ID D3YZE6_MOUSE Unreviewed; 166 AA. AC D3YZE6; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 16-JAN-2019, entry version 62. DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059}; DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059}; DE Flags: Fragment; GN Name=Ugt1a6a {ECO:0000313|Ensembl:ENSMUSP00000115642}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115642, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115642, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115642, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000115642} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115642}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; CC Evidence={ECO:0000256|RuleBase:RU362059}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; CC Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}. CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family. CC {ECO:0000256|RuleBase:RU003718, ECO:0000256|SAAS:SAAS00846206}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC087780; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC087801; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; D3YZE6; -. DR jPOST; D3YZE6; -. DR MaxQB; D3YZE6; -. DR PeptideAtlas; D3YZE6; -. DR PRIDE; D3YZE6; -. DR Ensembl; ENSMUST00000140092; ENSMUSP00000115642; ENSMUSG00000054545. DR MGI; MGI:2137698; Ugt1a6a. DR eggNOG; KOG1192; Eukaryota. DR eggNOG; COG1819; LUCA. DR GeneTree; ENSGT00940000163820; -. DR HOGENOM; HOG000220831; -. DR OMA; WWIESSS; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000054545; Expressed in 60 organ(s), highest expression level in liver. DR ExpressionAtlas; D3YZE6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC. DR InterPro; IPR002213; UDP_glucos_trans. DR InterPro; IPR035595; UDP_glycos_trans_CS. DR Pfam; PF00201; UDPGT; 1. DR PROSITE; PS00375; UDPGT; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Glycosyltransferase {ECO:0000256|RuleBase:RU003718}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transferase {ECO:0000256|RuleBase:RU003718, KW ECO:0000256|SAAS:SAAS00846202}. FT DOMAIN 86 129 UDPGT. {ECO:0000259|PROSITE:PS00375}. FT COILED 145 165 {ECO:0000256|SAM:Coils}. FT NON_TER 166 166 {ECO:0000313|Ensembl:ENSMUSP00000115642}. SQ SEQUENCE 166 AA; 18261 MW; BF18AFA26FCFD9DA CRC64; MPNMIFLGGI NCKKKGKLTQ EFEAYVNASG EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNK //