ID D6I601_ECOLX Unreviewed; 511 AA. AC D6I601; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 19-JAN-2022, entry version 38. DE RecName: Full=Probable lipid II flippase MurJ {ECO:0000256|HAMAP-Rule:MF_02078}; GN Name=murJ {ECO:0000256|HAMAP-Rule:MF_02078}; GN ORFNames=ECDG_00921 {ECO:0000313|EMBL:EFF07395.2}; OS Escherichia coli B185. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=550676 {ECO:0000313|EMBL:EFF07395.2, ECO:0000313|Proteomes:UP000004669}; RN [1] {ECO:0000313|EMBL:EFF07395.2, ECO:0000313|Proteomes:UP000004669} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B185 {ECO:0000313|EMBL:EFF07395.2, RC ECO:0000313|Proteomes:UP000004669}; RG The Broad Institute Genome Sequencing Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q., RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D., RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J., RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N., RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.; RT "The Genome Sequence of Escherichia coli B185."; RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in peptidoglycan biosynthesis. Transports lipid- CC linked peptidoglycan precursors from the inner to the outer leaflet of CC the cytoplasmic membrane. {ECO:0000256|HAMAP-Rule:MF_02078, CC ECO:0000256|PIRNR:PIRNR002869}. CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02078}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02078}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02078}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass CC membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the MurJ/MviN family. {ECO:0000256|HAMAP- CC Rule:MF_02078, ECO:0000256|PIRNR:PIRNR002869}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG749165; EFF07395.2; -; Genomic_DNA. DR RefSeq; WP_001050683.1; NZ_GG749165.1. DR SMR; D6I601; -. DR EnsemblBacteria; EFF07395; EFF07395; ECDG_00921. DR UniPathway; UPA00219; -. DR Proteomes; UP000004669; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0015648; F:lipid-linked peptidoglycan transporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR CDD; cd13123; MATE_MurJ_like; 1. DR HAMAP; MF_02078; MurJ_MviN; 1. DR InterPro; IPR004268; MurJ. DR Pfam; PF03023; MurJ; 1. DR PIRSF; PIRSF002869; MviN; 1. DR PRINTS; PR01806; VIRFACTRMVIN. DR TIGRFAMs; TIGR01695; murJ_mviN; 1. PE 3: Inferred from homology; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02078}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP- KW Rule:MF_02078}; KW Cell shape {ECO:0000256|ARBA:ARBA00022960, ECO:0000256|HAMAP- KW Rule:MF_02078}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02078, KW ECO:0000256|PIRNR:PIRNR002869}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02078}; KW Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984, ECO:0000256|HAMAP- KW Rule:MF_02078}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_02078}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_02078}; KW Transport {ECO:0000256|HAMAP-Rule:MF_02078, ECO:0000256|PIRNR:PIRNR002869}. FT TRANSMEM 27..45 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 82..110 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 130..154 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 161..182 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 188..205 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 236..262 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 274..292 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 313..334 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 354..371 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 383..402 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 408..429 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 441..466 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" FT TRANSMEM 478..501 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02078" SQ SEQUENCE 511 AA; 55267 MW; CB20FE3CFC9419C2 CRC64; MNLLKSLAAV SSMTMFSRVL GFARDAIVAR IFGAGMATDA FFVAFKLPNL LRRIFAEGAF SQAFVPILAE YKSKQGEDAT RVFVSYVSGL LTLALAVVTV AGMLAAPWVI MVTAPGFADT ADKFALTSQL LKITFPYILL ISLASLVGAI LNTWNRFSIP AFAPTLLNIS MIGFALFAAP YFNPPVLALA WAVTVGGVLQ LVYQLPHLKK IGMLVLPRIN FHDAGAMRVV KQMGPAILGV SVSQISLIIN TIFASFLASG SVSWMYYADR LMEFPSGVLG VALGTILLPS LSKSFASGNH DEYNRLMDWG LRLCFLLALP SAVALGILSG PLTVSLFQYG KFTAFDALMT QRALIAYSVG LIGLIVVKVL APGFYSRQDI KTPVKIAIVT LILTQLMNLA FIGPLKHAGL SLSIGLAACL NASLLYWQLR KQKIFTPQPG WMAFLLRLVV AVLVMSGVLL GMLHIMPEWS LGTMPWRLLR LMAVVLAGIA AYFAALAVLG FKVKEFARRT V //