ID D3YZE6_MOUSE Unreviewed; 166 AA. AC D3YZE6; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 24-JUL-2024, entry version 85. DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059}; DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059}; DE Flags: Fragment; GN Name=Ugt1a6a {ECO:0000313|Ensembl:ENSMUSP00000115642.2}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115642.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000115642.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115642.2}; RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; CC Evidence={ECO:0000256|RuleBase:RU362059}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004389}. Membrane CC {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}; Single- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167, CC ECO:0000256|RuleBase:RU362059}. CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family. CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3YZE6; -. DR SMR; D3YZE6; -. DR jPOST; D3YZE6; -. DR PeptideAtlas; D3YZE6; -. DR ProteomicsDB; 361270; -. DR Ensembl; ENSMUST00000140092.8; ENSMUSP00000115642.2; ENSMUSG00000054545.18. DR MGI; MGI:2137698; Ugt1a6a. DR VEuPathDB; HostDB:ENSMUSG00000054545; -. DR GeneTree; ENSGT00940000163820; -. DR HOGENOM; CLU_097758_0_0_1; -. DR OMA; NRYRSFG; -. DR ChiTaRS; Ugt1a6a; mouse. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000054545; Expressed in urinary bladder and 87 other cell types or tissues. DR ExpressionAtlas; D3YZE6; baseline and differential. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC. DR CDD; cd03784; GT1_Gtf-like; 1. DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1. DR InterPro; IPR050271; UDP-glycosyltransferase. DR InterPro; IPR002213; UDP_glucos_trans. DR InterPro; IPR035595; UDP_glycos_trans_CS. DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1. DR PANTHER; PTHR48043:SF157; UDP GLUCURONOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A3 PRECURSOR-RELATED; 1. DR Pfam; PF00201; UDPGT; 1. DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1. DR PROSITE; PS00375; UDPGT; 1. PE 3: Inferred from homology; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022989}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT NON_TER 166 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115642.2" SQ SEQUENCE 166 AA; 18261 MW; BF18AFA26FCFD9DA CRC64; MPNMIFLGGI NCKKKGKLTQ EFEAYVNASG EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNK //