ID D6BMG7_HBV Unreviewed; 344 AA. AC D6BMG7; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 02-DEC-2020, entry version 33. DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00018175}; DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493}; DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417}; DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180}; DE AltName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149}; DE AltName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00017017}; DE AltName: Full=Ribonuclease H {ECO:0000256|ARBA:ARBA00017721}; DE Flags: Fragment; OS Hepatitis B virus (HBV). OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Blubervirales; Hepadnaviridae; Orthohepadnavirus. OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACV03667.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] {ECO:0000313|EMBL:ACV03667.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=J-27 {ECO:0000313|EMBL:ACV03667.1}; RX PubMed=20034521; DOI=10.1016/j.antiviral.2009.12.006; RA Liu B.M., Li T., Xu J., Li X.G., Dong J.P., Yan P., Yang J.X., Yan L., RA Gao Z.Y., Li W.P., Sun X.W., Wang Y.H., Jiao X.J., Hou C.S., Zhuang H.; RT "Characterization of potential antiviral resistance mutations in hepatitis RT B virus reverse transcriptase sequences in treatment-naive Chinese RT patients."; RL Antiviral Res. 85:512-519(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; CC Evidence={ECO:0000256|ARBA:ARBA00000077}; CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family. CC {ECO:0000256|ARBA:ARBA00007994}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ560988; ACV03667.1; -; Genomic_DNA. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR Gene3D; 3.30.70.270; -; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR001462; DNApol_viral_C. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR000477; RT_dom. DR Pfam; PF00336; DNA_pol_viral_C; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF56672; SSF56672; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW DNA replication {ECO:0000256|ARBA:ARBA00022705}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 11..254 FT /note="Reverse transcriptase" FT /evidence="ECO:0000259|PROSITE:PS50878" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ACV03667.1" FT NON_TER 344 FT /evidence="ECO:0000313|EMBL:ACV03667.1" SQ SEQUENCE 344 AA; 38795 MW; 8F8BF871C84BCE7A CRC64; EDWGPCTEHG EHNIRIPRTP ARVTGGVFLV DKNPHNTTES RLVVDFSQFS RGSTHVSWPK FAVPNLQSLT NLLSSNLSWL SLDVSAAFYH IPLHPAAMPH LLVGSSGLPR YVARLSSTSR NINYQHGTMQ DLHDSCSRHL YVSLLLLYKT FGRKLHLYSH PIILGFRKIP MGVGLSPFLL AQFTSAICSV VRRAFPHCLA FSYMDDVVLG AKSVQHLESL FTSITNFLLS LGIHLNPNKT KRWGYSLNFM GYVIGSWGTL PQEHIVLKLK QCFRKLPVNR PIDWKVCQRI VGLLGFAAPF TQCGYPALMP LYACIQSKQA FTFSPTYKAF LCKQYQNLYP VARQ //