ID D3Z6Q7_MOUSE Unreviewed; 267 AA. AC D3Z6Q7; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-MAY-2015, entry version 43. DE SubName: Full=Transcription factor EB {ECO:0000313|Ensembl:ENSMUSP00000108909}; GN Name=Tfeb {ECO:0000313|Ensembl:ENSMUSP00000108909, GN ECO:0000313|MGI:MGI:103270}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000108909, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000108909, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108909, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000108909} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108909}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC {ECO:0000256|RuleBase:RU000367}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000108909}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC113536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC124830; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D3Z6Q7; -. DR SMR; D3Z6Q7; 235-266. DR PRIDE; D3Z6Q7; -. DR Ensembl; ENSMUST00000113284; ENSMUSP00000108909; ENSMUSG00000023990. DR MGI; MGI:103270; Tfeb. DR GeneTree; ENSGT00390000004402; -. DR HOGENOM; HOG000231368; -. DR ChiTaRS; Tfeb; mouse. DR NextBio; 35551512; -. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; D3Z6Q7; -. DR ExpressionAtlas; D3Z6Q7; baseline and differential. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0005667; C:transcription factor complex; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0044212; F:transcription regulatory region DNA binding; ISO:MGI. DR GO; GO:0006959; P:humoral immune response; IEA:InterPro. DR GO; GO:0007040; P:lysosome organization; ISO:MGI. DR GO; GO:0010508; P:positive regulation of autophagy; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR024098; TFEB. DR PANTHER; PTHR10014:SF9; PTHR10014:SF9; 1. DR Pfam; PF00010; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:D3Z6Q7, KW ECO:0000213|PeptideAtlas:D3Z6Q7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 267 AA; 29797 MW; 6457B8A0A262B725 CRC64; MASRIGLRMQ LMREQAQQEE QRERMQQQAV MHYMQQQQQQ QQQLGGPPTP AINTPVHFQS PPPVPGEVLK VQSYLENPTS YHLQQSQHQK VREYLSETYG NKFAAHVSPA QGSPKPAPAA SPGVRAGHVL STSAGNSAPN SPMAMLHISS NPEKEFDDVI DNIMRLDSVL GYINPEMQMP NTLPLSSSHL NVYSGDPQVT ASMVGVTSSS CPADLTQKRE LTDAESRALA KERQKKDNHN LIERRRRFNI NDRIKELGML IPKANDL //