ID COBD_RHOCB Reviewed; 314 AA. AC D5AV16; O68090; Q52683; DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot. DT 15-JUN-2010, sequence version 1. DT 10-FEB-2021, entry version 57. DE RecName: Full=Cobalamin biosynthesis protein CobD; GN Name=cobD; Synonyms=bluD; OrderedLocusNames=RCAP_rcc02054; OS Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; OC Rhodobacteraceae; Rhodobacter. OX NCBI_TaxID=272942; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003; RX PubMed=9256491; DOI=10.1073/pnas.94.17.9384; RA Vlcek C., Paces V., Maltsev N., Paces J., Haselkorn R., Fonstein M.; RT "Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus RT SB1003."; RL Proc. Natl. Acad. Sci. U.S.A. 94:9384-9388(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003; RX PubMed=20418398; DOI=10.1128/jb.00366-10; RA Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., RA Haselkorn R.; RT "Complete genome sequence of the photosynthetic purple nonsulfur bacterium RT Rhodobacter capsulatus SB 1003."; RL J. Bacteriol. 192:3545-3546(2010). CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of CC aminopropanol on the F carboxylic group. {ECO:0000250}. CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF010496; AAC16177.1; -; Genomic_DNA. DR EMBL; CP001312; ADE85798.1; -; Genomic_DNA. DR PIR; T03524; T03524. DR RefSeq; WP_013067777.1; NC_014034.1. DR STRING; 272942.RCAP_rcc02054; -. DR EnsemblBacteria; ADE85798; ADE85798; RCAP_rcc02054. DR KEGG; rcp:RCAP_rcc02054; -. DR eggNOG; COG1270; Bacteria. DR HOGENOM; CLU_054212_0_1_5; -. DR OMA; HPVQVMG; -. DR OrthoDB; 2029688at2; -. DR BioCyc; RCAP272942:G1GUE-2059-MONOMER; -. DR UniPathway; UPA00148; -. DR Proteomes; UP000002361; Chromosome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015420; F:ATPase-coupled vitamin B12 transmembrane transporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro. DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway. DR HAMAP; MF_00024; CobD_CbiB; 1. DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB. DR PANTHER; PTHR34308; PTHR34308; 1. DR Pfam; PF03186; CobD_Cbib; 1. DR TIGRFAMs; TIGR00380; cobD; 1. PE 3: Inferred from homology; KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome; KW Transmembrane; Transmembrane helix. FT CHAIN 1..314 FT /note="Cobalamin biosynthesis protein CobD" FT /id="PRO_0000409929" FT TRANSMEM 3..23 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 57..77 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 78..98 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 154..174 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 290..310 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 314 AA; 33407 MW; DE5F599A91DB46D8 CRC64; MNFAAMMVVA IGIDLALGWP DALYKRIGHP VTWIGALIAR LEKGWNFKGR LRRLRGVLVA LAVIGTTVVI ALAVQLWLPA GWPGVLIGGI LAWPFVALRS MHDHVAAVAK PLIAGDLPGA RQAVSMIVGR DPSQLDQPGV ARAALESLAE NSSDGIVAPL FWGCVAGLPG IAGYKAINTL DSMIGHRTDR YEEFGWASAR IDDLVNLIPA RLTGLFFALA SPCRARALAV MARDARSHRS PNAGWPEAAM AGALAVRLSG PRIYADRVAN EPWLNGTAPD PRPADLARGL ALYRRAMAGM TLVIGLVAVL WSVS //