ID D3Z6Q3_MOUSE Unreviewed; 706 AA. AC D3Z6Q3; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-NOV-2024, entry version 113. DE SubName: Full=Forkhead box P1 {ECO:0000313|Ensembl:ENSMUSP00000108954.3}; GN Name=Foxp1 {ECO:0000313|Ensembl:ENSMUSP00000108954.3, GN ECO:0000313|MGI:MGI:1914004}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000108954.3, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000108954.3, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108954.3, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000108954.3} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108954.3}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000108954.3} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108954.3}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00089}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006505377.1; XM_006505314.3. DR AlphaFoldDB; D3Z6Q3; -. DR SMR; D3Z6Q3; -. DR PeptideAtlas; D3Z6Q3; -. DR DNASU; 108655; -. DR Ensembl; ENSMUST00000113328.9; ENSMUSP00000108954.3; ENSMUSG00000030067.18. DR GeneID; 108655; -. DR UCSC; uc009dbk.2; mouse. DR AGR; MGI:1914004; -. DR CTD; 27086; -. DR MGI; MGI:1914004; Foxp1. DR VEuPathDB; HostDB:ENSMUSG00000030067; -. DR GeneTree; ENSGT00940000159892; -. DR OrthoDB; 5385885at2759; -. DR PhylomeDB; D3Z6Q3; -. DR BioGRID-ORCS; 108655; 6 hits in 79 CRISPR screens. DR ChiTaRS; Foxp1; mouse. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000030067; Expressed in caudate-putamen and 314 other cell types or tissues. DR ExpressionAtlas; D3Z6Q3; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR CDD; cd20065; FH_FOXP2; 1. DR FunFam; 1.20.5.340:FF:000005; Forkhead box P1, isoform CRA_f; 1. DR FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1. DR Gene3D; 1.20.5.340; -; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR047412; FH_FOXP1_P2. DR InterPro; IPR001766; Fork_head_dom. DR InterPro; IPR050998; FOXP. DR InterPro; IPR032354; FOXP-CC. DR InterPro; IPR030456; TF_fork_head_CS_2. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1. DR PANTHER; PTHR45796:SF3; FORKHEAD BOX PROTEIN P1; 1. DR Pfam; PF00250; Forkhead; 1. DR Pfam; PF16159; FOXP-CC; 1. DR PRINTS; PR00053; FORKHEAD. DR SMART; SM00339; FH; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00658; FORK_HEAD_2; 1. DR PROSITE; PS50039; FORK_HEAD_3; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}; KW Proteomics identification {ECO:0007829|PeptideAtlas:D3Z6Q3, KW ECO:0007829|ProteomicsDB:D3Z6Q3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Repressor {ECO:0000256|ARBA:ARBA00022491}; KW Transcription {ECO:0000256|ARBA:ARBA00023015}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. FT DOMAIN 494..567 FT /note="Fork-head" FT /evidence="ECO:0000259|PROSITE:PS50039" FT DNA_BIND 494..567 FT /note="Fork-head" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089" FT REGION 1..41 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 268..287 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 292..327 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 419..451 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 640..706 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 62..107 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1..24 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 292..315 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 419..434 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 640..654 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 706 AA; 78961 MW; 5DFE52B3577CB451 CRC64; MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ QQVATQQLAF QQQLLQMQQL QQQHLLSLQR QGLLTIQPGQ PALPLQPLAQ GMIPTELQQL WKEVTSAHTA EETTSSNHSS LDLTSTCVSS SAPSKSSLIM NPHASTNGQL SVHTPKRESL SHEEHPHSHP LYGHGVCKWP GCEAVCDDFP AFLKHLNSEH ALDDRSTAQC RVQMQVVQQL ELQLAKDKER LQAMMTHLHV KSTEPKAAPQ PLNLVSSVTL SKSASEASPQ SLPHTPTTPT APLTPVTQGP SVITTTSMHT VGPIRRRYSD KYNVPISSAD IAQNQEFYKN AEVRPPFTYA SLIRQAILES PEKQLTLNEI YNWFTRMFAY FRRNAATWKN AVRHNLSLHK CFVRVENVKG AVWTVDEVEF QKRRPQKISG NPSLIKNMQS SHAYCTPLNA ALQASMAENS IPLYTTASMG NPTLGSLASA IREELNGAME HTNSNESDSS PGRSPMQAVH PIHVKEEPLD PEEAEGPLSL VTTANHSPDF DHDRDYEDEP VNEDME //