI AKPSNHLYDI VSSISPIKLS PSDLLKQSRK YDLSTYKGKR TYLLDLGLTG NTLKTYLASK LLFRDLLLSK YDELYSTPGF GATQLTTIPL NISSAEKVFS IRLNLPSHLY EIVMLLLLYE YVHYVFMSHK TFIATMHASS QEESARLTKL VLHMLDDIQL DRVSFSDDAW //