ID D5G334_CANLF Unreviewed; 170 AA. AC D5G334; DT 15-JUN-2010, integrated into UniProtKB/TrEMBL. DT 15-JUN-2010, sequence version 1. DT 29-MAY-2024, entry version 52. DE RecName: Full=Apolipoprotein E {ECO:0000256|ARBA:ARBA00019891}; DE Flags: Fragment; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615 {ECO:0000313|EMBL:ADB55604.1}; RN [1] {ECO:0000313|EMBL:ADB55604.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tu001 {ECO:0000313|EMBL:ADB55604.1}; RA Leelamanit W., Jittikoon J.; RT "Apolipoprotein E4 gene is conserved through out mammal species."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Homotetramer. May interact with ABCA1; functionally associated CC with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid- CC beta peptide; the interaction is extremely stable in vitro but its CC physiological significance is unclear. May interact with MAPT. May CC interact with MAP2. In the cerebrospinal fluid, interacts with secreted CC SORL1. Interacts with PMEL; this allows the loading of PMEL luminal CC fragment on ILVs to induce fibril nucleation. CC {ECO:0000256|ARBA:ARBA00034326}. CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body CC {ECO:0000256|ARBA:ARBA00004559}. Extracellular vesicle CC {ECO:0000256|ARBA:ARBA00034305}. Secreted, extracellular space CC {ECO:0000256|ARBA:ARBA00004239}. Vesicle CC {ECO:0000256|ARBA:ARBA00004373}. CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family. CC {ECO:0000256|ARBA:ARBA00008788}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ948095; ADB55604.1; -; Genomic_DNA. DR AlphaFoldDB; D5G334; -. DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW. DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW. DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:TreeGrafter. DR GO; GO:0005771; C:multivesicular body; IEA:UniProtKB-SubCell. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW. DR GO; GO:0001540; F:amyloid-beta binding; IEA:TreeGrafter. DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:TreeGrafter. DR GO; GO:0070326; F:very-low-density lipoprotein particle receptor binding; IEA:TreeGrafter. DR GO; GO:0006707; P:cholesterol catabolic process; IEA:TreeGrafter. DR GO; GO:0006869; P:lipid transport; IEA:InterPro. DR GO; GO:0042159; P:lipoprotein catabolic process; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:1900221; P:regulation of amyloid-beta clearance; IEA:TreeGrafter. DR Gene3D; 1.20.120.20; Apolipoprotein; 2. DR InterPro; IPR000074; ApoA_E. DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1. DR PANTHER; PTHR18976:SF2; APOLIPOPROTEIN E; 1. DR Pfam; PF01442; Apolipoprotein; 1. DR SUPFAM; SSF58113; Apolipoprotein A-I; 1. PE 3: Inferred from homology; KW Chylomicron {ECO:0000256|ARBA:ARBA00022513}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW HDL {ECO:0000256|ARBA:ARBA00022850}; KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674}; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Lipoprotein {ECO:0000313|EMBL:ADB55604.1}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW VLDL {ECO:0000256|ARBA:ARBA00023313}. FT COILED 6..33 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 123..165 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ADB55604.1" FT NON_TER 170 FT /evidence="ECO:0000313|EMBL:ADB55604.1" SQ SEQUENCE 170 AA; 19868 MW; DB0AA1CCEEB5BFA5 CRC64; ELQAAQARLR SDMEDVRNRL TQYRGELQAM LGQSSEELRA RFASHMRKLR KRVLRDAEDL QRRLAVYKAG VREGAERSVS SIRERLWPLL EQARERNAKV GALATQPLLE RADALGQQLR GQLEEMSSRA RGHLEEMREQ IQEVRVKMEE QADQIRQKAE AFQARLKSWF //