ID D3Z2G1_MOUSE Unreviewed; 178 AA. AC D3Z2G1; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 02-OCT-2024, entry version 78. DE RecName: Full=3',5'-cyclic-AMP phosphodiesterase {ECO:0000256|ARBA:ARBA00012276}; DE EC=3.1.4.53 {ECO:0000256|ARBA:ARBA00012276}; DE Flags: Fragment; GN Name=Pde4c {ECO:0000313|Ensembl:ENSMUSP00000119312.2, GN ECO:0000313|MGI:MGI:99556}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119312.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000119312.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119312.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000119312.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119312.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000119312.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119312.2}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, CC ChEBI:CHEBI:456215; EC=3.1.4.53; CC Evidence={ECO:0000256|ARBA:ARBA00033681}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; CC Evidence={ECO:0000256|ARBA:ARBA00033681}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from CC 3',5'-cyclic AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004703}. CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. CC PDE4 subfamily. {ECO:0000256|ARBA:ARBA00009517}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3Z2G1; -. DR SMR; D3Z2G1; -. DR ProteomicsDB; 302274; -. DR Ensembl; ENSMUST00000123739.8; ENSMUSP00000119312.2; ENSMUSG00000031842.16. DR AGR; MGI:99556; -. DR MGI; MGI:99556; Pde4c. DR VEuPathDB; HostDB:ENSMUSG00000031842; -. DR GeneTree; ENSGT00940000162285; -. DR HOGENOM; CLU_1513974_0_0_1; -. DR OMA; DAVQTHR; -. DR UniPathway; UPA00762; UER00747. DR ChiTaRS; Pde4c; mouse. DR Proteomes; UP000000589; Chromosome 8. DR Bgee; ENSMUSG00000031842; Expressed in cortex of kidney and 47 other cell types or tissues. DR ExpressionAtlas; D3Z2G1; baseline and differential. DR GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-EC. DR GO; GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway. DR InterPro; IPR040844; PDE4_UCR. DR PANTHER; PTHR40141:SF3; 3',5'-CYCLIC-AMP PHOSPHODIESTERASE; 1. DR PANTHER; PTHR40141; 3',5'-CYCLIC-AMP PHOSPHODIESTERASE-RELATED; 1. DR Pfam; PF18100; PDE4_UCR; 1. PE 1: Evidence at protein level; KW cAMP {ECO:0000256|ARBA:ARBA00023149}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Proteomics identification {ECO:0007829|ProteomicsDB:D3Z2G1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 154..176 FT /note="Phosphodiesterase 4 upstream conserved regions FT (UCR)" FT /evidence="ECO:0000259|Pfam:PF18100" FT REGION 91..112 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 124..143 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 178 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000119312.2" SQ SEQUENCE 178 AA; 18714 MW; C56115993F47D066 CRC64; MRRSGTALSF LWTERVREPV DSGVAPVSPL GGGVILRRFS GTLLLPPLSS RLGSSGEAES AAHVVFTIGT QGTQRNLGSA QSSFDLENGL PGGKGLLDAQ SGPSLGRALQ PPVHHVQRRE SFLYRSDSDH EPSPKAVSRT SSAASDLHGE DMIVTPFAQV LASLRTVRNN VAALAHGP //