ID D6C4G1_BOVIN Unreviewed; 359 AA. AC D6C4G1; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 29-MAY-2024, entry version 66. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ADB93147.1}; GN Name=BoLA {ECO:0000313|EMBL:ADB93147.1}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ADB93147.1}; RN [1] {ECO:0000313|EMBL:ADB93147.1} RP NUCLEOTIDE SEQUENCE. RA Li X.Y., Jiang Y.N., Xia C.; RT "Bos taurus BoLA antigen."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AFS51773.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Kidney {ECO:0000313|EMBL:AFS51773.1}; RA Li X., Jiang Y., Li X., Xia C.; RT "New Bovine MHC Class I Sequences."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|ARBA:ARBA00002297}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ952945; ADB93147.1; -; mRNA. DR EMBL; JQ031609; AFS51773.1; -; mRNA. DR RefSeq; NP_001180225.1; NM_001193296.1. DR AlphaFoldDB; D6C4G1; -. DR SMR; D6C4G1; -. DR GeneID; 505676; -. DR CTD; 505676; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt. DR GO; GO:0042605; F:peptide antigen binding; IEA:TreeGrafter. DR GO; GO:0005102; F:signaling receptor binding; IEA:TreeGrafter. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IEA:TreeGrafter. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:TreeGrafter. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:TreeGrafter. DR CDD; cd07698; IgC1_MHC_I_alpha3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022451}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|ARBA:ARBA00022451}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..359 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5010112235" FT TRANSMEM 301..325 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 205..291 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 338..359 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 338..353 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 359 AA; 40140 MW; 6A2F4F095F2216ED CRC64; MGPRTLLLLL SGVLVLTETR AGSHSMRYFS TAVSRPGLGE PRYLEVGYVD DTQFVRFDSD APNPRIEPTA RWVEQEGPEY WHQETQRTKD TAQFFRVYLN TLRGYYNQSE AGSHTVQEMY GCDVGPDGLL RGYDQFAYDG RDYIALNEDL RSWTAADTAA QVTKHNAEAA GDAARVRIYL EGTCVEWLRR YLETGKDTLL RADPPKAHVT HHSISGHEVT LRCWALGFYP EDISLTWQRN GEDQTQDMEL VETRPSGDGN FQKWAALVVP SGEEQKYTCR VQHEGLQEPL TLKWEPPQPS FLTMGIIVGL VLLVVTGAVV AGVVICMKKR SGEKRGTYIQ ASSSDSAQGS DVSLTVPKV //