ID D3Z6Q7_MOUSE Unreviewed; 267 AA. AC D3Z6Q7; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 29-MAY-2024, entry version 99. DE SubName: Full=Transcription factor EB {ECO:0000313|Ensembl:ENSMUSP00000108909.2}; GN Name=Tfeb {ECO:0000313|Ensembl:ENSMUSP00000108909.2, GN ECO:0000313|MGI:MGI:103270}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000108909.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000108909.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108909.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000108909.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108909.2}; RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the MiT/TFE family. CC {ECO:0000256|ARBA:ARBA00008289}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3Z6Q7; -. DR SMR; D3Z6Q7; -. DR jPOST; D3Z6Q7; -. DR MaxQB; D3Z6Q7; -. DR PeptideAtlas; D3Z6Q7; -. DR ProteomicsDB; 320313; -. DR Antibodypedia; 15889; 696 antibodies from 44 providers. DR Ensembl; ENSMUST00000113284.8; ENSMUSP00000108909.2; ENSMUSG00000023990.19. DR AGR; MGI:103270; -. DR MGI; MGI:103270; Tfeb. DR VEuPathDB; HostDB:ENSMUSG00000023990; -. DR GeneTree; ENSGT00940000159691; -. DR HOGENOM; CLU_031638_3_0_1; -. DR OMA; XELEMQA; -. DR ChiTaRS; Tfeb; mouse. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000023990; Expressed in hindlimb stylopod muscle and 188 other cell types or tissues. DR ExpressionAtlas; D3Z6Q7; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter. DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR InterPro; IPR031867; MiT/TFE_N. DR PANTHER; PTHR45776; MIP04163P; 1. DR PANTHER; PTHR45776:SF5; TRANSCRIPTION FACTOR EB; 1. DR Pfam; PF00010; HLH; 1. DR Pfam; PF15951; MITF_TFEB_C_3_N; 1. DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1. DR PROSITE; PS50888; BHLH; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|EPD:D3Z6Q7, KW ECO:0007829|MaxQB:D3Z6Q7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 234..267 FT /note="BHLH" FT /evidence="ECO:0000259|PROSITE:PS50888" FT REGION 1..54 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 22..49 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 267 AA; 29797 MW; 6457B8A0A262B725 CRC64; MASRIGLRMQ LMREQAQQEE QRERMQQQAV MHYMQQQQQQ QQQLGGPPTP AINTPVHFQS PPPVPGEVLK VQSYLENPTS YHLQQSQHQK VREYLSETYG NKFAAHVSPA QGSPKPAPAA SPGVRAGHVL STSAGNSAPN SPMAMLHISS NPEKEFDDVI DNIMRLDSVL GYINPEMQMP NTLPLSSSHL NVYSGDPQVT ASMVGVTSSS CPADLTQKRE LTDAESRALA KERQKKDNHN LIERRRRFNI NDRIKELGML IPKANDL //