ID D4EXZ2_ENTFL Unreviewed; 229 AA. AC D4EXZ2; DT 18-MAY-2010, integrated into UniProtKB/TrEMBL. DT 18-MAY-2010, sequence version 1. DT 02-DEC-2020, entry version 46. DE RecName: Full=50S ribosomal protein L1 {ECO:0000256|HAMAP-Rule:MF_01318}; GN Name=rplA {ECO:0000256|HAMAP-Rule:MF_01318, GN ECO:0000313|EMBL:EFE15485.1}; GN ORFNames=EYB36_13345 {ECO:0000313|EMBL:QGI56761.1}, HMPREF9377_02416 GN {ECO:0000313|EMBL:EFE15485.1}; OS Enterococcus faecalis R712. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; OC Enterococcus. OX NCBI_TaxID=699186 {ECO:0000313|EMBL:EFE15485.1, ECO:0000313|Proteomes:UP000005474}; RN [1] {ECO:0000313|EMBL:EFE15485.1, ECO:0000313|Proteomes:UP000005474} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=R712 {ECO:0000313|EMBL:EFE15485.1, RC ECO:0000313|Proteomes:UP000005474}; RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L., RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C., RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A., RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W., RA Chinwalla A., Mardis E.R., Wilson R.K.; RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:QGI56761.1, ECO:0000313|Proteomes:UP000375467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=R712 {ECO:0000313|EMBL:QGI56761.1, RC ECO:0000313|Proteomes:UP000375467}; RA Khan A., Davlieva M., Panesso D., Rincon S., Miller W.R., Diaz L., RA Reyes J., Cruz M.R., Siegel S.D., Planet P.J., Narechania A., Latorre M., RA Rios R., Singh K., Ton-That H., Garsin D.A., Tran T., Shamoo Y., RA Arias C.A.; RT "Antimicrobial Sensing Coupled with Cell Membrane Remodeling Mediates RT Antibiotic Resistance and Virulence in Enterococcus #faecalis."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds directly to 23S rRNA. The L1 stalk is quite mobile in CC the ribosome, and is involved in E site tRNA release. CC {ECO:0000256|HAMAP-Rule:MF_01318}. CC -!- FUNCTION: Protein L1 is also a translational repressor protein, it CC controls the translation of the L11 operon by binding to its mRNA. CC {ECO:0000256|HAMAP-Rule:MF_01318}. CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000256|HAMAP- CC Rule:MF_01318}. CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL1 family. CC {ECO:0000256|ARBA:ARBA00010531, ECO:0000256|HAMAP-Rule:MF_01318, CC ECO:0000256|RuleBase:RU000659}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ADDQ01000079; EFE15485.1; -; Genomic_DNA. DR EMBL; CP036249; QGI56761.1; -; Genomic_DNA. DR RefSeq; WP_002356425.1; NZ_GG739886.1. DR SMR; D4EXZ2; -. DR EnsemblBacteria; EFE15485; EFE15485; HMPREF9377_02416. DR GeneID; 50462658; -. DR HOGENOM; CLU_062853_0_0_9; -. DR Proteomes; UP000005474; Unassembled WGS sequence. DR Proteomes; UP000375467; Chromosome. DR GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW. DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule. DR CDD; cd00403; Ribosomal_L1; 1. DR Gene3D; 3.40.50.790; -; 1. DR HAMAP; MF_01318_B; Ribosomal_L1_B; 1. DR InterPro; IPR005878; Ribosom_L1_bac-type. DR InterPro; IPR002143; Ribosomal_L1. DR InterPro; IPR023674; Ribosomal_L1-like. DR InterPro; IPR028364; Ribosomal_L1/biogenesis. DR InterPro; IPR016095; Ribosomal_L1_3-a/b-sand. DR InterPro; IPR023673; Ribosomal_L1_CS. DR Pfam; PF00687; Ribosomal_L1; 1. DR PIRSF; PIRSF002155; Ribosomal_L1; 1. DR SUPFAM; SSF56808; SSF56808; 1. DR TIGRFAMs; TIGR01169; rplA_bact; 1. DR PROSITE; PS01199; RIBOSOMAL_L1; 1. PE 3: Inferred from homology; KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_01318}; KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, ECO:0000256|HAMAP- KW Rule:MF_01318, ECO:0000256|RuleBase:RU000659}; KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980, ECO:0000256|HAMAP- KW Rule:MF_01318, ECO:0000256|RuleBase:RU000659, ECO:0000313|EMBL:EFE15485.1}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP- KW Rule:MF_01318}; KW rRNA-binding {ECO:0000256|ARBA:ARBA00022730, ECO:0000256|HAMAP- KW Rule:MF_01318}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845, ECO:0000256|HAMAP- KW Rule:MF_01318}; tRNA-binding {ECO:0000256|HAMAP-Rule:MF_01318}. SQ SEQUENCE 229 AA; 24460 MW; 0F2E11FF602C38C2 CRC64; MAKKSKKMQE ALKKVDATKA YSVEEAVALA KDTNIAKFDA TVEVAYKLNV DPKKADQQIR GAVVLPNGTG KTQTVLVFAK GEKAKEAEAA GADFVGDDDM VAKIQGGWFD FDVVVATPDM MATVGKLGRV LGPKGLMPNP KTGTVTMDVT KAVEEVKAGK VTYRVDKAGN IHVPIGKVSF DNEKLVENFN TINDVLLKAK PSTAKGQYIK NISVTTTFGP GIHVDQASF //