ID D3YZ96_MOUSE Unreviewed; 207 AA. AC D3YZ96; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 09-DEC-2015, entry version 36. DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059}; DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059}; DE Flags: Fragment; GN Name=Ugt1a7c {ECO:0000313|Ensembl:ENSMUSP00000123452, GN ECO:0000313|MGI:MGI:3032636}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123452, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123452, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123452, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000123452} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123452}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- CATALYTIC ACTIVITY: UDP-glucuronate + acceptor = UDP + acceptor CC beta-D-glucuronoside. {ECO:0000256|RuleBase:RU362059}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; CC Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}. CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family. CC {ECO:0000256|RuleBase:RU003718}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000123452}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC087780; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC087801; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10090.ENSMUSP00000072803; -. DR PaxDb; D3YZ96; -. DR PRIDE; D3YZ96; -. DR Ensembl; ENSMUST00000150634; ENSMUSP00000123452; ENSMUSG00000090124. DR MGI; MGI:3032636; Ugt1a7c. DR eggNOG; COG1819; LUCA. DR eggNOG; KOG1192; Eukaryota. DR GeneTree; ENSGT00760000118949; -. DR HOGENOM; HOG000220832; -. DR OrthoDB; EOG7GBFWS; -. DR NextBio; 35549739; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; D3YZ96; -. DR ExpressionAtlas; D3YZ96; baseline and differential. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central. DR GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central. DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central. DR GO; GO:0009813; P:flavonoid biosynthetic process; IBA:GO_Central. DR GO; GO:0052696; P:flavonoid glucuronidation; IBA:GO_Central. DR GO; GO:0052697; P:xenobiotic glucuronidation; IBA:GO_Central. DR InterPro; IPR002213; UDP_glucos_trans. DR PANTHER; PTHR11926; PTHR11926; 1. DR Pfam; PF00201; UDPGT; 1. DR PROSITE; PS00375; UDPGT; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Glycosyltransferase {ECO:0000256|RuleBase:RU003718}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|RuleBase:RU362059}; KW Transferase {ECO:0000256|RuleBase:RU003718}. FT SIGNAL 1 25 {ECO:0000256|RuleBase:RU362059}. FT CHAIN 26 207 UDP-glucuronosyltransferase. FT {ECO:0000256|RuleBase:RU362059}. FT /FTId=PRO_5005126412. FT COILED 186 206 {ECO:0000256|SAM:Coils}. FT NON_TER 207 207 {ECO:0000313|Ensembl:ENSMUSP00000123452}. SQ SEQUENCE 207 AA; 22562 MW; 7C459C3CD1AFC646 CRC64; MAPADFPASL PLCVCLLLAS GLAQAGRLLV VPMDGSHWFT MQTVVEKLLH KGHEVVVVVP EEFEAYVNAS GEHGIVVFSL GSMVSEIPEK KAMEIAEALG RIPQTVLWRY TGTRPSNLAK NTILVKWLPQ NDLLGHPKTR AFITHSGSHG IYEGICNGVP MVMMPLFGDQ MDNAKRMETR GAGVTLNVLE MTADDLENAL KTVINNK //