ID D5FJ60_CERSC Unreviewed; 125 AA. AC D5FJ60; DT 15-JUN-2010, integrated into UniProtKB/TrEMBL. DT 15-JUN-2010, sequence version 1. DT 22-FEB-2023, entry version 20. DE SubName: Full=NADH dehydrogenase subunit 4 {ECO:0000313|EMBL:ACX85620.1}; DE Flags: Fragment; GN Name=ND4 {ECO:0000313|EMBL:ACX85620.1}; OS Ceratotherium simum cottoni (Northern white rhinoceros). OG Mitochondrion {ECO:0000313|EMBL:ACX85620.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Ceratotherium. OX NCBI_TaxID=310713 {ECO:0000313|EMBL:ACX85620.1}; RN [1] {ECO:0000313|EMBL:ACX85620.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Zaire {ECO:0000313|EMBL:ACX85620.1}; RX PubMed=20383328; DOI=10.1371/journal.pone.0009703; RA Groves C.P., Fernando P., Robovsky J.; RT "The sixth rhino: a taxonomic re-assessment of the critically endangered RT northern white rhinoceros."; RL PLoS ONE 5:E9703-E9703(2010). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000256|ARBA:ARBA00024313}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|ARBA:ARBA00009025}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ608800; ACX85620.1; -; Genomic_DNA. DR AlphaFoldDB; D5FJ60; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1. DR PANTHER; PTHR43507:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000313|EMBL:ACX85620.1}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 21..41 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 61..79 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 99..122 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..109 FT /note="NADH:ubiquinone oxidoreductase chain 4 N-terminal" FT /evidence="ECO:0000259|Pfam:PF01059" FT NON_TER 125 FT /evidence="ECO:0000313|EMBL:ACX85620.1" SQ SEQUENCE 125 AA; 14403 MW; BCC723F903F3C839 CRC64; MLKIIIPTLM LIPLTWLSKN SMIWINTTAY SLLISFISLP LLSQFNENSL NMSLTFFSDP LSAPLLVLTT WLLPLMIMAS QHHLSKEPLA RKKLYITMLI TLQTFLIMTF TATELIFFYI LFEAT //