ID   D6BMG7_HBV              Unreviewed;       344 AA.
AC   D6BMG7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   29-APR-2015, entry version 13.
DE   RecName: Full=Protein P {ECO:0000256|SAAS:SAAS00118702};
DE   Flags: Fragment;
OS   Hepatitis B virus (HBV).
OC   Viruses; Retro-transcribing viruses; Hepadnaviridae;
OC   Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:ACV03667.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:ACV03667.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=J-27 {ECO:0000313|EMBL:ACV03667.1};
RA   Baoming L., Tong L., Hui Z.;
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACV03667.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=J-27 {ECO:0000313|EMBL:ACV03667.1};
RX   PubMed=20034521; DOI=10.1016/j.antiviral.2009.12.006;
RA   Liu B.M., Li T., Xu J., Li X.G., Dong J.P., Yan P., Yang J.X., Yan L.,
RA   Gao Z.Y., Li W.P., Sun X.W., Wang Y.H., Jiao X.J., Hou C.S.,
RA   Zhuang H.;
RT   "Characterization of potential antiviral resistance mutations in
RT   hepatitis B virus reverse transcriptase sequences in treatment-naive
RT   Chinese patients.";
RL   Antiviral Res. 85:512-519(2010).
CC   -!- FUNCTION: Multifunctional enzyme that converts the viral RNA
CC       genome into dsDNA in viral cytoplasmic capsids. This enzyme
CC       displays a DNA polymerase activity that can copy either DNA or RNA
CC       templates, and a ribonuclease H (RNase H) activity that cleaves
CC       the RNA strand of RNA-DNA heteroduplexes in a partially processive
CC       3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA
CC       (pgRNA) are encapsidated together with the P protein, and reverse-
CC       transcribed inside the nucleocapsid. Initiation of reverse-
CC       transcription occurs first by binding the epsilon loop on the
CC       pgRNA genome, and is initiated by protein priming, thereby the 5'-
CC       end of (-)DNA is covalently linked to P protein. Partial (+)DNA is
CC       synthesized from the (-)DNA template and generates the relaxed
CC       circular DNA (RC-DNA) genome. After budding and infection, the RC-
CC       DNA migrates in the nucleus, and is converted into a plasmid-like
CC       covalently closed circular DNA (cccDNA). The activity of P protein
CC       does not seem to be necessary for cccDNA generation, and is
CC       presumably released from (+)DNA by host nuclear DNA repair
CC       machinery. {ECO:0000256|SAAS:SAAS00118798}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|SAAS:SAAS00118802}.
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC       phosphomonoester. {ECO:0000256|SAAS:SAAS00118801}.
CC   -!- SIMILARITY: Contains 1 reverse transcriptase domain.
CC       {ECO:0000256|RuleBase:RU000322}.
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DR   EMBL; FJ560988; ACV03667.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|SAAS:SAAS00118795};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00118800};
KW   DNA-directed DNA polymerase {ECO:0000256|SAAS:SAAS00118729};
KW   Endonuclease {ECO:0000256|SAAS:SAAS00118727};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00118728};
KW   Magnesium {ECO:0000256|SAAS:SAAS00118750};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00118726};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00118716};
KW   Nuclease {ECO:0000256|SAAS:SAAS00118722};
KW   Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00118804};
KW   RNA-directed DNA polymerase {ECO:0000256|SAAS:SAAS00118797};
KW   Transferase {ECO:0000256|SAAS:SAAS00118803}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ACV03667.1}.
FT   NON_TER     344    344       {ECO:0000313|EMBL:ACV03667.1}.
SQ   SEQUENCE   344 AA;  38795 MW;  8F8BF871C84BCE7A CRC64;
     EDWGPCTEHG EHNIRIPRTP ARVTGGVFLV DKNPHNTTES RLVVDFSQFS RGSTHVSWPK
     FAVPNLQSLT NLLSSNLSWL SLDVSAAFYH IPLHPAAMPH LLVGSSGLPR YVARLSSTSR
     NINYQHGTMQ DLHDSCSRHL YVSLLLLYKT FGRKLHLYSH PIILGFRKIP MGVGLSPFLL
     AQFTSAICSV VRRAFPHCLA FSYMDDVVLG AKSVQHLESL FTSITNFLLS LGIHLNPNKT
     KRWGYSLNFM GYVIGSWGTL PQEHIVLKLK QCFRKLPVNR PIDWKVCQRI VGLLGFAAPF
     TQCGYPALMP LYACIQSKQA FTFSPTYKAF LCKQYQNLYP VARQ
//