ID D3YZ96_MOUSE Unreviewed; 207 AA. AC D3YZ96; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-MAR-2024, entry version 78. DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059}; DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059}; DE Flags: Fragment; GN Name=Ugt1a7c {ECO:0000313|Ensembl:ENSMUSP00000123452.2}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123452.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123452.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123452.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000123452.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123452.2}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; CC Evidence={ECO:0000256|RuleBase:RU362059}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004389}. Membrane CC {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}; Single- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167, CC ECO:0000256|RuleBase:RU362059}. CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family. CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3YZ96; -. DR SMR; D3YZ96; -. DR jPOST; D3YZ96; -. DR MaxQB; D3YZ96; -. DR PeptideAtlas; D3YZ96; -. DR ProteomicsDB; 310283; -. DR Ensembl; ENSMUST00000150634.8; ENSMUSP00000123452.2; ENSMUSG00000090124.8. DR MGI; MGI:3032636; Ugt1a7c. DR VEuPathDB; HostDB:ENSMUSG00000090124; -. DR GeneTree; ENSGT00940000163820; -. DR HOGENOM; CLU_1312689_0_0_1; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000090124; Expressed in proximal tubule and 56 other cell types or tissues. DR ExpressionAtlas; D3YZ96; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC. DR CDD; cd03784; GT1_Gtf-like; 1. DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1. DR InterPro; IPR002213; UDP_glucos_trans. DR InterPro; IPR035595; UDP_glycos_trans_CS. DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1. DR PANTHER; PTHR48043:SF157; UDP GLUCURONOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A3 PRECURSOR-RELATED; 1. DR Pfam; PF00201; UDPGT; 1. DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1. DR PROSITE; PS00375; UDPGT; 1. PE 3: Inferred from homology; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|RuleBase:RU362059}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..25 FT /evidence="ECO:0000256|RuleBase:RU362059" FT CHAIN 26..207 FT /note="UDP-glucuronosyltransferase" FT /evidence="ECO:0000256|RuleBase:RU362059" FT /id="PRO_5005126412" FT NON_TER 207 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000123452.2" SQ SEQUENCE 207 AA; 22562 MW; 7C459C3CD1AFC646 CRC64; MAPADFPASL PLCVCLLLAS GLAQAGRLLV VPMDGSHWFT MQTVVEKLLH KGHEVVVVVP EEFEAYVNAS GEHGIVVFSL GSMVSEIPEK KAMEIAEALG RIPQTVLWRY TGTRPSNLAK NTILVKWLPQ NDLLGHPKTR AFITHSGSHG IYEGICNGVP MVMMPLFGDQ MDNAKRMETR GAGVTLNVLE MTADDLENAL KTVINNK //