ID D5LBD8_HBV Unreviewed; 400 AA. AC D5LBD8; DT 15-JUN-2010, integrated into UniProtKB/TrEMBL. DT 15-JUN-2010, sequence version 1. DT 11-JUL-2012, entry version 10. DE RecName: Full=Large envelope protein; GN Name=S; ORFNames=HBVgp2; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A2-10, and A2-2; RX PubMed=20089644; DOI=10.1128/JVI.02164-09; RA Wang H.Y., Chien M.H., Huang H.P., Chang H.C., Wu C.C., Chen P.J., RA Chang M.H., Chen D.S.; RT "Distinct hepatitis B virus dynamics in the immunotolerant and early RT immunoclearance phases."; RL J. Virol. 84:3454-3463(2010). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A2-10, and A2-2; RA Wang H.-Y., Chien M.-H., Huang H.-P., Chang H.-C., Wu C.-C., RA Chen P.-J., Chang M.-H., Chen D.-S.; RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The middle envelope protein plays an important role in CC the budding of the virion. It is involved in the induction of CC budding in a nucleocapsid independent way. In this process the CC majority of envelope proteins bud to form subviral lipoprotein CC particles of 22 nm of diameter that do not contain a nucleocapsid CC (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU815561; ADF05703.1; -; Genomic_DNA. DR EMBL; GU815569; ADF05759.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. DR GO; GO:0016032; P:viral reproduction; IEA:InterPro. DR InterPro; IPR000349; Hepvir_surfAg. DR Pfam; PF00695; vMSA; 1. PE 3: Inferred from homology; KW Fusion of virus membrane with host membrane; Host-virus interaction; KW Membrane; Transmembrane; Viral attachment to host cell; KW Viral penetration into host cytoplasm; Virion; KW Virus entry into host cell. SQ SEQUENCE 400 AA; 43715 MW; 51B5C03A3692694D CRC64; MGGWSSKPRK GMGTNLSVPN PLGFFPDHQL DPAFKANSEN PDWDLNPHKD NWPDANKVGV GAFGPGFTPP HGGLLGWSPQ AQGLLTTVPA APPPASTNRQ SGRQPTPLSP PLRDTHPQAM QWNSTTFHQT LQDPRVRALY FPAGGSSSGT VSPAQNTVSA ISSILSKTGD PVPNMENIAS GLLGPLLVLQ AGFFLLTKIL TIPQSLDSWW TSLNFLGGTP VCLGQNSQSQ ISSHSPTCCP PICPGYRWMC LRRFIIFLCI LLLCLIFLLV LLDYQGMLPV CPLIPGSSTT STGPCKTCTT PAQGTSMFPS CCCTKPTDGN CTCIPIPSSW AFAKYLWEWA SVRFSWLSLL VPFVQWFVGL SPIVWLSVIW MMWFWGPSLY NILSPFIPLL PIFFCLWVYI //